Composite nano-carrier capable of loading nucleic acid drugs efficiently and preparation method of composite nano-carrier
A nano-carrier and nucleic acid technology, which is applied in the direction of medical preparations of non-active ingredients, pharmaceutical formulas, non-effective ingredients of polymer compounds, etc., can solve the problems of inability to reach the target site, increased thrombus formation, low loading efficiency, etc., to achieve guaranteed In vivo compatibility, easy removal, low cost effect
Active Publication Date: 2013-01-09
ARMY MEDICAL UNIV
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The invention relates to a composite nano-carrier capable of loading nucleic acid drugs efficiently and a preparation method of the composite nano-carrier. The composite nano-carrier is composed of a degradable organic material and polyamine with different molecular weights, wherein the mass ratio of the polyamine with different molecular weights to the degradable organic material is (0.005: 100)-(3:7), the composite nano-carrier is spherical, the particle size of the composite nano-carrier ranges from 80 nm to 950 nm, and the nucleic acid drugs are distributed in the composite nano-carrier uniformly. The preparation method of the composite nano-carrier includes steps of firstly, dissolving the nucleic acid drugs into water to obtain internal water phase, dissolving the degradable organic material and the polyamine with different molecular weights into organic solvent to obtain organic phase, taking polyving alcohol aqueous solution as external water phase; secondly, emulsifying the internal water phase into the organic phase under ultrasonic action of a probe so as to form water-in-oil colostrum, emulsifying the water-in-oil colostrum into the external water phase under ultrasonic action of the probe so as to obtain oil-in-water multiple emulsion, stirring the multiple emulsion by magnetic force at room temperature so as to remove the organic solvent in the organic phase by volatilizing, performing centrifugal separation after nano-particles are solidified, washing the nano-particles with double distilled water so as to obtain the composite nano-carrier capable of loading nucleic acid drugs.
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Property | Measurement | Unit |
Particle size | 80.0 ~ 950.0 | nm |
Molecular weight | 1.0 ~ 100.0 | |
Molecular weight | 15.0 | |
tensile | MPa | |
Particle size | Pa | |
strength | 10 |
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