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Antibacterial modified chitosan foaming agent and preparation method thereof

A chitosan and foaming agent technology, which is applied in the directions of topical antibacterial agents, pharmaceutical formulations, and aerosol delivery, can solve the problems of many varieties of drug dressings, complicated production processes, and complicated production methods, and achieves improved antibacterial broad-spectrum performance. , the physical properties are stable, and the effect of improving biological safety

Active Publication Date: 2014-09-17
JIANGSU RUIJING TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] These technologies have the following technical defects: one, they all use propellant aerosols including propane, butane or isobutane, halogenated hydrocarbons, two, there are many kinds of medical dressings added, and the manufacturing process is complicated; three, although chitosan Sugar is the main matrix, but other antibacterial ingredients are added, such as Yujiexin, nano silver, borneol, menthol and other ingredients
[0008] The purpose of the present invention is to overcome the shortcoming that exists in the prior art, solve the problems such as lacking pure chitosan environmental protection, high-efficiency foaming agent, complicated production method at present, propose a kind of preparation method of modified chitosan antibacterial foaming agent, obtain The foam agent has a fine foam structure, good broad-spectrum antibacterial effect, can promote the recovery of lesion cells, and the preparation and application methods are simple, and can be conveniently used in the treatment and nursing of various vaginitis in clinical gynecology.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] Embodiment 1: prepare antibacterial modified chitosan foam agent

[0093] The implementation steps of this embodiment are as follows:

[0094] A, preparation of modified chitosan

[0095] To be sold by Jinan Haidebei Marine Bioengineering Co., Ltd. under the trade name of food and pharmaceutical grade chitosan, with a deacetylation degree of 70% and a molecular weight of 30×10 4 The chitosan of Da, dissolves 15min under the condition of stirring speed 250rpm in 2% acetic acid aqueous solution by weight, the solution that obtains is in the ultrasonic cleaning machine sold by trade name YD1008 ultrasonic cleaning machine by Changzhou Youda Ultrasonic Equipment Co., Ltd. In the process, ultrasonic treatment was carried out for 45 minutes under the conditions of ultrasonic frequency 20kHz and power 200W, and then the polyvinylidene fluoride ultrafiltration membrane sold by the American KENKER company under the trade name polyvinylidene fluoride membrane was used for classi...

Embodiment 2

[0105] Embodiment 2: prepare antibacterial modified chitosan foam agent

[0106] The implementation steps of this embodiment are as follows:

[0107] A, preparation of modified chitosan

[0108] To be sold by Jinan Haidebei Marine Bioengineering Co., Ltd. under the trade name of food and pharmaceutical grade chitosan, with a deacetylation degree of 70% and a molecular weight of 40×10 4 The chitosan of Da, dissolves 8min under the condition of stirring speed 280rpm in 1% acetic acid aqueous solution by weight, the solution that obtains is in the ultrasonic cleaning machine sold by trade name YD1008 ultrasonic cleaning machine by Changzhou Youda Ultrasonic Equipment Co., Ltd. In the process, ultrasonic treatment was carried out for 30 minutes under the conditions of ultrasonic frequency 22kHz and power 180W, and then the polyvinylidene fluoride ultrafiltration membrane sold by the American KENKER company under the trade name polyvinylidene fluoride membrane was used for classif...

Embodiment 3

[0118] Embodiment 3: prepare antibacterial modified chitosan foam agent

[0119] The implementation steps of this embodiment are as follows:

[0120] A, preparation of modified chitosan

[0121] To be sold by Jinan Haidebei Marine Bioengineering Co., Ltd. under the trade name of food and pharmaceutical grade chitosan, deacetylation degree 70%, molecular weight 50×10 4 The chitosan of Da, dissolves 12min under the condition of stirring speed 320rpm in 1% acetic acid aqueous solution by weight, the solution that obtains is in the ultrasonic cleaning machine sold by trade name YD1008 ultrasonic cleaning machine by Changzhou Youda Ultrasonic Equipment Co., Ltd. In the process, ultrasonic treatment was carried out for 50 minutes under the conditions of ultrasonic frequency 24kHz and power 220W, and then the polyvinylidene fluoride ultrafiltration membrane sold by the American KENKER company under the trade name polyvinylidene fluoride membrane was used for classification, and in t...

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Abstract

The invention relates to an antibacterial modified chitosan foaming agent and a preparation method thereof. The preparation method of the antibacterial modified chitosan foaming agent comprises the steps of preparing modified chitosan, extracting white tea, preparing a complex solution containing chitosan, preparing a corn protein complex solution and preparing an antibacterial modified chitosan foaming agent. The antibacterial modified chitosan foaming agent has antibacterial ability more than 99% on staphylococcus aureus, escherichia coli, streptococcus, candida albicans or pseudomonas aeruginosa and shows good bacteriostatic ability. The antibacterial modified chitosan foaming agent can be applied to treatment on bacterial vaginitis, colpomycosis and mixed vaginitis and can be widely applied.

Description

【Technical field】 [0001] The invention belongs to the technical field of medical drugs. More specifically, the present invention relates to a kind of antibacterial modified chitosan foam agent, also relate to the preparation method of described antibacterial modified chitosan foam agent 【Background technique】 [0002] Vaginitis is a common inflammation of female reproductive organs. Among married women, more than half of the population suffers from different degrees of vaginitis. Clinically, vaginitis can be divided into more than ten types, including bacterial vaginosis, trichomonas Vaginitis, candidal vaginitis, senile vaginitis, infantile vaginitis, candida vaginitis, viral HSV, HPv vaginitis, gonococcal vaginitis, desquamative vaginitis, non-specific vaginitis , tuberculous vaginitis, drug-induced vaginitis, radiation vaginitis, acute vaginal ulcer, allergic vaginitis, chronic vaginitis, burning insect vaginitis and mixed vaginitis, etc., are relatively common and serio...

Claims

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Application Information

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IPC IPC(8): A61K36/87A61K36/74A61K47/24A61K47/36A61K47/22A61K47/26A61K47/42A61K9/12A61P31/02A61K31/722
CPCY02A50/30
Inventor 汤瑞明耿在云
Owner JIANGSU RUIJING TECH DEV
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