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Method for producing novel micro-fluidic chip based on industrial standard printed circuit board process

A technology of microfluidic chips and printed circuit boards, which is applied in the process of producing decorative surface effects, metal material coating process, decorative art, etc., and can solve the problem of high cost of etching molding method, long processing cycle, and low yield. Low-level problems, to achieve the effect of not easy to adsorb samples, low cost, and high yield

Inactive Publication Date: 2013-02-13
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The cost of etching molding method is too high, the yield is low, the processing cycle is long, and there are few domestic OEM units, and the connection with the external pipeline needs to be specially designed for special fixtures; the capillary glass tube assembly method is based on manual production and has poor repeatability ; The soft lithography casting method has good repeatability and is simple to manufacture, but because polymer materials such as PDMS are gas permeable and easy to deform, more importantly, PDMS is compatible with a variety of oil-phase organic solvents, making PDMS microfluidic chips applications are limited

Method used

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  • Method for producing novel micro-fluidic chip based on industrial standard printed circuit board process
  • Method for producing novel micro-fluidic chip based on industrial standard printed circuit board process
  • Method for producing novel micro-fluidic chip based on industrial standard printed circuit board process

Examples

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Effect test

Embodiment 1

[0032] Example 1. Production of oil-in-water microemulsion droplets by microfluidic chip with microfluidic convergence structure

[0033] Design the channel structure of the microfluidic chip as a microfluidic convergence structure, such as figure 2 As shown in 8, the width of the microchannel in this structure is 300 μm. figure 2 The middle shaded part is the copper-covered area, the white part is the microchannel formed after etching the copper layer, and the black part is the fluid inlet and outlet through hole. figure 2 The size of the middle and outer phase fluid inlet 6 and the inner phase fluid inlet 7 is 1.2 mm, and the size of the fluid outlet 10 is 3 mm. figure 2 The middle collection pool 9 is used to observe the generated microemulsion droplets, and its size is 18 mm×14 mm. The overall size of the PCB board of this design is 76.2 mm × 25.4 mm, which is the same size as a standard borosilicate glass slide. figure 1 According to the process flow, 650 microlite...

Embodiment 2

[0035] Example 2. Production of water-in-oil microemulsion droplets by microfluidic chip with microfluidic convergence structure

[0036] The microchannel structure of the microfluidic chip is designed as a microfluidic convergence structure, such as figure 2 As shown, the width of the microchannel in this structure is 150 microns. figure 2 The size of the middle and outer phase fluid inlet 6 and the inner phase fluid inlet 7 is 1.2 mm; the size of the fluid outlet 10 is 3 mm. The overall size of the PCB board of this design is 76.2 mm × 25.4 mm, which is the same size as a standard quartz glass slide. The thickness of the flexible copper clad foil substrate is 0.6 mm, the thickness of the copper clad is 15 microns, and the thickness of the gold plating is 2 microns. figure 1According to the process flow, 550 microliters of diluted UV-curable glue (the volume ratio of glue and ethanol is 1:1) is spin-coated on the surface of the glass slide with a glue leveling machine, and...

Embodiment 3

[0038] Embodiment 3, the making of parallel channel microfluidic chip

[0039] The process flow chart that this embodiment makes is as figure 1 shown 。

[0040] The designed microfluidic chip consists of four parallel channels with microfluidic convergence structures, such as Figure 4 as shown, Figure 4 The middle shaded part is the copper-covered area, the white part is the microchannel formed after etching the copper layer, and the black part is the fluid inlet and outlet through hole. The overall size of the PCB board of this design is 75 mm × 38 mm, which is the same size as another standard aluminum-magnesium glass slide. Micron, the size of the outer phase fluid inlet 6 and the inner phase fluid inlet 7 is 2 mm, according to figure 1 According to the technological process, 450 microliters of UV-curable glue is spin-coated on the surface of a glass slide using a glue leveling machine, the glue leveling speed is 5000 rpm, and the glue leveling time is 30 seconds. A...

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Abstract

The invention relates to a method for producing a novel micro-fluidic chip based on an industrial standard printed circuit board (PCB) process. The method comprises steps of designing a PCB copper-clad geometrical shape in accordance with a micro channel structure of the micro-fluidic chip; drawing a PCB picture in accordance with the copper-clad geometrical shape by using standard PCB design software; according to the PCB picture, obtaining a micro-fluidic chip body of the PCB through direct processing in a PCB factory; coating ultraviolet curing adhesive in a spin mode on a glass covering plate; agglutinating the copper-clad surface of the micro-fluidic chip body of the PCB with the adhesive-coating surface of the glass covering plate; and placing the agglutinated micro-fluidic chip body of the PCB and glass covering plate to an ultraviolet curing box for curing. An inlet and an outlet of the micro-fluidic chip and a micro channel are processed and formed, the standardization degree is high, the yield rate is high, the cost is low, the channel is applicable to an organic solvent, and the production environment is independent of ultra-clean and high-temperature conditions. The method is suitable to industrial large-scale batch production and scientific small-scale trial-production.

Description

technical field [0001] The invention relates to a method for manufacturing a novel microfluidic chip suitable for preparing microemulsion droplets, and belongs to the technical field of microfluidic chip manufacturing. [0002] Background technique [0003] At present, the microfluidic system has become an important branch of the microelectromechanical system. It has the advantages of small size, small invalid volume, low power consumption, high control precision, and fast response speed. It is mainly used in biological detection, microemulsion forming, and advanced functions. material preparation etc. [0004] There are three main methods of manufacturing microfluidic chips, which are etching molding, soft lithography casting, and capillary glass tube assembly. The silicon-based microchannel process reported in Document 1 (Physics of Fluids, 2005, 17: 013601) is fabricated by bulk silicon etching process, with large aspect ratio and high processing precision, and the obta...

Claims

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Application Information

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IPC IPC(8): B81C1/00
Inventor 李疆邢帅董恩凯
Owner UNIV OF SCI & TECH BEIJING
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