Preparation method of D,L-2-hydroxy-4-methylthiobutyric acid-trace element chelate
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A technology of methylthiobutyric acid and methylthiobutyrate, which is applied in the field of chemical industry, can solve the problems of difficult trace metal element reaction, destruction of nutrient components, high price, etc.
Active Publication Date: 2014-03-19
NINGXIA UNISPLENDOUR TIANHUA METHIONINE CO LTD
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[0003] (1) It has a strong corrosive and pungent odor, and it is inconvenient to store, transport and use, so it is necessary to use an expensive special liquid feeding system;
[0004] (2) It is very viscous, and it is not easy to mix evenly in the feed premix;
[0005] (3) A large amount of heat is released when it comes into contact with water, causing the feed to heat up and ferment and become rancid during storage and transportation; the acidity is very high, with a pH of about 1, and it is easy to react with feed or other ingredients in the premixed feed. Nutrients cause damage
But this production process production cost is all higher, specifically, in order to obtain high yield, all needs purer hydrocyanic acid, and hydrocyanic acid is often excessive, the additional rectification purific
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Embodiment 1
[0046] The hydrocyanic acid mixed gas I from the hydrocyanic acid synthesis tower was detected. The composition of the hydrocyanic acid mixed gas I was: 8.87% hydrocyanic acid gas, 3.88% water vapor, 1.64% ammonia gas, 1.13% hydrogen gas, nitrogen gas 76.01%, oxygen 1.48%, carbon monoxide 5.67%, carbon dioxide 1.13%, methane 0.39%.
[0047] Hydrocyanic acid mixed gas I passes through a 75% sulfuric acid tower to absorb ammonia and water vapor in the mixed gas, and the composition of the obtained hydrocyanic acid mixed gas II is: 9.35% hydrocyanic acid gas, 1.57% hydrogen gas, and 79.44% nitrogen gas %, oxygen 1.71%, carbon monoxide 5.79%, carbon dioxide 1.50%, methane 0.64%.
Embodiment 2
[0049] Pass hydrogen cyanide mixed gas II into 223.3g of 94.5% methional with a mass fraction of 223.3g, which contains 3.3g of pyridine. React under normal pressure, control the reaction temperature to 45°C, the ventilation rate to 300L / min, absorb the tail gas with sodium hydroxide, and monitor the residual amount of methionaldehyde by HPLC. When the residual amount of methionaldehyde is less than 0.5%, it is the end of the reaction, and the feeding can be stopped. A total of 270.64 g of light yellow liquid was obtained, the content of 2-hydroxy-4-methylthiobutyronitrile was 98%, and the residual hydrocyanic acid was 0.5%.
Embodiment 3
[0051] Pass hydrogen cyanide mixed gas II into 223.3g of methional with a mass fraction of 94.5%, which contains 2.2g of pyridine and 10g of water. Under 0.15MPa, the reaction temperature is controlled to be 42°C, the ventilation rate is 280L / min, the tail gas is absorbed with sodium hydroxide, and the residual amount of methional is monitored by HPLC. When the residual amount of methionaldehyde is less than 0.5%, it is the end of the reaction, and the feeding can be stopped. A total of 279.54 g of light yellow liquid was obtained, the content of 2-hydroxy-4-methylthiobutyronitrile was 98%, and the residual hydrocyanic acid was 0.07%.
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Abstract
The invention aims at the chemical industry field, and relates to a preparation method of a D,L-2-hydroxy-4-methylthiobutyric acid-trace element chelate. The method comprises the following steps: preparing a hydrocyanic acid mixed gas by adopting an Andrussow process, and reacting the hydrocyanic acid mixed gas with methylthiopropionaldehyde to obtain a 2-hydroxy-4-methylthiobutyronityile system, hydrolyzing the 2-hydroxy-4-methylthiobutyronityile system by an inorganic alkali to obtain D,L-2-hydroxy-4-methylthiobutyrate, and chelating the D,L-2-hydroxy-4-methylthiobutyrate with a trace metal element salt to generate the D,L-2-hydroxy-4-methylthiobutyric acid-trace element chelate. The method has the advantages of few technological steps, cheap and easily available raw materials, stable properties of the above intermediate, and low total production cost; the obtained D,L-2-hydroxy-4-methylthiobutyric acid-trace element chelate has the advantages of high yield, high purity and large bulk density; and the D,L-2-hydroxy-4-methylthiobutyric acid-trace element chelate can be effectively mixed with feeds as an animal feed additive to supplement trace elements and amino acids in the daily ration and improve the endozoic production and immunity performances, and can also be used as a medicinal reagent.
Description
technical field [0001] The present invention is aimed at the field of chemical engineering, and relates to a preparation method of D,L-2-hydroxy-4-methylthiobutyric acid trace element chelate, in particular to a method for preparing D,L-2-hydroxy-4-methylthiobutyric acid A method for preparing D,L-2-hydroxy-4-methylthiobutyric acid trace element chelate based on the salt preparation method. Background technique [0002] Methionine hydroxy analogue (MHA), also known as D,L-2-hydroxy-4-methylthiobutyric acid, is a methionine additive with low toxicity, low rumen degradation rate, promotion of rumen microbial synthesis, and saving in dietary It is the most economical and effective amino acid source for animals, with the characteristics of high protein, improving the production performance of dairy cows, improving the production performance and immunity of animals, reducing ammonia emissions, less polluting the environment, simple production process, and low price. Although met...
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IPC IPC(8): C07C323/52C07C319/20
Inventor 吴传隆朱晓莉王用贵秦岭朱丽利任星宇陈宏杨李欧
Owner NINGXIA UNISPLENDOUR TIANHUA METHIONINE CO LTD
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