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Method for treating addition wastewater in production process of lipoic acid

The technology of a production process and a treatment method is applied in the field of treatment of waste water in the addition process in the production process of lipoic acid, and achieves the effects of reducing waste water discharge, high treatment process efficiency and clear tasks.

Active Publication Date: 2013-05-01
JIANGSU TOHOPE PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0009] The purpose of the present invention is to provide a treatment method for the addition wastewater in the production process of lipoic acid, which comprehensively treats and utilizes the process wastewater generated in the addition process in the production process of lipoic acid, so that the inorganic aluminum salts and organic intermediates in the wastewater The body is fully recovered to solve the problem of treatment and recycling of wastewater in the addition process of lipoic acid manufacturers, and at the same time, the by-product ammonium alum products are widely used and have a large market demand

Method used

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Experimental program
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Effect test

Embodiment 1

[0028] The method for the comprehensive treatment and resource utilization of the addition waste water in the lipoic acid production process comprises the following steps:

[0029] (1) Add ammonium sulfate and sodium sulfate to the wastewater in the lipoic acid production and addition process. The amount of ammonium sulfate and sodium sulfate added is such that the Al in the wastewater 3+ : NH 4 + : SO 4 2- The molar ratio is 1.0 : 1.0 : 2.0, stirred at room temperature (20°C~25°C) to dissolve and react. Cool and crystallize naturally, and filter to obtain crude ammonium alum as a filter cake.

[0030] (2) Throw the crude ammonium alum into water, heat it to dissolve it, and prepare a saturated solution with a mass concentration of 49%, then cool it to room temperature to allow it to crystallize, filter, and dry the filter cake at 60°C for 8 hours to obtain ammonium alum The finished product has an ammonium alum content of 99.1%.

[0031] (3) Send the filtrate obtained...

Embodiment 2

[0034] The method for the comprehensive treatment and resource utilization of the addition waste water in the lipoic acid production process comprises the following steps:

[0035] (1) Add ammonium sulfate and sodium sulfate to the wastewater in the lipoic acid production and addition process. The amount of ammonium sulfate and sodium sulfate added is such that the Al in the wastewater 3+ :NH 4 + :SO 4 2- The molar ratio is 1 : 1.5 : 3.0, stirred at room temperature (20°C~25°C) to dissolve and react. Natural cooling and crystallization, filtering to obtain the thick ammonium alum of the filter cake;

[0036] (2) Throw the crude ammonium alum into water, heat it to dissolve it, and prepare a saturated solution with a mass concentration of 51%, then cool to room temperature to allow it to crystallize, filter, and dry the filter cake at 70°C for 7 hours to obtain ammonium alum The finished product has an ammonium alum content of 99.0%.

[0037] (3) Send the filtrate obtained ...

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Abstract

The invention discloses a method for treating addition wastewater in the production process of lipoic acid, which includes the following steps: adding a certain amount of ammonium sulfate and sodium sulfate into the lipoic acid addition wastewater, performing the reaction to generate aluminium ammonium sulfate, and carrying out crystallization, filtration and recrystallization to obtain the finished product of aluminium ammonium sulfate; and dividing filtrate into concentrated solution and permeate by nanofiltration, extracting adipic acid monoethyl ester and 8-chlorine-6-carbonyl ethyl caprylate from the concentrated solution by dichloroethane and toluene, carrying out reverse osmosis desalination on the extracted concentrated solution and the permeate and then carrying out biochemical treatment to discharge with standard level, wherein CODcr (Chemical Oxygen Demand) is less than or equal to 1,000. According to the invention, a reaction crystallization / nanofiltration / reverse osmosis coupling technology is adopted to carry out comprehensive treatment and resource utilization on the addition wastewater, the treatment process and an original production process are circulated into one whole body, and the treatment efficiency is high; the method can be used for effectively recovering aluminium salt and organic intermediates in the addition wastewater; a byproduct, i.e. aluminium ammonium sulfate with content higher than or equal to 99.0 percent, is obtained, and the method has the advantage on the aspect of production cost.

Description

technical field [0001] The invention relates to the technical field of waste water treatment in pharmaceutical factories, in particular to a treatment method for waste water in an addition process in the production process of lipoic acid. Background technique [0002] Alpha lipoic acid belongs to the B vitamins, and has preventive and therapeutic effects on various diseases related to active oxygen free radicals, such as diabetes, local ischemia-reperfusion injury, heavy metal poisoning, radiation damage, impulsive neuropathy and AIDS infection. [0003] Lipoic acid is synthesized from adipic acid as the starting material. The production process includes esterification, acyl chloride, addition, reduction, chlorination, cyclization, hydrolysis and acidification. Among them, the addition process uses aluminum trichloride as a catalyst to prepare 8-chloro-6-carbonyl octanoic acid ethyl ester from the addition reaction of 6-chloro-6-oxohexanoic acid ethyl ester and ethylene, and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C02F9/14C01F7/76C07C67/48C07C69/716C07C69/44C02F1/26C02F1/44C02F103/36
CPCY02A20/131
Inventor 王车礼邹振荣黄燕华宋国强姚致远陈建平钱振青陆惠刚
Owner JIANGSU TOHOPE PHARMA
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