Magnet composite drug-carrying microspheres and preparation method thereof
A technology of drug-loaded microspheres and microspheres, which can be used in pharmaceutical formulations, medical preparations with non-active ingredients, and non-active components of polymer compounds, which can solve the problems of difficult multifunctional modification, few functional groups, and poor hydrophilicity. , to achieve the effect of strong penetrating biofilm barrier function, simple preparation process and good stability
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Embodiment 1
[0029] Preparation process of composite drug-loaded microspheres. The drug used is a water-soluble drug doxorubicin, and the magnetic nanoparticles used are ferric oxide nanoparticles with a particle diameter of 7 nanometers and a saturation magnetization of 64.2 emu / g. The mass proportioning of raw materials is as follows:
[0030] PLGA:PVA=1:1.5;
[0031] PLGA: doxorubicin: magnetic nanoparticles = 100:10:3;
[0032] TAT-OQLCS:Chol=3:1;
[0033] Polymer lipid film: PLGA drug-loaded microspheres = 2.5:1.
[0034] (1) Weigh 5 mg of doxorubicin and dissolve it in 1 mL of distilled water, and set aside; weigh 50 mg of PLGA and place it in a small beaker, add 3 mL of dichloromethane to dissolve it completely, add 1.5 mg of magnetic nanoparticles, and use an ultrasonic cell pulverizer to Ultrasound was performed at 200W power. Add adriamycin aqueous solution to the small beaker during ultrasonication, and continue ultrasonication until a uniform water-in-oil emulsion is forme...
Embodiment 2
[0041] Preparation process of composite drug-loaded microspheres. The medicine used is bovine serum albumin, a water-soluble protein model medicine, and the magnetic nanoparticles used are iron ferric oxide nanoparticles with a particle diameter of 6 nanometers and a saturation magnetization of 73.7emu / g. The mass proportioning of raw materials is as follows:
[0042] PLGA:PVA=1:2;
[0043] PLGA: bovine serum albumin: magnetic nanoparticles = 60:5:5;
[0044] TAT-OQLCS:Chol=2:1;
[0045] Polymer lipid film: PLGA drug-loaded microspheres = 1:1.
[0046] (1) Weigh 5 mg of bovine serum albumin and dissolve it in 1 mL of distilled water for use; weigh 60 mg of PLGA and place it in a small beaker, add 3 mL of dichloromethane to dissolve it completely, add 5 mg of magnetic nanoparticles, and use an ultrasonic cell pulverizer at 50W Ultrasound at high power. Add bovine serum albumin aqueous solution to the small beaker during the ultrasonication process, and continue ultrasonica...
Embodiment 3
[0053] Preparation process of composite drug-loaded microspheres. The drug used is paclitaxel, an oil-soluble drug, and the magnetic nanoparticles used are iron ferric oxide nanoparticles with a particle diameter of 10 nm and a saturation magnetization of 79.3 emu / g. The mass proportioning of raw materials is as follows:
[0054] PLGA:PVA=1:1;
[0055] PLGA: paclitaxel: magnetic nanoparticles = 30:8:2;
[0056] TAT-OQLCS:Chol=4:1;
[0057] Polymer lipid film: PLGA drug-loaded microspheres = 4:1.
[0058] (1) Weigh 30mg of PLGA and place it in a small beaker, add 3mL of dichloromethane to dissolve it completely, add 2mg of magnetic nanoparticles and 8mg of paclitaxel, so that the magnetic nanoparticles are evenly dispersed, and the paclitaxel is completely dissolved;
[0059] (2) Pour the solution in the small beaker into a beaker filled with 10 mL of PVA solution with a concentration of 3 mg / mL, and use an ultrasonic cell pulverizer to perform ultrasound at a power of 100 ...
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