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Surface-controlled and polymerization-modification biological material and preparation method thereof

A technology of biomaterials and surface grafting, which is applied in the field of biomaterials modified by surface controllable polymerization and its preparation, can solve the problems of low grafting rate, high cost of ligands, toxicity, etc., and achieve simplified reaction conditions and excellent reaction effects Visible, readily available raw materials

Active Publication Date: 2013-06-19
南京周宁琳新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, in the conventional RATRP reaction, 2,2'bipyridine (bpy) is generally used as the ligand, which has problems such as high cost and toxicity of the ligand.
In addition, no matter it is RATRP method or ATRP method, when it is used for graft polymerization on the surface of materials, there is a problem of low grafting rate, which leads to the unsatisfactory anticoagulant performance of the surface of biomaterials.
Furthermore, the biomaterials prepared by the conventional RATRP reaction have no antibacterial function.

Method used

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  • Surface-controlled and polymerization-modification biological material and preparation method thereof
  • Surface-controlled and polymerization-modification biological material and preparation method thereof
  • Surface-controlled and polymerization-modification biological material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Add 1% (wt%) LaCl to 10 silicone rubber diaphragms 3 -In ethanol aqueous solution, magnetically stirred for 6h, and vacuum dried at 110°C for 24h after taking out to obtain LaCl 3 ·6H 2 O-treated silicone rubber diaphragm. LaCl 3 ·6H 2 The O-treated silicone rubber diaphragm and 15 mL of secondary water were put into a three-necked flask, and 0.15 mL of chloromethyltriethoxysilane was added, stirred at room temperature for 10 min, and then 0.02 mL of benzoyl peroxide was added. The film that the surface has fixed the benzoyl peroxide initiator is put into the aqueous solution of 1mol / L ammonium phosphate zwitterion (R is methacrylate type), and adds CuCl 2 , the ratio of the amount of substance is: M 两性离子 :M 卤化铜 =120:7, and then nitrogen protection. The reaction was stirred at room temperature for 72h. Take out the diaphragm, wash it with water and dry it under vacuum.

Embodiment 2

[0053] Add 0.1% (wt%) LaCl to 10 silicon rubber diaphragms 3 -in ethanol aqueous solution, magnetically stirred for 1h, and vacuum dried at 110°C for 24h after taking out to obtain LaCl 3 ·6H 2 O-treated silicone rubber diaphragm. LaCl 3 ·6H 2 The O-treated polymer film and 5 mL of secondary water were put into a three-neck flask, and 0.05 mL of chloromethyltrimethoxysilane was added. After stirring for 5 min at room temperature, 0.002 mL of tert-butyl hydrogen peroxide was added. The film that the surface has fixed tert-butyl peroxide hydrogen initiator is put into the aqueous solution of 0.1mol / L ammonium phosphate zwitterion (R is methacrylate type), and adds CuBr 2 , the ratio of the amount of substance is: M 两性离子 :M CuBr2 =90:1, then nitrogen protection. The reaction was stirred at room temperature for 1 h. Take out the diaphragm, wash it with water and dry it under vacuum.

Embodiment 3

[0055] Add 0.2% (wt%) LaCl to 10 polyurethane diaphragms 3 - In aqueous ethanol solution, magnetically stirred for 2 hours, and then vacuum dried at 110°C for 24 hours to obtain LaCl 3 ·6H 2 O-treated polyurethane diaphragm. LaCl 3 ·6H 2 The O-treated polymer film and 6 mL of secondary water were put into a three-necked flask, and 0.05 mL of dichloromethyltrimethoxysilane was added. After stirring for 6 min at room temperature, 0.003 mL of tert-butyl hydrogen peroxide was added. The film that the surface has fixed tert-butyl peroxide hydrogen initiator is put into the aqueous solution of 0.2mol / L sulfonamide zwitterion (R is methacrylate type), and adds CuBr 2 , the ratio of the amount of substance is: M 两性离子 :M CuBr2 =95:2, then nitrogen protection. The reaction was stirred at room temperature for 6h. Take out the diaphragm, wash it with water and dry it under vacuum.

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Abstract

The invention relates to a surface-controlled and polymerization-modification biological material. The biological material is characterized in that a base body is treated by trivalent lanthanum ion / silanization, and the surface of the biological material is grafted with a brush-shaped zwitter-ion polymer layer. Generally, an ATRP (atom transfer radical polymerization) method or an RATRP (reverse atom transfer radical polymerization) method is adopted to use 2, 2'-bipyridyl (Bpy) as ligand, and the prepared grafting materials have the problems of low grafting rate. The surface-controlled and polymerization-modification biological material adopts a special complexing and catalyzing system formed by coordination of free trivalent lanthanum ions / silane coupling agent and copper halide to realize controllable polymerization of the activity of zwitter ions. In the surface-controlled and polymerization-modification biological material, the specificity and the functionality of attachment protein on the surface of the biological material can be effectively adjusted and controlled, the adhesion of blood cells and the multi-path activation of blood can be inhibited, simultaneously, the bacterial adhesion is reduced, and the surface of the biological material with excellent blood compatibility is obtained. The invention also discloses a preparation method of the surface-controlled and polymerization-modification biological material.

Description

technical field [0001] The present invention relates to a biological material and a preparation method thereof, in particular to a biological material modified by surface controllable polymerization and a preparation method thereof, using a new RATRP catalytic system, that is, using free trivalent lanthanum ion / silane coupling agent and A special complex catalytic system formed by copper halide coordination participates in the RATRP reaction, grafting zwitterionic monomers to the surface of biomaterials, realizing the "active" controllable polymerization of zwitterions, and finally obtaining Density, biomaterial with excellent hemocompatibility and antibacterial function. Background technique [0002] Biopolymer materials are materials that combine with biological systems to diagnose, treat or replace tissues and organs in the body or enhance their functions. They are divided into natural polymer materials and synthetic polymer materials. Biopolymer materials are widely use...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J7/16C08J7/12C08L83/04C08L75/04C08L23/06C08L27/06C08L27/18A61L33/06
Inventor 周宁琳陆春燕沈健汤毅达金素星章峻
Owner 南京周宁琳新材料科技有限公司
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