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Preparation method for ferrite nano-particles

A nanoparticle and ferrite technology, which is applied in the field of nanomaterial preparation and biomedical engineering applications, can solve the problems of poor dispersion and stability of nanoparticles, no successful method, size and shape changes, etc., and achieve good biophase Compatibility, improve biocompatibility, eliminate the effect of environmental pollution

Active Publication Date: 2013-03-27
郑州天兆医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the tedious solvent replacement process is necessary to transfer the nanoparticles in these organic solutions to the aqueous phase, which often leads to drastic changes in size and shape, and makes the dispersion and stability of the nanoparticles worse.
Up to now, there are basically no successful methods for preparing long-term (more than half a year) stable and uniformly dispersed aqueous ferrite (such as ferric oxide, cobalt iron oxide) nanoparticles, and it is also very difficult to synthesize them in large quantities.

Method used

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  • Preparation method for ferrite nano-particles

Examples

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preparation example Construction

[0021] The present invention proposes a method for preparing ferrite nanoparticles, which is prepared by chemical co-precipitation, such as figure 1 As shown, it specifically includes the following steps:

[0022] Step 1: Add 0.01 to 10.0 g of polymer dispersant, 0.25 to 25 mmol (preferably 2.5 mmol) of FeCl 3 ·6H 2 O and 0.125 to 25 mmol (preferably 1.25 mmol) of FeCl 2 4H 2 O (the FeCl 2 4H 2 O can be replaced by the same amount of cobalt salts, manganese salts, nickel salts, zinc salts, gadolinium salts, europium salts or neodymium salts) dissolved in 300mL ultrapure water to obtain iron-containing mixed salts dispersed by polymer dispersants solution.

[0023] The polymer dispersant comprises one or two kinds of polyvinylpyrrolidone PVP, polyvinyl alcohol (PVA), polyacrylamide (PAM) and polyethylene glycol (PEG), polyacrylic acid (PPA), lignin Sodium Sulfonate, Ammonium Lignin Carboxylate. When it is a mixture of two polymer dispersants, there is no specific requir...

Embodiment 1

[0033] A method for preparing ferrite nanoparticles proposed in this embodiment specifically includes the following steps:

[0034] Step 1: 10.0g of polyvinylpyrrolidone (Mw=2000), 0.68g of 2.5mmol of FeCl 3 ·6H 2 O and 0.25g 1.25mmol of FeCl 2 4H 2 O was dissolved in 300mL ultrapure water to obtain an iron-containing mixed salt solution dispersed in a polymer dispersant.

[0035] Step 2: Dilute 58mL of NH with a pH equal to 10 4 The OH solution was added dropwise to the iron-containing mixed salt solution under ultrasonic vibration and nitrogen bubbling within 30 minutes to obtain a black-brown nano-ferrite solution dispersed in a polymer dispersant.

[0036] Step 3: Add 200mL of sodium citrate aqueous solution containing 34mmol of sodium citrate dropwise to the dark brown nano-ferrite solution dispersed in the polymer dispersant under the condition of ultrasonic oscillation and nitrogen bubbling within 10min to obtain the polymer dispersant Nano-ferrite solution dispers...

Embodiment 2

[0041] A method for preparing ferrite nanoparticles proposed in this embodiment specifically includes the following steps:

[0042] Step 1: 0.01g of polyvinylpyrrolidone (molecular weight is 100000), 0.68g of 2.5mmol of FeCl 3 ·6H 2 O and 0.25 g FeCl 2 4H 2 O was dissolved in 300mL ultrapure water to obtain an iron-containing mixed salt solution dispersed in a polymer dispersant.

[0043] Step 2: Add 30 mL of NaOH solution with a pH value equal to 10 to the iron-containing mixed salt solution under ultrasonic vibration and nitrogen bubbling within 30 minutes to obtain a black-brown nano-iron oxide dispersed in a polymer dispersant mixed with an alkali solution body solution.

[0044] Step 3: Add 200mL of sodium citrate aqueous solution containing 1.7mmol of sodium citrate dropwise to the dark brown nano-ferrite solution dispersed in polymer dispersant under the conditions of ultrasonic vibration and nitrogen bubbling within 30min to obtain polymer dispersion agent and pol...

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Abstract

The invention provides a preparation method for ferrite nano-particles. The method comprises, in particular, step 1, preparing a iron-containing mixing salt solution dispersed by a high polymer dispersant; step 2, preparing a nano-ferrite solution dispersed by a high polymer dispersant and a polybasic acid salt; step 3, preparing a stable nano-ferrite solution dispersed through a multielement chelating agent-containing composite stabilizing agent; step 4, carrying out washing, centrifuging and separating. The ferrite nano-particles prepared through the preparation method provided by the present invention has good water stability, and can be stabilized in a water phase more than 6 months without generation of obvious deposition, and has excellent superparamagnetism and a coercive force less than 300 e.

Description

technical field [0001] The invention belongs to the technical field of nanomaterial preparation and biomedical engineering application, and specifically relates to a method for preparing ferrite nanoparticles dispersed in aqueous solution for a long period of time by using two or more multifunctional stabilizers. Background technique [0002] Over the past few decades, superparamagnetic nanoparticles (NPs) such as superparamagnetic iron oxide, ultrasmall superparamagnetic iron oxide, have been used as magnetic resonance (MR) T1 and T2 / T2 ＊ Spin-relaxing contrast agents (CAs). Various clinical and novel imaging applications based on these nanoparticles have been developed, including imaging of endothelial cells such as liver and spleen, magnetic resonance perfusion imaging of brain, brain tumors, heart and kidney, magnetic resonance angiography, tumor angiography , more precise tumor localization, thrombus imaging, lymph node metastasis, detection of magnetic probe-labeled c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/18A61K49/06C04B35/26C04B35/626
Inventor 宋玉军
Owner 郑州天兆医疗科技有限公司
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