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Silver-loaded meso-porous silicon-containing rinse-free antibacterial hand sanitizer and preparation method thereof

An antibacterial hand sanitizer and mesoporous silicon technology are applied in the direction of antibacterial drugs, antifungal agents, and pharmaceutical formulations, which can solve the problems of no moisturizing and moisturizing of the skin, single disinfection ingredients, and long-term antibacterial effects, and achieve simple equipment, The effect of simple process and cheap price

Inactive Publication Date: 2015-01-21
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese invention patent 00111388.7 discloses a dry hand sanitizer, but this product has a single disinfectant component, only contains chlorhexidine acetate, does not have a synergistic antibacterial effect and a relatively strong broad-spectrum antibacterial and bactericidal effect, and does not have a long-term effect Antibacterial effect; and there is no high-efficiency emollient ingredient, no moisturizing and moisturizing effect on the skin; Chinese invention patent 201210258471 discloses a nano-silver antibacterial and moisturizing lotion, but the silver in the lotion does not have a slow-release effect and cannot be long-lasting. antibacterial effect; Chen Meiwan et al [Chen Meiwan, Wen Xinguo, Peng Xinsheng, Chen Bao, Han Ke, Wu Chuanbin

Method used

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  • Silver-loaded meso-porous silicon-containing rinse-free antibacterial hand sanitizer and preparation method thereof
  • Silver-loaded meso-porous silicon-containing rinse-free antibacterial hand sanitizer and preparation method thereof
  • Silver-loaded meso-porous silicon-containing rinse-free antibacterial hand sanitizer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Soak 1g of mesoporous silicon in 50ml of silver nitrate solution (500mg / L), ultrasonically disperse it and shake it in a shaker at 37°C for 3 days, take it out and let it stand for 12 hours when it reaches the time point, pour off the supernatant, Wash 5 times with deionized water; freeze-dry for 48 hours to obtain silver-loaded mesoporous silicon; a kind of disposable antibacterial hand sanitizer containing silver-loaded mesoporous silicon, its raw material formula is as follows: silver-loaded mesoporous silicon 12mg, ethanol 50ml, vaseline 3g , stearic acid 1g, olive oil 1g, coconut oil 1g, castor oil 2g, lanolin 2g, lecithin 1g, lanolin acid 1g, Tween 80 0.5g, glyceryl stearate 1g, PEG-20 dehydration Phiitol isostearate 0.5g, Carbomer 940 1g, hydroxyethylcellulose 1g, hydroxypropylmethylcellulose 1g, triethanolamine 2g, citric acid 0.5g, tartaric acid 1g, glycerin 10ml, deionized water 20ml . Configured as 100ml disposable antibacterial hand sanitizer.

[0028] Dur...

Embodiment 2

[0030]Soak 1.2g of mesoporous silicon in 50ml of silver nitrate solution (500mg / L), ultrasonically disperse and shake in a shaker at 37°C for 2 days, take it out and let it stand for 24 hours when it reaches the time point, pour off the supernatant , washed 3 times with deionized water; freeze-dried for 24 hours to obtain silver-loaded mesoporous silicon; silver-loaded mesoporous silicon 10mg, isopropanol 50ml, polysiloxane 7g, cetyl alcohol 2g, vaseline 3g, sesame oil 1g, Almond oil 1g, peanut oil 1g, corn oil 0.5g, rice bran oil 1g, tea seed oil 0.5g, seabuckthorn oil 1.5g, avocado oil 1g, stone chestnut oil 1g, Tween 80 1g, macrogol glyceride 1g, Glyceryl stearate 0.2g, lecithin 1g, carbomer 940 1g, sodium carboxymethylcellulose 1g, triethanolamine 2g, glutaric acid 1g, maleic acid 1g, glutamic acid 1g, glycerin 10ml, deionized 15ml of water. Configured as 100ml disposable antibacterial hand sanitizer.

[0031] To prepare, silicone, cetyl alcohol, petrolatum, lecithin, se...

Embodiment 3

[0033] Soak 1.5g of mesoporous silicon in 50ml of silver nitrate solution (500mg / L), ultrasonically disperse and shake in a shaker at 37°C for 2 days, take it out and let it stand for 24 hours when it reaches the time point, pour off the supernatant , washed 3 times with deionized water; freeze-dried for 24 hours to obtain silver-loaded mesoporous silicon; silver-loaded mesoporous silicon 15mg, ethanol 30ml, castor oil 7g, cetyl alcohol 2g, vaseline 3g, polysiloxane 1g, rice bran Oil 20g, tea seed oil 10g, sea buckthorn oil 1g, avocado oil 1g, stone chestnut oil 1g, argan oil 4g, Tween 80 0.2g, glyceryl stearate 0.1, PEG-20 sorbitan isostearate Lipid 0.1, lecithin 1g, carbomer 940 1g, methylcellulose 1g, sodium carboxymethylcellulose 1g, triethanolamine 2g, malic acid 1g, succinic acid 0.5g, maleic acid 1g, glycerin 10ml, 15ml of ionized water. Configured as 100ml disposable antibacterial hand sanitizer.

[0034] For preparation, add castor oil, cetyl alcohol, lecithin, petr...

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Abstract

The invention discloses a silver-loaded meso-porous silicon-containing rinse-free antibacterial hand sanitizer and its preparation method. the preparation method comprises the following steps: adding a skin-protecting agent into an alcohol substance, heating, stirring and dissolving to form an alcoholic solution; immersing meso-porous silicon into an aqueous solution of silver nitrate, oscillating by a shaking table, taking out meso-porous silicon, and freeze-drying to obtain silver-loaded meso-porous silicon; adding a thickening agent, a surfactant and silver-loaded meso-porous silicon into deionized water so as to form an aqueous solution; and adding the aqueous solution into the alcoholic solution, adding a pH conditioning agent so as to prepare the meso-porous silicon-containing rinse-free antibacterial hand sanitizer. The preparation technology is simple, and cost is low. In addition, by utilizing structural features of meso-porous silicon to load silver, stability and slow-release effect of silver can be enhanced. The hand sanitizer has functions of broad-spectrum bacteriostasis and sterilization, has effects on various bacteria and fungi, and has long-acting antibacterial action. The hand sanitizer becomes a promising novel carrier material in the cosmetics industry.

Description

technical field [0001] The invention relates to a medical antibacterial hand sanitizer, in particular to a no-clean antibacterial hand sanitizer containing silver-loaded mesoporous silicon and a preparation method thereof. Background technique [0002] The hands of medical staff are an important medium for hospital infection and pathogen transmission. Hand scrubbing and disinfection of surgical personnel before operation plays a vital role in preventing nosocomial infection of surgical patients, as well as the resulting morbidity, death and related costs. There are many types of surgical hand sanitizers, among which the composition and content of skin disinfectants are different. Therefore, choosing the appropriate disinfectant is the key to the preoperative hand washing and disinfection of surgical personnel. [0003] Hand sanitizer needs to have the following three conditions: (1) quite strong broad-spectrum antibacterial and bactericidal effects, effective against a var...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/25A61K8/19A61K8/92A61K8/97A61Q19/10A61P31/04A61P31/10
Inventor 魏坤许为康
Owner SOUTH CHINA UNIV OF TECH
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