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Polyvinyl alcohol/chitosan nano fiber film dressing containing nano silver and preparation thereof

A nanofiber membrane and chitosan nanotechnology, which can be used in fiber processing, medical science, textiles and papermaking, etc., can solve the problems of sponge dressings with small specific surface area, small porosity, wound cell adhesion and growth promotion, etc. , to achieve the effects of reducing shedding and agglomeration, improving stability, and simple preparation process

Active Publication Date: 2015-04-15
WUYI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dressing obtained by this method has good biocompatibility, water absorption and antibacterial properties, but this sponge dressing has a small specific surface area and small porosity, and has limited adhesion and growth promotion effects on wound cells

Method used

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  • Polyvinyl alcohol/chitosan nano fiber film dressing containing nano silver and preparation thereof
  • Polyvinyl alcohol/chitosan nano fiber film dressing containing nano silver and preparation thereof
  • Polyvinyl alcohol/chitosan nano fiber film dressing containing nano silver and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Weigh 8g of polyvinyl alcohol and dissolve it in a mixed solvent of 92g of water and ethanol (the mass ratio of water:ethanol is 8:15) to prepare 100g of polyvinyl alcohol solution with a mass fraction of 8%. Weigh 0.24g chitosan and dissolve in 7.76g 1% acetic acid solution to prepare 8g mass fraction of 3% chitosan solution. In a boiling water bath, add 0.6ml of silver nitrate solution with a concentration of 400g / L dropwise into polyvinylpyrrolidone / N,N-dimethylformamide solution (0.6g of polyvinylpyrrolidone dissolved in 5.4mL of N,N -dimethylformamide), continue to insulate and stir for 6h to make nano-silver sol. After the above-mentioned polyethanol and chitosan solution are mixed, the above-mentioned nano-silver sol is added dropwise while stirring, and after the dropwise addition is completed, the stirring is continued for 2 hours to form a spinning solution. The nanofiber membrane was obtained by spinning with an electrospinning device, with a voltage of 10kV...

Embodiment 2

[0041] The concentration of the polyvinyl alcohol solution is enlarged to 20%, the sealing and crosslinking time of the nanofibrous membrane is extended to 2h, and other reagents and dosages and process conditions are unchanged, and Example 1 is repeated to obtain a composite nanofiber membrane sample containing nanosilver A 2 .

Embodiment 3

[0043]Expand the concentration of chitosan solution to 10%, extend the sealing crosslinking time of nanofibrous membrane to 3h, other reagents and consumption and process conditions are constant, repeat embodiment 1, promptly make composite nanofibrous membrane sample containing nano-silver A 3 .

[0044] The above samples were tested for their dissolution stability by the following method:

[0045] Soak the cross-linked samples in the PBS buffer solution of pH = 7.4 (concentration of 0.1mol / L KH 2 PO 4 solution and 0.1mol / L Na 2 HPO 4 The solution was mixed at a volume ratio of 1:4) for 1 h, washed with distilled water after being taken out, and dried in a vacuum oven at 40°C for 24 h. Then, use a scanning electron microscope SEM (NoVaNaVo SEM430, FEI Company) to observe the microscopic morphology of the sample before and after soaking in PBS buffer solution.

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Abstract

The invention relates to a polyvinyl alcohol / chitosan nano fiber film dressing containing nano silver and preparation thereof. The nano fiber film dressing is prepared by the following steps: taking a mixture of polyvinyl alcohol and chitosan as the base material, then mixing nano silver into the polyvinyl alcohol / chitosan nano fiber film through an electrostatic spinning technology, and finally adding glutaraldehyde to crosslink the nano fiber film so as to obtain the target product. The obtained dressing has the characteristics that the preparation technology is simple; a wet environment can be achieved for promoting wound healing; and the dressing has an antiseptic function.

Description

technical field [0001] The invention relates to a biomedical textile, in particular to a nano silver-containing polyvinyl alcohol / chitosan nanofiber membrane dressing and its preparation. Background technique [0002] In 1962, British Professor Winter proposed the theory of moist therapy, and confirmed that compared with the dry wound environment exposed to the air, the moist environment formed after the application of moist and permeable medical dressings can promote the formation of epithelium and accelerate wound healing. heal. Since then, various wet dressings have emerged, and studies have shown that ideal medical dressings should have the following functions: ① absorb wound exudate, keep the wound moist, and prevent loss of body fluids and moisture; ② resist bacterial invasion and prevent infection ; ③ Promote the adhesion and growth of granulation and epithelial tissue. [0003] In order to maintain the wettability of the wound, many water-soluble polymer materials ...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/24A61L15/18D04H1/728D04H1/4382D06M13/123B22F9/24
Inventor 贾永堂黄钢董凤春曾显华吴翠
Owner WUYI UNIV
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