Molecular imprinting polymer filter paper for absorbing penicillin and preparation method thereof

A technology of molecular imprinting and penicillin, which is applied in the direction of alkali metal compounds, chemical instruments and methods, adsorption water/sewage treatment, etc., can solve problems such as inability to be directly applied, selectivity reduction, and adsorption capacity reduction, and achieve selectivity and multiple times Excellent recycling effect, improved adsorption capacity and selectivity, and convenient use

Inactive Publication Date: 2013-11-13
孟周翔
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, common molecularly imprinted polymers are block-like bulk polymers, which need to be crushed into powders and used after sieving and grading. This process will cause a lot of loss. In the column or adsorption tower, it cannot be directly applied, and the selectivity will be reduced during adsorption, and the powder will be lost during elution, resulting in a decrease in the adsorption capacity after multiple adsorptions

Method used

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  • Molecular imprinting polymer filter paper for absorbing penicillin and preparation method thereof
  • Molecular imprinting polymer filter paper for absorbing penicillin and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Accurately weigh 0.1 mmol template penicillin (C 16 h 18 N 2 o 4 S), 0.6 mmol functional monomer (the molar ratio of itaconic acid: acrylamide: 2-vinylpyridine = 1:1:1) was dissolved in a 15 mL centrifuge tube by adding 3 mL of acetonitrile, and left for 12 hours to make the template molecules and functional Monomer is fully functional. Add 0.036 mmol of initiator azobisisoheptanonitrile (ABVN) and 3 mmol of pentaerythritol tetramethacrylate to it, and nitrogen gas for 10 min after sonication to remove oxygen.

[0033] Take the qualitative filter paper and place it in a weighing bottle, weigh and record its mass, pour the above solution into the weighing bottle to ensure that the filter paper is completely soaked in the solution, shake the filter paper for 3 hours, then take out the filter paper and put it in a dry weighing bottle. In a measuring flask, sealed and placed in a constant temperature incubator at 60 °C for 12 h.

[0034] Then, use methanol / acetic acid ...

Embodiment 2

[0045]Accurately weigh 0.1 mmol template molecule penicillin, 0.6 mmol functional monomer (molar ratio of itaconic acid:acrylamide:2-vinylpyridine=1:1:0.5) into a 15 mL centrifuge tube, add 3 mL acetonitrile to dissolve, place 12h makes the template molecule fully interact with the functional monomer. Add 0.036 mmol of initiator azobisisoheptanonitrile (ABVN) and 3 mmol of pentaerythritol tetramethacrylate to it, and nitrogen gas for 10 min after sonication to remove oxygen.

[0046] Take qualitative filter paper in a weighing bottle, weigh and record its mass, pour the above solution into the weighing bottle to ensure that the filter paper is completely soaked in the solution, shake the shaker for 3 hours, take out the filter paper and put it in a dry weighing Bottles were sealed and placed in a constant temperature incubator at 60 °C for 12 h.

[0047] Then, use methanol / acetic acid (8:2, V / V) solution to wash away template molecules, unpolymerized monomers and cross-linkin...

Embodiment 3

[0054] Accurately weigh 0.1 mmol template molecule penicillin and 0.48 mmol functional monomer (molar ratio of itaconic acid:acrylamide:2-vinylpyridine=1:1.2:0.8) into a 15 mL centrifuge tube, add 3 mL acetonitrile to dissolve, place 12h makes the template molecule fully interact with the functional monomer. Add 0.06 mmol of initiator azobisisoheptanonitrile (ABVN) and 5 mmol of pentaerythritol tetramethacrylate to it, and nitrogen gas for 10 min after sonication to remove oxygen.

[0055] Take qualitative filter paper in a weighing bottle, weigh and record its mass, pour the above solution into the weighing bottle to ensure that the filter paper is completely soaked in the solution, shake the shaker for 3 hours, take out the filter paper and put it in a dry weighing Bottles were sealed and placed in a constant temperature incubator at 70 °C for 14 h.

[0056] Then, use methanol / acetic acid (8:2, V / V) solution to wash away template molecules, unpolymerized monomers and cross-...

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Abstract

The invention discloses a molecular imprinting polymer filter paper for absorbing penicillin. The filter paper is prepared by following steps: (1) dissolving penicillin and monomer in acetonitrile, sealing, standing still for at least 6 hours, adding an initiator and a cross-linking agent, introducing nitrogen to remove the oxygen in the solution; (2) putting a filter paper into the solution prepared in the step (1), oscillating for at least 3 hours, taking the filter paper out, putting the filter paper in a dry container, sealing the container, putting the container in a constant temperature incubator with a temperature of 50 to 80 DEG C, and having polymerization reaction for 8 to 24 hours; (3) putting the filter paper prepared in the step (2) into a mixed solution of methanol and acetic acid, oscillating, washing away the penicillin, non-polymerized monomers and cross-linking agent on the filter paper, soaking the filter paper in methanol, washing away acetic acid, and drying so as to obtain the molecular imprinting polymer filter paper for absorbing penicillin. The monomer is a mixture of itaconic acid, acrylamide and 2-vinylpyridine with a mol ratio of 1:1 to 1.5:0.5 to 1, and the cross-linking agent is pentaerythritol tetramethacrylate. The molecular imprinting polymer filter paper for absorbing penicillin is a cheap and high-efficient antibiotic absorption material.

Description

technical field [0001] The invention belongs to the field of environmental protection and relates to an efficient antibiotic adsorption material, in particular to a molecularly imprinted polymer filter paper for penicillin adsorption and a preparation method thereof. Background technique [0002] Penicillin is a class of widely used antibiotic drugs, not only used by human beings, but also widely used in the feed of livestock and aquatic products in the breeding industry. The abuse of antibiotics has caused serious pollution of surface water, and human beings have developed drug resistance after drinking water contaminated by antibiotics, which has a serious impact on human health. It is very necessary to develop adsorption materials that can efficiently adsorb antibiotic pollutants in surface water for water purification and pollution monitoring. [0003] Molecularly imprinted polymer is a kind of high-efficiency adsorption material, which uses the molecule to be adsorbed ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/28C02F1/28
Inventor 孟周翔
Owner 孟周翔
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