Nudihuazizhu sustained-release pellets and its preparation method and application
A technology of naked flower purple beads and sustained-release pellets, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, block delivery, etc., can solve the problem of safety, effectiveness, quality control, and no substantial innovation. In order to reduce the frequency of taking medicine, the preparation method is scientific and reasonable, and the fluctuation and side effects are reduced.
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Embodiment 1
[0036] Nudehuazizhu sustained-release pellets are prepared according to the following prescription and steps:
[0037] a. Add 100g of Auranthus nudiflora extract plus 60g of filler microcrystalline cellulose and 20g of lactose, mix well, spray 3% polyvinylpyrrolidone k30 60% ethanol solution as binder solution, and prepare pellets by centrifugal granulation , select pellets with a particle size of 0.60 mm to 0.80 mm, and dry to obtain a pellet core;
[0038] b. The coating prescription is as follows: 40 g of ethyl cellulose N10, 4 g of triethyl citrate, 20 g of polyethylene glycol 6000, 40 g of talcum powder, and 1300 mL of 85% ethanol is added to make a coating liquid, and the pills containing The core is coated with a fluidized bed, and dried under vacuum at 0.1MPa for 24 hours at 40°C to obtain nudehuazizhu sustained-release pellets. The weight gain of the coating is 20% of that of the core.
Embodiment 2
[0040] Nudehuazizhu sustained-release pellets are prepared according to the following prescription and steps:
[0041] a. Add 50g of Auranthus nudiflora water extract, 100g of filler microcrystalline cellulose, and 30g of starch, mix well, spray 5% polyvinylpyrrolidone K30, 60% ethanol solution as binder solution, and prepare by centrifugal granulation Pellets, the size of the pellets is 0.45-0.78mm, dried to contain pill cores;
[0042] b. The coating prescription is as follows: ethyl cellulose N10 50g, medium chain triglyceride 3g, oleic acid 2g, hydroxypropyl methylcellulose 15g, talcum powder 20g, micropowder silica gel 15g, add 90% ethanol 900ml to make a bag Coating liquid, the drug-containing pellet core is coated with a fluidized bed, and vacuum-dried at 40°C for 24 hours to obtain nudehuazizhu sustained-release pellets, and the weight gain of the coating is 15% of the pellet core.
Embodiment 3
[0044] Nudehuazizhu sustained-release pellets are prepared according to the following prescription and steps:
[0045] a. Add 80g of Asteria nudica alcohol extract plus 80g of filler microcrystalline cellulose and 40g of mannitol, mix well, spray 5% polyvinylpyrrolidone K30, 60% ethanol solution as binder solution, and use centrifugal granulation method Prepare micropills, the size of the micropills is 0.65-1.05mm, and dry to obtain the core of the pill;
[0046] b. The coating prescription is as follows: ethyl cellulose N10 50g, citrate triester 4g, oleic acid 2g, polyethylene glycol 15g, talcum powder 20g, micropowder silica gel 20g, add 1200ml of 90% ethanol to prepare coating solution, and The drug-containing pellet cores are coated in a fluidized bed, and vacuum-dried at 40°C for 24 hours to obtain nudihuazizhu sustained-release pellets. The weight gain of the coating is 40% of the core pellets.
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