Preparation method of d,l-2-hydroxy-4-methylthiobutyric acid trace element chelate

Abstract

The invention aims at the chemical industry field, and relates to a preparation method of a D,L-2-hydroxy-4-methylthiobutyric acid-trace element chelate. The method comprises the following steps: preparing a hydrocyanic acid mixed gas by adopting an Andrussow process, and reacting the hydrocyanic acid mixed gas with methylthiopropionaldehyde to obtain a 2-hydroxy-4-methylthiobutyronityile system, hydrolyzing the 2-hydroxy-4-methylthiobutyronityile system by an inorganic alkali to obtain D,L-2-hydroxy-4-methylthiobutyrate, and chelating the D,L-2-hydroxy-4-methylthiobutyrate with a trace metal element salt to generate the D,L-2-hydroxy-4-methylthiobutyric acid-trace element chelate. The method has the advantages of few technological steps, cheap and easily available raw materials, stable properties of the above intermediate, and low total production cost; the obtained D,L-2-hydroxy-4-methylthiobutyric acid-trace element chelate has the advantages of high yield, high purity and large bulk density; and the D,L-2-hydroxy-4-methylthiobutyric acid-trace element chelate can be effectively mixed with feeds as an animal feed additive to supplement trace elements and amino acids in the daily ration and improve the endozoic production and immunity performances, and can also be used as a medicinal reagent.

Description

technical field [0001] The present invention is aimed at the field of chemical engineering, and relates to a preparation method of D,L-2-hydroxy-4-methylthiobutyric acid trace element chelate, in particular to a method for preparing D,L-2-hydroxy-4-methylthiobutyric acid A method for preparing D,L-2-hydroxy-4-methylthiobutyric acid trace element chelate based on the salt preparation method. Background technique [0002] Methionine hydroxy analogue (MHA), also known as D,L-2-hydroxy-4-methylthiobutyric acid, is a methionine additive with low toxicity, low rumen degradation rate, promotion of rumen microbial synthesis, and saving in dietary It is the most economical and effective amino acid source for animals, with the characteristics of high protein, improving the production performance of dairy cows, improving the production performance and immunity of animals, reducing ammonia emissions, less polluting the environment, simple production process, and low price. Although met...

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Problems solved by technology

[0003] (1) It has a strong corrosive and pungent odor, and it is inconvenient to store, transport and use, so it is necessary to use an expensive special liquid feeding system;

[0004] (2) It is very viscous, and it is not easy to mix evenly in the feed premix;

[0005] (3) A large amount of heat is released when it comes into contact with water, causing the feed to heat up and ferment and become rancid during storage and transportation; the acidity is very high, with a pH of about 1, and it is easy to react with feed or other ingredients in the premixed feed. Nutrients cause damage

But this production process production cost is all higher, specifically, in order to obtain high yield, all needs purer hydrocyanic acid, and hydrocyanic acid is often excessive, the additional rectification purification of hydrocyanic acid and excessive use All will cause an increase in cost, and this increase in cost, especially on an industrial scale, will lead to huge economic losses; moreover, the unsuitability of the reaction system will also increase the burden of subsequent purification and separation, reducing the yield of the product

[0011] In addition, since the commercially available D,L-2-hydroxy-4-methylthiobutyric acid is a mixture, which contains about 22% of dimers and their polymers, and these polymers are mostly esters or anhydrides Exist in the form of these polymers, making it difficult for these polymers to react with trace metal elements, and finally adsorbed on the surface of the product, making it difficult to dry the product, which in turn affects the quality of the product

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