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Compound sulfadiazine suspension and preparation method thereof

A technology of sulfadiazine and a preparation method, which are applied in the field of compound sulfadiazine suspension, can solve the problems of low absorption rate of compound sulfadiazine suspension, greater physical stimulation of livestock, easy occurrence of crystalluria, etc. The effect of lasting drug utilization and maintaining antibacterial activity

Active Publication Date: 2015-07-29
SICHUAN CHENGKANG ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The traditional compound sulfadiazine suspension has low absorption rate, high acetylation rate, and low dissolution rate in urine, which is prone to crystalluria. Usually, this drug is injected twice a day, and the injection volume is large, which is very irritating to the livestock body.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The compound sulfadiazine suspension of the present invention is made of the following raw materials in parts by weight: 5 parts of sulfadiazine, 1 part of trimethoprim, 0.3 part of sodium hydroxide, 0.06 part of suspending agent A, 0.005 parts of agent B, 0.005 parts of surfactant and 100 parts of water for injection. The addition of trimethoprim to sulfadiazine enhanced the antibacterial effect nearly tenfold. in,

[0039] The suspending agent A is prepared by mixing xanthan gum, sorbitol with a concentration of 800ppm, sodium chloride and propylene glycol in a mass ratio of 80:2:0.03:50. Suspending agent A is made of xanthan gum, sorbitol with a concentration of 800-1500ppm, sodium chloride and propylene glycol according to a certain ratio. Inhibit the initial release rate of the drug, reduce the irritation of the livestock body, and add sorbitol and propylene glycol to work together to make the xanthan gum dissolve more fully and prevent the occurrence of caking. ...

Embodiment 2

[0061] The compound sulfadiazine suspension of the present invention is made of the following raw materials in parts by weight: 30 parts of sulfadiazine, 6 parts of trimethoprim, 1.5 parts of sodium hydroxide, 0.1 part of suspending agent A, 0.03 parts of agent B, 0.03 parts of surfactant and 300 parts of water for injection. The addition of trimethoprim to sulfadiazine enhanced the antibacterial effect nearly tenfold. in,

[0062] The suspending agent A is prepared by mixing xanthan gum, sorbitol with a concentration of 1500ppm, sodium chloride and propylene glycol in a mass ratio of 150:4:0.15:60. Suspending agent A is made of xanthan gum, sorbitol with a concentration of 800-1500ppm, sodium chloride and propylene glycol according to a certain ratio. Inhibit the initial release rate of the drug, reduce the irritation of the livestock body, add sorbitol and propylene glycol to make the xanthan gum dissolve more fully, and prevent the occurrence of caking. After adding sodiu...

Embodiment 3

[0084] The compound sulfadiazine suspension of the present invention is made of the following raw materials in parts by weight: 20 parts of sulfadiazine, 4 parts of trimethoprim, 1 part of sodium hydroxide, 0.08 parts of suspending agent A, 0.015 parts of agent B, 0.009 parts of surfactant and 200 parts of water for injection. The addition of trimethoprim to sulfadiazine enhanced the antibacterial effect nearly tenfold. in,

[0085] Described suspending agent A comprises that xanthan gum, concentration are 1200ppm sorbitol, sodium chloride and propylene glycol are made by mixing 100:3:0.1:55 by mass ratio; Suspending agent A adopts xanthan gum, concentration is 800-1500ppm sorbitol, sodium chloride and propylene glycol are made according to a certain ratio. Xanthan gum is an excellent carrier for controlled release of drugs. Stimulant, the addition of sorbitol and propylene glycol works together to dissolve xanthan gum more fully and prevent caking. After adding sodium chlor...

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Abstract

The invention discloses a compound sulfadiazine suspension. The compound sulfadiazine suspension comprises sulfadiazine, trimethoprim, sodium hydroxide, a suspending aid A, a suspending aid B, a surfactant and water for injection. The preparation method comprises steps as follows: sulfadiazine and trimethoprim are ground to 400-700 nm; trimethoprim is added to the suspending aid A; the mixture is dissolved, and a first dissolved solution is obtained; the water for injection is taken and heated to 45 DEG C, sulfadiazine and the suspending aid B are added, and a second dissolved solution is obtained; the rest water for injection is taken and heated to 30 DEG C-50 DEG C, sodium hydroxide is added and dissolved, the first dissolved solution is heated to 60 DEG C-65 DEG C, the second dissolved solution is heated to 40 DEG C-50 DEG C, then the first dissolved solution and the second dissolved solution are mixed, a third dissolved solution and the surfactant are added to a batching container and uniformly stirred, and a fourth dissolved solution is obtained; the prepared fourth dissolved solution is added to a high-speed homogenizer and sheared for 10-20 minutes, and filtrate is sterilized for 30 minutes at the temperature of 100-300 DEG C and under the pressure of 0.1-0.2 Mpa. The absorptivity is improved, the acetylation rate is decreased, and few crystals are formed in urine.

Description

technical field [0001] The present invention relates to sulfadiazine suspension preparation. More specifically, the present invention relates to a kind of compound sulfadiazine suspension that utilizes suspending agent to make. Background technique [0002] Sulfadiazine is an intermediate-acting sulfa drug. Molecular formula C 10 h 10 N 4 o 2 S, the molecular weight is 250.28, and its chemical name is: N-2-pyrimidinyl-4-aminobenzenesulfonamide. [0003] Compound sulfadiazine is a compound preparation of sulfadiazine and trimethoprim. The combination of the two has a synergistic antibacterial effect, and it is effective against non-enzyme-producing Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, Klebsiella Enterobacteriaceae such as Salmonella, Proteus, Morganella, Shigella, Neisseria gonorrhoeae, Neisseria meningitidis, and Haemophilus influenzae all have good antibacterial activity. It can enter the cerebrospinal fluid throu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/63A61K9/10A61K47/36A61K47/26A61K47/02A61K47/10A61K47/32A61K47/42A61K47/18A61K47/28A61P31/04A61K31/505
Inventor 胡进成王之丽杨军
Owner SICHUAN CHENGKANG ANIMAL PHARMA
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