Dialysis membrane material having physiological function and preparation method thereof

Abstract

The invention discloses a dialysis membrane material having a physiological function and a preparation method for the same. According to the invention, a TiO2 nanotube array film permeable at two ends is used as a substrate, and renal tubular epithelial cells and umbilical vein endothelial cells are mixedly planted on the film so as to endow the film with a physiology function. The TiO2 nanotube array film is applied in dialysis membrane materials for the first time; since the TiO2 nanotube array film has good blood compatibility, photocatalysis, hydrophilicity and self-cleaning capability, disadvantages of conventional polysulfone membranes are overcome, and requirements for membrane materials for hemodialyzers are well met. The dialysis membrane material having the physiological function prepared by the method can fulfill the functions of kidney tubules and glomerulus, enables an apparatus to be simplified and is favorable for construction of miniaturized biological artificial kidneys. The material is widely used in biomedical fields, e.g., separation of proteins, bioactive filtration, diffusion of high-molecular weight substances, filtration of molecules, conveying of drugs, etc.

Description

technical field [0001] The invention belongs to biomaterial technology, and specifically relates to a dialysis membrane material with physiological functions, which is a TiO material with excellent biocompatibility, high porosity and permeability at both ends. 2 nanotube array film. Background technique [0002] Kidney disease has become another major disease that threatens human health. According to the announcement of the International Society of Nephrology, more than 500 million people in the world suffer from different forms of kidney diseases, and more than 1 million people die of related cardiovascular and cerebrovascular diseases every year. It is roughly estimated that the cumulative population of chronic kidney disease in my country is about 100 million. It is true that how to prevent and treat chronic kidney disease is a very important issue, but how to improve the technical level of renal replacement therapy after patients with uremia is a huge challenge we are ...

AI Technical Summary

Problems solved by technology

Cellulose is the earliest used hemodialysis membrane material, its wet strength and urea permeability can meet the basic clinical requirements, but its hemocompatibility is poor; polymer materials such as polysulfone are due to their membrane pore size and pore size The distribution can be easily controlled by changing the composition of the casting fluid, and it can effectively remove toxic substances with medium molecular weight in the blood, so it is currently the most widely used material in hemodialyzers

However, this type of material is a strongly hydrophobic material, and it needs to be hydrophilized before being used as a dialysis membrane. At the same time, these membrane materials also have the following problems: they are sensitive to sterilization technology, and the current sterilization technology It is easy to change the quality of the membrane; the pore size distribution of the membrane is wide and microscopically inhomogeneous, so that while filtering out toxins in the blood, it also filters useful protein molecules; it is easy to cause various protein molecules and biomolecules to adsorb on the membrane biofouling; contamination by polymers

First of all, the whole process requires hemofiltration device and RAD to form a complex series circuit, so the structure is more complex, which is not conducive to the "miniaturization" of bioartificial kidneys and in vivo transplantation

Second, today's RAD circuits require multiple peristaltic pumps to provide extracorporeal driving pressure to compensate for the lack of flow rate, which severely limits the miniaturization of the device and the realization of the goal of portability and in vivo implantability.

Finally, today's RAD does not have anticoagulant function, and heparin must be given continuously for anticoagulation before the blood enters the RAD

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