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Photocatalytic oxidation process for preparing multi-aldehyde sodium alginate

A polyaldehyde-based sodium alginate, photocatalytic oxidation technology, applied in the direction of chemical recovery, can solve the problems of strong hydrophilicity, low drug encapsulation rate, high price of sodium periodate, etc., to reduce production costs and be operable Strong, reasonable process effect

Inactive Publication Date: 2013-01-09
高健
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the use of sodium alginate in medical materials and pharmaceutical excipients has its obvious shortcomings: for example, under physiological conditions, the gel matrix formed by it is unstable due to the exchange of divalent cations with monovalent cations in the in vivo environment. Mechanical properties; the formed gel lacks the ability to recognize specific cells, has strong hydrophilicity, large gel pore size, fast release rate and is prone to burst release, especially when wrapping water-soluble small molecule drugs, leakage often occurs , resulting in low drug encapsulation efficiency and short release time; in addition, the degradation rate of sodium alginate in the body is very low
Partial oxidation of sodium alginate can be achieved by sodium periodate, but this method is not easy to control the degree of oxidation, and sodium periodate is expensive and consumes a lot, so it is not suitable for popularization and application
Another oxidation method reported in the literature uses metal oxyacids such as potassium permanganate as an oxidant to partially oxidize sodium alginate, but the degree of oxidation of the oxidized product is difficult to control, and the selectivity of the product is low, and it is easy to over-oxidize to carboxylic acid

Method used

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  • Photocatalytic oxidation process for preparing multi-aldehyde sodium alginate

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Effect test

Embodiment 1

[0017] Embodiment 1, with reference to figure 1 , a kind of photocatalytic oxidation method prepares polyaldehyde sodium alginate, and its steps are as follows:

[0018] (1) Soak the activated carbon in an acid solution with a mass concentration of 3% for 20 minutes, then fully wash it with deionized water, and dry it at 100°C to obtain activated carbon; take butyl titanate, add isopropanol and Nitric acid, stirred at room temperature, and activated activated carbon was added to it, then slowly added distilled water, the volume ratio of nitric acid, butyl titanate, isopropanol to distilled water was 1:6:20:0.5, and continued to stir to obtain black Sol; the black sol is ultrasonically oscillated, the ultrasonic power is 10-KHZ, and the sound intensity is 0.5W / cm 2 , dried after ultrasonication, ground to 0.2mm, and calcined at 400°C to obtain activated carbon-supported TiO 2 Catalyst; Described acidic solution is hydrochloric acid solution;

[0019] (2) Add sodium alginate ...

Embodiment 2

[0021] Embodiment 2, with reference to figure 1 , a kind of photocatalytic oxidation method prepares polyaldehyde sodium alginate, and its steps are as follows:

[0022] (1) Soak the activated carbon in an acidic solution with a mass concentration of 30% for 120 minutes, then fully wash it with deionized water, and dry it at 150°C to obtain activated carbon; take butyl titanate, add isopropanol and Nitric acid, stirred at room temperature, and activated activated carbon was added to it, then slowly added distilled water, the volume ratio of nitric acid, butyl titanate, isopropanol to distilled water was 1: 7: 30: 2.0, and continued to stir to obtain black Sol; ultrasonically oscillate the black sol, the ultrasonic power is 40KHZ, and the sound intensity is 2.0W / cm 2 , dried after ultrasonication, ground to 2.0mm, and calcined at 500°C to obtain activated carbon-supported TiO 2 Catalyst; Described acidic solution is sulfuric acid solution;

[0023] (2) Add sodium alginate to...

Embodiment 3

[0025] Embodiment 3, with reference to figure 1 , a kind of photocatalytic oxidation method prepares polyaldehyde sodium alginate, and its steps are as follows:

[0026] (1) Soak the activated carbon in an acidic solution with a mass concentration of 15% for 60 minutes, then fully wash with deionized water, and dry at 120°C to obtain activated activated carbon; take butyl titanate, add isopropanol and Nitric acid, stirred at room temperature, and activated activated carbon was added to it, then slowly added distilled water, the volume ratio of nitric acid, butyl titanate, isopropanol to distilled water was 1:6.5:25:1.0, and continued to stir to obtain black Sol; ultrasonically oscillate the black sol, the ultrasonic power is 30KHZ, and the sound intensity is 1.0W / cm 2 , dried after ultrasonication, ground to 1.0 mm, and calcined at 450 ° C to obtain activated carbon-supported TiO 2 Catalyst; Described acid solution is HF acid solution;

[0027] (2) Add sodium alginate to th...

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Abstract

The invention discloses a photocatalytic oxidation process for preparing multi-aldehyde sodium alginate, which is characterized by comprising the following steps of: preparing an active carbon-supported TiO2 catalyst by using a sol-gel method; adding the catalyst into the prepared solution of sodium alginate, ensuring that adsorption balance is reached under the dark-state condition, introducing air or oxygen at a certain flow rate, turning on an ultraviolet lamp, performing clock reaction, filtering after the reaction is finished, adding a proper amount of sodium chloride into the filtrate, fully dissolving the sodium chloride, adding excessive ethanol to separate out a product, and performing suction filtration and drying to obtain an initial product; and performing dialysis and freeze-drying to obtain the multi-aldehyde sodium alginate product. In the process, an expensive oxidant of sodium periodate is avoided, so the production cost is reduced and the pollution is lightened. The process is more reasonable and high in operability, and is a feasible green method for preparing the multi-aldehyde sodium alginate.

Description

technical field [0001] The invention relates to a preparation method of sodium alginate, in particular to a photocatalytic oxidation method for preparing polyaldehyde sodium alginate. Background technique [0002] Sodium alginate is a sodium salt of a polyanionic polysaccharide carbohydrate (alginic acid) extracted from natural brown algae, which is composed of β-D-mannuronic acid (M sugar) and α-L-guluronic acid ( G sugar) composed of a linear block copolymer, non-toxic, good physiological compatibility, can be slowly degraded into mannose and gulose in the body and then excreted with urine, widely used in pharmaceutical preparations, tissue engineering, cell culture and other fields. However, the use of sodium alginate in medical materials and pharmaceutical excipients has its obvious shortcomings: for example, under physiological conditions, the gel matrix formed by it is unstable due to the exchange of divalent cations with monovalent cations in the in vivo environment....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/04
CPCY02P20/584
Inventor 高健许同桃
Owner 高健