Macrocyclic polyphenol compound, and preparation and application thereof in pharmacy

A technology of polyphenolic compounds and compounds, applied in the preparation of sugar derivatives, sugar derivatives, sugar derivatives, etc., can solve the pharmacological reports of compounds that have not been seen in reducing blood sugar and anti-hepatic fibrosis, etc., to achieve inhibition of hepatic stellate Cell proliferation, rich sources of raw materials, and environmental protection
CN103641871AActive Publication Date: 2014-03-19SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
0 Cites 12 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Publication Date
2014-03-19

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention provides a new use of a macrocyclic polyphenol compound separated from a penthorum chinense pursh extract in pharmacy. The macrocyclic polyphenol compound comprises a compound 1, a compound 2, a compound 3 and a compound 4, wherein the structural formulas of the compounds are as shown in the specification; the compounds have the following pharmacological activities that (1) the alpha-amylase activity is significantly inhibited, and the compounds have certain hypoglycemic effects, and (2) TGF (transforming growth factor)-beta1-induced hepatic stellate cell proliferation is significantly inhibited, and the compounds have anti-liver-fibrosis effects by pharmacology and efficacy experiments. The invention provides a novel medicament for preventing and treating diabetes mellitus, and an anti-liver fibrosis medicament. The medicament is abundant in raw material source, small in side effect, and beneficial to environmental protection, and has a relatively great clinical application value.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The present invention relates to traditional Chinese medicines, in particular to the use of traditional Chinese medicines, in particular to macrocyclic polyphenol compounds and their preparation and use in the preparation of medicines for preventing and treating diabetes and liver fibrosis. Background technique

[0002] Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia caused by various etiologies. With the change of human life style, the incidence of diabetes is gradually increasing, and it is expected to reach 300 million people by 2025, seriously endangering human health and social development. Abnormal glucose metabolism is the main pathological factor of diabetes, and the related enzymes involved in glucose metabolism have an important impact on glucose metabolism. Diabetes research progress, Chinese Journal of Traditional Chinese Medicine, 2012, 37(23): 3519-3525). Hypoglycemic drugs usually include traditional Ch...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More