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Nano fiber whitening and freckle-removing mask paste

A spot mask and whitening technology, which is applied in the field of electrospinning and beauty and skin care, can solve the problems of easy inactivation of reduced glutathione and difficulty in achieving the expected whitening and repairing effect, and achieve safe and non-toxic processing technology and full efficacy Play the effect of simple and ingenious preparation process

Inactive Publication Date: 2013-12-18
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the combination of electrospinning technology and targeted drug delivery has made some progress. However, because reduced glutathione (GSH) is easily inactivated, there are few reports on electrospun fibers carrying GSH. Most of the glutathione products are mainly taken orally and injected. Firstly, after circulation in the body, the sulfhydryl group (-SH) of GSH combines with abundant free radicals in the body and is exhausted; secondly, because the concentration of GSH is diluted by body fluids, it can reach the spots Or there is very little glutathione in the trauma target area, so it is difficult to achieve the expected whitening and repairing effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1. Preparation of spinning solution:

[0024] a) Weigh 1,000 mg of PVP-K30 (average molecular weight = 40,000), dissolve it in 2 mL of absolute ethanol, seal it with a parafilm, and stir it magnetically for 1 hour to prepare a 50% (wt.%, the same below) PVP ethanol solution. stand-by.

[0025] b) Weigh 10 mg of GSH and vitamin C respectively, mix and dissolve in 100 μL of deionized water and oscillate at high frequency for 5 minutes to obtain a clear solution, immediately add it to the PVP ethanol solution described in step a and continue stirring until uniform to obtain a dispersed Homogeneous final mixed solution of GSH-vitamin C nanoparticles.

[0026] 2. Mask stick preparation process:

[0027] Electrospin the mixed solution obtained in step 1, set the spinning rate to 0.7mL / h, and the voltage to 15kV, and receive the electrospun fibers with ultra-thin cotton cloth. After 1 hour, it will form a sheet of about 15×15cm 2 nanofiber anti-freckle whitening mask.

...

Embodiment 2

[0031] 1. Preparation of spinning solution:

[0032] c) Weigh 300 mg of PVA (average molecular weight = 75,000), dissolve it in 1 mL of deionized water, seal it with a parafilm, stir magnetically at 80°C for 3 hours, then add 1 mL of absolute ethanol and oscillate evenly to prepare a 15% PVP ethanol aqueous solution (ethanol / water, 1 / 1), set aside.

[0033] d) Weigh 10 mg of GSH and catechin respectively, mix and dissolve in 100 μL deionized water and oscillate at high frequency for 5 minutes to obtain a clear solution, immediately add it to the PVP ethanol solution described in step a and continue to stir until uniform, and obtain a solution containing The final mixed solution of uniformly dispersed GSH-catechin nanoparticles.

[0034] 2. Mask stick preparation process:

[0035] Electrospin the mixed solution obtained in step 1, set the spinning rate to 0.7mL / h, and the voltage to 15kV, and receive the electrospun fibers with ultra-thin cotton cloth. After 1 hour, it wil...

Embodiment 3

[0039] 1. Preparation of spinning solution:

[0040] e) Weigh 100 mg of PEO (average molecular weight = 100,000) and carboxylated chitosan (average molecular weight = 30,000) respectively, dissolve them in 2 mL of acetic acid aqueous solution (acetic acid / water, 1 / 1), seal with a parafilm, and magnetically Stir for 1 hour to prepare 10% PEO / water-soluble chitosan in acetic acid aqueous solution (acetic acid / water, 1 / 1) for use.

[0041] f) Weigh 10 mg of GSH and 1 mg of astaxanthin respectively, mix and dissolve in 100 μL of deionized water and oscillate at high frequency for 5 minutes to obtain a uniform solution, and immediately add it to the acetic acid of PEO / water-soluble chitosan described in step a aqueous solution and continue to stir until uniform to obtain a final mixed solution containing uniformly dispersed GSH-astaxanthin nanoparticles.

[0042] 2. Mask stick preparation process:

[0043]Electrospin the mixed solution obtained in step 1, set the spinning rate ...

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Abstract

The invention discloses a nano fiber whitening and freckle-removing mask paste. The nano fiber whitening and freckle-removing mask paste comprises a spinning solution and cotton cloth, wherein active components of the spinning solution are reduced glutathione and an anti-oxidizing auxiliary material; the mass ratio of the reduced glutathione to the anti-oxidizing auxiliary material is equal to 1-10. According to the nano fiber whitening and freckle-removing mask paste, whitening and freckle-removing effective components are the reduced glutathione (GSH) and the anti-oxidizing auxiliary material, wherein the GSH is dispersed into a nano fiber in a nano particle manner; the anti-oxidizing auxiliary material can keep a reduced state of an active radical sulfhydryl (-SH) in the GSH and the biological activity is kept. The reduced glutathione inhibits the activity of tyrosinase, eliminates active oxygen or free radicals, treats radiation diseases and carries out radiation protection, so as to inhibit the formation of melanin; the reduced glutathione is combined with an electrostatic spinning technique to realize advantage complementation.

Description

technical field [0001] The invention relates to the fields of electrospinning and beauty and skin care, and more specifically, relates to an electrospinning nanofiber whitening and freckle-removing facial mask. Background technique [0002] Electrospinning is a processing technology that stretches a polymer solution or melt by electrostatic force to produce a Taylor cone, and sprays and stretches it into ultrafine fibers. The superfine fibers produced by this technology have a large specific surface area and a very high aspect ratio. Some natural and synthetic polymers have been widely used in nanotechnology-related fields such as tissue engineering; glutathione is a substance that exists in all living cells. Medium and oligopeptides with important physiological functions, composed of glutamic acid, cysteine, and glycine, divided into reduced glutathione (GSH) and oxidized glutathione (GSSG). In vivo, reduced glutathione (GSH) is the major active state, accounting for appro...

Claims

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Application Information

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IPC IPC(8): A61K8/64A61K8/67A61Q19/02
Inventor 蒋庆冯章启任卓卓靳林
Owner SUN YAT SEN UNIV
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