Bismuth sulfide-based multifunctional probe for CT and fluorescence dual-mode imaging

Abstract

The invention provides a multifunctional probe for CT (Computed Tomography) and dual-mode fluorescent imaging based on nanometer bismuth sulfide. The multifunctional probe is formed by nanosilicon dioxide encapsulated nanometer bismuth sulfide and oil-soluble CdSe / ZnS quantum dots; the nanometer bismuth sulfide is selected as a CT (Computed Tomography) contrast medium part, and the oil-soluble CdSe / ZnS quantum dots are used as an optical probe part. Firstly, bismuth sulfide synthesized by a reversed-phase microemulsion method is used as a core, the oil-soluble CdSe / ZnS quantum dots are added in the system, tetraethyl orthosilicate is utilized for hydrolysis to obtain SiO2, and the nanometer bismuth sulfide and the oil-soluble CdSe / ZnS quantum dots are encapsulated in the nanometer SiO2 to obtain the multifunctional probe for CT and dual-mode fluorescent imaging, which is uniform in size and has good stability. The multifunctional probe with the dual-mode imaging function utilizes the CT contrast medium to accurately locate deep tissues, so as to make up the defect of optical molecular imaging deficiency.

Description

Technical field [0001] The invention belongs to the fields of biological and medical nanotechnology and material science, and relates to CT and fluorescent contrast agents, in particular to a multifunctional probe for CT and fluorescent dual-mode imaging and a preparation method thereof. Background technique [0002] In recent years, medical imaging methods such as CT, MRI, X-ray imaging and ultrasound imaging have played an important role in the research and application of clinical medicine and related fields. At the same time, optical imaging technology has high sensitivity and ultra-fast response. The advantages of high spatial resolution, multi-parameter detection and low damage have attracted more and more attention. Since various imaging methods have different imaging advantages and disadvantages due to their different imaging principles, no single imaging technology can meet the comprehensive and complete diagnosis of complex diseases. Therefore, a dual-mode or even multi-...

AI Technical Summary

Problems solved by technology

[0004] A single imaging contrast agent can only be used for the corresponding imaging equipment, resulting in incomplete and inaccurate diagnostic information

When CT and fluorescence imaging technologies are used alone, the spatial resolution is not high and the imaging depth is limited, resulting in incomplete and inaccurate detection information of complex diseases, and the detection information of the same part is not synchronized, that is, CT contrast agents and optical imaging agents are different due to their respective properties Different from the circulation time in the body, the time of CT and optical imaging is different, and the diagnostic information obtained is not comprehensive. By the time the spleen is shown on optical imaging, the opportunity for contrast imaging of the spleen in CT imaging has long been missed, and the combination of existing CT contrast agents and optical imaging agents has problems such as low CT values.

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