Hemostatic and anti-adhesion composite material of oxidized cellulose system and its preparation method

Abstract

The invention discloses a haemostatic anti-adhesion composite material of an oxycellulose system and a preparation method of the haemostatic anti-adhesion composite material. The composite material comprises anti-adhesion fiber filaments and haemostatic powder, wherein the anti-adhesion fiber filaments are interlaced mutually and prepared from organic polymer which has the molecular weight of 50000-500000 and the haemostatic powder is adhered to the external surfaces of the anti-adhesion fiber filaments and prepared from oxycellulose. By adhering the haemostatic powder of the oxycellulose of the composite material to the external surfaces of the mutually-interlaced anti-adhesion fiber filaments, the composite material disclosed by the invention can be rapidly changed into gel and adhered to the surface of a wound, diluted and adsorbed after being completely gelatinated, so a relatively good haemostatic effect is realized, the haemostatic speed is high, healing of the wound is not affected, and occurrence of postoperative adhesion is effectively reduced. Besides, cruor is locked in a fiber film formed by the mutually-interlaced anti-adhesion fiber filaments so that the wound is further protected.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a hemostatic and anti-adhesion composite material of an oxidized cellulose system and a preparation method thereof. Background technique [0002] After the peritoneum is damaged, rubbed, burned, dried, in contact with foreign bodies, or infected, the permeability of blood vessels increases, and inflammatory exudate and fibrin matrix are mediated by histamine, and the fibrin matrix can be dissolved by fibrin in the body process removal. Under normal circumstances, the activity of the fibrinolytic system is activated, fibrinolysis, and peritoneal mesothelialization. However, under abnormal conditions such as local ischemia caused by surgical trauma, the activity of the fibrinolytic system is inhibited, and fibrin forms bridges and eventually forms adhesions. Postoperative adhesion is one of the important medical problems that have not yet been solved in the field of ...

AI Technical Summary

Problems solved by technology

Our previous studies have shown that the combination of hemostatic agent and anti-adhesion material can effectively prevent the occurrence of postoperative active bleeding, but for the selection of the amount of hemostatic agent, how to better release it for different wounds and the remaining hemostatic agent in the anti-adhesion film after hemostasis is completed The problem of drug metabolism has not been solved

At the same time, we also combine the use of hemostatic gel and anti-adhesion materials to exert their respective effects, that is, to retain the mechanical strength of the anti-adhesion material and the hemostatic function of the hemostatic gel. The coagulation is locked in the material without inducing fibroblasts to adhere. At the same time, it does not affect the healing of mesothelial cells. Due to the limited adsorption capacity of the spongy body, this compound is only suitable for bleeding with a small amount of bleeding. For wounds where the vision of the wound is blurred and the bleeding point is not obvious, the wound care effect is not obvious.

[0004] Existing studies have shown that powdered hemostatic materials have better water absorption and faster hemostasis than gel and sponge hemostatic materials. However, the rapid hemostasis process of zeolite hemostatic powders will cause the local temperature of the wound to be too high , although starch and polysaccharide hemostatic powder greatly reduce the exothermic phenomenon in the dissolution process, there are also problems such as the spraying range is not easy to control, and the wound surface is difficult to clean after hemostasis. Especially for internal hemostasis, excessive hemostatic powder may induce excessive inflammatory reactions

The hemostatic materials in the prior art are used alone, and it is difficult to use them in combination with other membrane materials or gel materials. Generally, the hemostatic powder is sprayed and then covered with wound protection materials, which cannot avoid the disadvantages of using alone