Cellulose micro-sphere with uniform size as well as preparation method and application thereof

A technology of cellulose microspheres and cellulose, applied in the direction of microsphere preparation, microcapsule preparation, chemical instruments and methods, etc., can solve the problems of limited application range, uneven particle size of cellulose microspheres, etc., and achieve good repeatability , Conducive to environmental protection, easy to operate

Inactive Publication Date: 2014-04-30
WUHAN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The cellulose microspheres prepared by these methods are often very uneven in particle size, which greatly limits their application range.

Method used

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  • Cellulose micro-sphere with uniform size as well as preparation method and application thereof

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preparation example Construction

[0026] The preparation process of cellulose microspheres is as follows:

[0027] Dissolving cellulose in alkali / urea aqueous solution or alkali / thiourea aqueous solution at -12 to -5°C, centrifuging to defoam and remove impurities to obtain a cellulose solution as the water phase.

[0028] The oil-soluble emulsifier is dissolved in the oily liquid at a volume ratio of 0-10% as the oil phase. Wherein, the oil-soluble emulsifier is selected from any one of Span 80, Span 60, Tween 80, oleic acid, and potassium oleate or mixed arbitrarily; or no emulsifier is added. The oily liquid is any one or any mixture of kerosene, transformer oil, pump oil, 200# gasoline, turbine oil, liquid paraffin, petroleum ether, soybean oil, rapeseed oil.

[0029] Take the oil phase: the volume ratio of the water phase is 1:3-1:25, and press the water phase into the oil phase through the hydrophobic porous membrane to obtain the W / O emulsion; under the condition of stirring, add the solidification liq...

Embodiment 1

[0034] The hydrophobic membrane with a pore size of 0.3 μm is immersed in a lipophilic substance to fully wet the porous membrane to ensure that the hydrophobic chains on the membrane are completely stretched. Precool NaOH / urea aqueous solution to -12°C as a solvent to dissolve cellulose and centrifuge to defoam and remove impurities to prepare a cellulose solution with a concentration of 4wt%. Stir 2.4ml of the above cellulose solution for 30 minutes and sonicate for 10 minutes as the water phase spare. Add 6ml of Span 80 into 60ml of the mixed oil phase of liquid paraffin and petroleum ether, and stir until completely dissolved as the oil phase. Press 2.4ml of the water phase into the oil phase through a hydrophobic microporous membrane with uniform pore size under constant pressure to obtain a W / O emulsion. A certain amount of dilute hydrochloric acid solidification solution was slowly added dropwise to the obtained emulsion at a rotational speed of 600 rpm, and the solidi...

Embodiment 2

[0036] The hydrophobic membrane with a pore size of 1 μm is soaked in a lipophilic substance, so that the porous membrane is fully wetted to ensure that the hydrophobic chains on the membrane are completely stretched. Use NaOH / urea aqueous solution to pre-cool to -12°C as solvent to dissolve cellulose and centrifuge to defoam and remove impurities to prepare a cellulose solution with a concentration of 4wt%. Stir 7ml of the above cellulose solution for 30 minutes, ultrasonic for 10 minutes, and use it as the water phase for later use . Add 2.5ml of oleic acid / potassium oleate compound emulsifier into 60ml of the mixed oil phase of liquid paraffin and gasoline, and stir until completely dissolved as the oil phase. Press 7ml of the water phase into the oil phase through a hydrophobic microporous membrane with uniform pore size under constant pressure to obtain a W / O emulsion. A certain amount of dilute hydrochloric acid solidification solution was slowly added dropwise to the o...

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Abstract

The invention discloses a cellulose micro-sphere with a uniform size as well as a preparation method and an application thereof. According to the cellulose micro-sphere, the diameter distribution coefficient is less than 10% and the grain diameter ranges from 500 nanometers to 150 microns; the cellulose micro-sphere is prepared by the following manner: cellulose is dissolved into an alkali / urea water solution or an alkali / thiourea water solution at temperature from -12 DEG C to -5 DEG C; centrifuging and de-foaming, and removing impurities to obtain a cellulose solution which is used as a water phase; dissolving an oil-soluble emulsifying agent into oily liquid according to a volume ratio of 0-10% to obtain an oil phase; pressing the water phase into the oil phase by a hydrophobic porous membrane to obtain W / O emulsion; under an agitating condition, adding a curing solution into the W / O emulsion, and separating and washing to obtain the cellulose micro-sphere. The preparation method is convenient to operate, low in cost and good in repeatability and is suitable for large-scale preparation of the cellulose micro-spheres; the prepared cellulose micro-spheres are uniformly dispersed, have uniform size and are not easy to agglomerate; the cellulose micro-spheres can be used as medicines, macromolecular carriers, adsorbents and chromatographic column fillers.

Description

technical field [0001] The invention belongs to the technical field of functional materials, in particular to a cellulose microsphere with uniform size and its preparation method and application Background technique [0002] Science and technology in the 21st century have tended towards renewable raw materials, environmentally friendly and sustainable processes and methods. There is growing interest in biodegradable and biocompatible materials prepared from renewable resources. Cellulose is the most widely distributed and most abundant polysaccharide in nature, and is the main component of plant cell walls. Cotton, flax, taro and jute contain a lot of high-quality cellulose. The cellulose content of wood is about 50%, and the cellulose content of cotton is higher, reaching 90%. Cellulose in wood often exists together with hemicellulose and lignin. Cellulose is cheap, biocompatible, degradable and does not pollute the environment. Therefore, all countries in the world att...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L1/02C08J3/16B01J13/02B01J20/24B01J20/28B01J20/281A61K47/38
Inventor 罗晓刚喻发全薛亚楠蔡宁朱三张浩曹珍妮
Owner WUHAN INSTITUTE OF TECHNOLOGY
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