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Composite antimicrobial of nanometer silver bromide polymer and preparation method thereof

A compound antibacterial agent and polymer technology, which is applied in the field of functional polymer materials, can solve the problems of changing the permeability of bacterial cell membranes, not lasting antibacterial effect, and accelerating the death of bacteria, achieving uniform size, long antibacterial time, and environmental pollution. small effect

Active Publication Date: 2012-09-26
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, studies have shown (Sondi, I.; Salopek-Sondi, B.J. Colloid Interface Sci. 2004, 275, 177-182) that silver ions also have a damaging effect on bacterial cell membranes, changing the permeability of bacterial cell membranes, thereby accelerating bacterial cell membrane penetration. die
However, a single silver-based antibacterial agent has the disadvantages of volatile loss, insufficient antibacterial effect and easy discoloration.

Method used

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  • Composite antimicrobial of nanometer silver bromide polymer and preparation method thereof
  • Composite antimicrobial of nanometer silver bromide polymer and preparation method thereof
  • Composite antimicrobial of nanometer silver bromide polymer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] 1. Preparation of copolymer matrix

[0036]

[0037] Put monomer A1 (0.01mol) and monomer B1 (3.37g, 0.03mol) into THF (50mL) according to the amount ratio of the substances of 1:3, nitrogen gas for 30min, and dissolve the initiator AIBN (2.0wt%) in A small amount of THF was slowly added dropwise into the above solution with stirring. The reaction temperature was controlled at 55°C, and the polymerization reaction was carried out under nitrogen for 24 hours. After the reaction was completed, a sufficient amount of ether was added to the mixture, and a pale yellow solid precipitated out, which was washed several times with ether. In order to remove unreacted monomer, the product was extracted with acetone for 4h. Vacuum-dried at room temperature for 12 hours, and placed in a desiccator for later use.

[0038] 2. Doped silver bromide nanoparticles

[0039]

[0040]Dissolve 2.0 g of the above-mentioned copolymer matrix in 50 mL of nitromethane, and add 10 mL of a ...

Embodiment 2

[0042] The operating steps are the same as in Example 1. Wherein compound monomer B1 is replaced by monomer B2, and its structure is as follows:

[0043]

[0044] resolve resolution:

[0045]

[0046] In a 250mL three-necked flask, add 1-(3-aminopropyl) imidazole (6.38g, 0.05mol), triethylamine (10.12g, 0.10mol), CH 2 Cl 2 100 mL, under the condition of ice-water bath, nitrogen gas was passed for 30 min, and acryloyl chloride (9.05 g, 0.10 mol) was dropped into the reaction liquid. After the dropwise addition, the reaction was stirred at room temperature for 4 h. After the reaction is completed, use an appropriate amount of saturated NaHCO 3 The aqueous solution was washed until no bubbles were generated, the solvent was removed by rotary evaporation, and column chromatography (methanol:ethyl acetate=1:10) separated to obtain a colorless liquid with a yield of about 78%.

Embodiment 3

[0048] The operating steps are the same as in Example 1. Wherein compound monomer B1 is replaced by monomer B3, and its structure is as follows:

[0049]

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PUM

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Abstract

The invention provides a composite antimicrobial of a nanometer silver bromide polymer and a preparation method thereof and belongs to a functional polymer material technology field. First, a quaternary ammonium salt type macromolecule polymer is prepared by free radical polymerization. Organic / inorganic composite materials required by preparation of silver bromide nanoparticles are intermingled with the macromolecule polymer of quaternary ammonium salt by in situ precipitation. The composite antimicrobial in the invention has the advantages of a quaternary ammonium salt type organic antimicrobial and an Ag-type inorganic antimicrobial combined: low toxicity, wide antimicrobial spectrum and strong antimicrobial activity. Furthermore, the prepared silver bromide nanoparticles are not easy to to agglomerate and leak and antimicrobial time is long because of a stabilization effect of the macromolecule copolymers and complex anions. The method reduces the amount of Ag and overcomes the defects that a single Ag-type antimicrobial is easy to change colors by intermingling a little Ag with organic polymer materials besides. The composite antimicrobial can be added in an undertint base to prepare antimicrobial functional materials.

Description

technical field [0001] The invention discloses a composite antibacterial agent and a preparation method thereof, belonging to the technical field of functional polymer materials. It specifically relates to an organic / inorganic composite antibacterial agent in which silver bromide nanoparticles are doped in a quaternary ammonium salt polymer by an in-situ precipitation method and a preparation method thereof. Background technique [0002] If you use a microscope to observe the environment in which human beings live, you will find that there are countless harmful viruses and bacteria distributed in the space where people move. In recent years, various highly harmful infectious diseases such as SARS, bird flu, children's susceptible hand, foot and mouth disease, and the large-scale outbreak of influenza A (H1N1) worldwide have followed one after another. These highly fatal infectious diseases rely on The growth and spread of germs seriously threaten human life and health; in a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L33/14C08L33/24C08L39/04C08K3/16C08F220/34C08F220/60C08F226/06A01N59/16A01P1/00
Inventor 韩克飞汪海迪汪中明朱红
Owner BEIJING UNIV OF CHEM TECH
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