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Method for preparing magnetic hollow cluster from ferroferric oxide nano crystals by one step

A ferroferric oxide and magnetic technology, applied in the field of material chemistry, can solve the problems of large effective dosage and low relaxation rate, and achieve the effects of enlarged reaction scale, controllable experimental conditions, and controllable morphology

Inactive Publication Date: 2012-03-14
SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the imaging effect of the existing superparamagnetic iron oxide nanoparticles used as a developer needs to be further optimized, and the relaxation rate is not high, and the effective dosage is relatively large, which cannot meet the needs of practical applications.

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  • Method for preparing magnetic hollow cluster from ferroferric oxide nano crystals by one step
  • Method for preparing magnetic hollow cluster from ferroferric oxide nano crystals by one step
  • Method for preparing magnetic hollow cluster from ferroferric oxide nano crystals by one step

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preparation example Construction

[0029] More specifically, the preparation method includes the following steps: firstly prepare oleic acid-protected iron ferric oxide particles with a diameter of 2-10 nm by hydrothermal method, redisperse them in a certain amount of chloroform after ethanol centrifugal washing; Ferric oxide particles were added to the three-liquid phase system, and then reacted at room temperature after adding the surface modifier after shaking; the reaction product was adsorbed to the wall by a magnet, and washed several times with a large amount of ethanol; finally, it was dispersed in water to obtain A cluster structure of Fe3O4 stably dispersed in polar solvents.

[0030] Further, the optimization scheme of the above-mentioned technical solution may also include:

[0031] (1) The starting material of this reaction is oil-soluble magnetic particles, which can be extended to other magnetic materials such as manganese dioxide, doped magnetic particles, or even other non-magnetic nanoparticle...

Embodiment 1

[0039] A certain amount of ferric oxide (2.5 mg / mL dispersed in 5 mL chloroform) was used as a raw material, dispersed in a three-phase microemulsion system formed by 5 mL water and 25 mL ethanol, sealed and shaken in a 50 mL test tube After shaking for 15 minutes, add dopamine (0.04 g) and continue to shake for 360 minutes at room temperature; after the reaction, add 45-50 mL of ethanol, use an external magnetic field to absorb and wash, and finally disperse in 20 mL of water.

[0040] The transmission electron micrographs of the product show that the prepared magnetic hollow clusters are composed of many small-sized Fe3O4 particles, which are well dispersed. The particle size is between 55-70 nm and the wall thickness is between 15-35 nm.

Embodiment 2

[0042] A certain amount of ferric oxide (5 mg / mL dispersed in 5 mL cyclohexane) was used as a raw material, dispersed in a three-phase microemulsion system formed by 10 mL water and 20 mL methanol, and sealed in a 50 mL test tube After shaking for 15 minutes, add sodium dodecylsulfonate (0.06 g), and continue to shake and react at room temperature for 360 minutes; in 20 mL of water.

[0043] The transmission electron micrograph of the product shows that the prepared magnetic solid cluster is composed of many small-sized ferric oxide particles, which are well dispersed, and the particle size is about 65±25 nm.

[0044] From the above two examples, it can be concluded that the cluster structure can not only have a hollow core, but also its wall thickness is adjustable (the greater the concentration of ferroferric oxide, the thicker the wall thickness of the hollow cluster structure) and its size is uniform The distribution is around 65±25 nm; observed by high-resolution transmi...

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Abstract

The invention discloses a method for preparing a magnetic hollow cluster from ferroferric oxide nano crystals by one step. The method comprises the step of uniformly mixing oil soluble ferroferric oxide nano particles and a surface modifier with an active functional group at room temperature and ensuring the oil soluble ferroferric oxide nano particles and the surface modifier to be reacted in a micro emulsion system consisting of three liquid phases to form the hydrophilic magnetic hollow cluster consisting of a plurality of ferroferric oxide particles. The three liquid phase system is formed in a mode that water, a nonpolar organic solvent and a polar organic solvent are mixed. In the preparation method disclosed by the invention, the reaction is carried out at room temperature. The preparation method is simple to operate. Used medicines are simple and easy to obtain. The preparation method has good repetitiveness. The adverse effects of fussiness and high temperature in the conventional process of preparing the cluster are eliminated. The prepared nano cluster has high relaxation rate and low biotoxicity. Moreover, the surface of the prepared nano cluster is provided with the functional group so as to provide the necessary preparation for the actual application of the nano cluster to the fields of a biomarker, tissue and living imaging, clinical diagnosis and the like.

Description

technical field [0001] The invention relates to a preparation method of nanomaterials, in particular to a method for preparing magnetic hollow clusters from iron ferric oxide nanocrystals in one step, and belongs to the technical field of material chemistry. Background technique [0002] With the development of molecular biology, medical diagnostics and other disciplines and the application of various biomarkers and detection techniques, superparamagnetic iron oxide nanoparticles have received extensive attention. This is because it has good biocompatibility, has the functions of magnetic storage and separation, controlled release of drugs, and magnetic resonance imaging contrast agent. Among them, magnetic resonance imaging technology has shown great potential in the field of medical diagnosis. Compared with other imaging techniques, MRI technology has unique advantages, such as non-tissue invasion, high-resolution imaging of soft tissue to achieve deep tissue imaging, etc...

Claims

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Application Information

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IPC IPC(8): C01G49/08B82Y30/00B82Y40/00
Inventor 王强斌李轮
Owner SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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