Method for preparing p-hydroxyphenyl ethanol

Abstract

The invention provides a method for preparing p-hydroxyphenyl ethanol, relating to a preparation method of a compound. The method for preparing the p-hydroxyphenyl ethanol, provided by the invention, has the advantages of simplicity in operation, environmental friendliness, high yield, reusable catalyst and applicability to industrial production. The method comprises the steps of: putting p-hydroxyphenyl acetate serving as a raw material, a copper-based catalyst serving as a hydrogenation catalyst, and a reaction solvent in a reaction vessel, replacing air in the reaction vessel with nitrogen gas and hydrogen gas respectively, and then, reacting; and carrying out depressurized spin drying on a solution after reacting, recovering the reaction solvent so as to obtain white solids, recrystallizing by using chloroform so as to obtain colorless needle-like crystals, filtering out precipitated crystals, washing filter cakes with water, and then, carrying out vacuum drying, thereby obtaining the p-hydroxyphenyl ethanol. The copper-based catalyst is used, so that the catalyst is little in consumption and can be reused; used solvents can be all recovered, so that the environmental protection and cost reduction are benefited; and the yield of the p-hydroxyphenyl ethanol is high and can reach over 80% at highest.

Description

Technical field [0001] The invention relates to a method for preparing a compound, in particular to a method for preparing p-hydroxyphenethyl alcohol by catalytic hydrogenation of p-hydroxyphenylacetate. Background technique [0002] P-Hydroxyphenethyl alcohol (also known as β-p-hydroxyphenethyl alcohol, tyrosol) is an important pharmaceutical and perfume intermediate, which can synthesize many useful drugs, such as betaolol, which is used to treat open-angle epioptic eye , Salidroside for the treatment of lung heat, cough and blast, and metoprolol for the treatment of hypertension and myocardial infarction. [0003] The methods for synthesizing p-hydroxyphenethyl alcohol include fermentation, 4-substituted phenol derivatives as raw materials, synthetic methods with aldehydes as intermediates, phenethylamine synthesis, phenethyl alcohol synthesis, and 4-substituted nitrosamine Base benzene is a raw material synthesis method and ester reduction method. The method disclosed in Chin...

AI Technical Summary

Problems solved by technology

The method disclosed in Chinese patent CN101225023A proposes to use ethyl p-hydroxyphenylacetate as a raw material, and obtain the corresponding alcohol by reducing the ester with lithium aluminum hydride or sodium borohydride at a low temperature, and the yield is 72%, but there are reducing agents that are relatively expensive and used in large quantities. shortcoming

The method disclosed in Chinese patent CN100432035C uses phenol and acetic anhydride as raw materials to prepare p-hydroxyphenethyl alcohol through three processes of esterification, haloalkylation and hydrolysis. Although the sources of raw materials are extensive, the process is complicated

In summary, although there are many methods for synthesizing p-hydroxyphenylethanol, there are generally disadvantages such as high cost, high requirements for reaction conditions, high risk of use, complicated process and low yield, making it difficult to realize industrialization