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Cefpirome sulfate composition freeze-dried powder injection for injection

A technology of cefpirome sulfate and freeze-dried powder injection, which is applied in the field of medicine and medicine manufacturing, can solve the problems of insensitivity of β-lactamase bacteria and poor curative effect, achieve the elimination of activity, maintain internal circulation, and have biological compatibility effect

Inactive Publication Date: 2014-02-05
HAINAN WEI KANG PHARMA QIANSHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The object of the present invention is aimed at the cefpirome antimicrobial drug containing a single component, which is insensitive to β-lactamase bacteria and has poor curative effect, and provides a cefpirome antibacterial drug with a wider antibacterial spectrum and stronger antibacterial effect Compositions and pharmaceutical preparations thereof

Method used

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  • Cefpirome sulfate composition freeze-dried powder injection for injection
  • Cefpirome sulfate composition freeze-dried powder injection for injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1, the preparation of cefpirome sulfate composition freeze-dried powder for injection, in 1000 pieces.

[0030] prescription:

[0031] Cefpirome Sulfate 500g

[0032] Chitosan Nanoparticles 300g

[0033] Water for injection 2000ml

[0034] 2. Preparation process:

[0035] The chitosan nanoparticles that take 300g are slowly added in the water for injection of 2000ml, stir to dissolve while adding.

[0036] Add 500 g of cefpirome sulfate and stir to dissolve until clear.

[0037] Adjust the pH to 5.1 with buffer salts of sodium dihydrogen phosphate and disodium hydrogen phosphate, add 0.1% activated carbon and stir for 30 minutes, filter out the activated carbon, filter the liquid through 0.45 μm and 0.22 μm microporous membranes, and detect the content of intermediates , according to cefpirome sulfate 0.5g per bottle to calculate the loading.

[0038] Fill according to the test requirements, put it into a freeze dryer after half-tamping, cool down to -4...

Embodiment 2

[0039] Embodiment 2, preparation of cefpirome sulfate composition freeze-dried powder for injection, in 1000 pieces.

[0040] 1. Prescription:

[0041] Cefpirome Sulfate 500g

[0042] Chitosan Nanoparticles 332g

[0043] Water for injection 2000ml

[0044] 2. Preparation process:

[0045] The chitosan nanoparticle that takes by weighing 332g is slowly added in the water for injection of 2000ml, stirs while adding to dissolve.

[0046] Add 500 g of cefpirome sulfate and stir to dissolve until clear.

[0047] Adjust the pH to 5.1 with buffer salts of sodium dihydrogen phosphate and disodium hydrogen phosphate, add 0.1% activated carbon and stir for 30 minutes, filter out the activated carbon, filter the liquid through 0.45 μm and 0.22 μm microporous membranes, and detect the content of intermediates , according to cefpirome sulfate 0.5g per bottle to calculate the loading.

[0048] Fill according to the test requirements, put it into a freeze dryer after half-tamping, cool...

Embodiment 3

[0049] Embodiment three, the preparation of cefpirome sulfate composition freeze-dried powder for injection, in 1000 pieces.

[0050] prescription:

[0051] Cefpirome Sulfate 500g

[0052] Chitosan Nanoparticles 289g

[0053] Water for injection 2000ml

[0054] 2. Preparation process:

[0055] The chitosan nanoparticle that takes by weighing 289g is slowly added in the water for injection of 2000ml, stirs while adding to dissolve.

[0056] Add 500 g of cefpirome sulfate and stir to dissolve until clear.

[0057] Adjust the pH to 5.1 with buffer salts of sodium dihydrogen phosphate and disodium hydrogen phosphate, add 0.1% activated carbon and stir for 30 minutes, filter out the activated carbon, filter the liquid through 0.45 μm and 0.22 μm microporous membranes, and detect the content of intermediates , according to cefpirome sulfate 0.5g per bottle to calculate the loading.

[0058] Fill according to the test requirements, put it into a freeze dryer after half-tamping,...

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Abstract

The invention provides a cefpirome sulfate composition freeze-dried powder injection for injection, and relates to the technical field of medicines and medicine preparation. The cefpirome sulfate composition freeze-dried powder injection for injection comprises the following raw material components in parts by weight: 7.26-9.17 parts of cefpirome sulfate, 4.36-5.50 parts of chitosan nanoparticles and 84.38-89.10 parts of water for injection. The cefpirome sulfate composition freeze-dried powder injection for injection has the advantages that 1) the chitosan nanoparticles occupy the active center of beta-lactamase, so that the beta-lactamase in drug-resistance bacteria is deactivated, the antibacterial spectrum of cefpirome is widened and the antibacterial activity of cefpirome is remarkably enhanced; 2) the chitosan nano carrier material has biocompatibility, biodegradability and non-toxicity; 3) the composition can maintain body circulation for a longer time; 4) the chitosan nanoparticles can replace mannitol as a freeze-dried skeleton agent of the freeze-dried powder injection, so that the activity of mannitol on a human body is eliminated.

Description

Technical field: [0001] The invention relates to the technical field of medicine and medicine manufacture, in particular to a cefpirome sulfate composition freeze-dried powder for injection. Background technique: [0002] Cefpirome is the fourth-generation cephalosporin antibiotic, which is effective against Gram-positive bacteria such as Streptococcus (except Streptococcus faecalis), Streptococcus pneumoniae, Escherichia coli, Haemophilus influenzae, Klebsiella, and Salmonella , Shigella, Neisseria gonorrhoeae and other Gram-negative bacteria have strong antibacterial activity, especially Serratia, indole-positive Proteus, Enterobacter and citric acid with low sensitivity to cephalosporins The antibacterial activity of bacteria is more obvious. At the same time, the antibiotic is unstable to the β-lactamase produced by bacteria, but is ineffective against drug-resistant microorganisms such as Pseudomonas, Mycoplasma, Chlamydia, and Enterococcus. [0003] So far, cefpirome...

Claims

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Application Information

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IPC IPC(8): A61K9/19A61K31/546A61K47/36A61P31/04
Inventor 汪六一汪金灿林立
Owner HAINAN WEI KANG PHARMA QIANSHAN
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