Compound sulfadiazine suspension and preparation method thereof
A technology of sulfadiazine and a preparation method, which are applied in the field of compound sulfadiazine suspension, can solve the problems of low absorption rate of compound sulfadiazine suspension, greater physical stimulation of livestock, easy occurrence of crystalluria, etc. The effect of lasting drug utilization and maintaining antibacterial activity
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Embodiment 1
[0038] The compound sulfadiazine suspension of the present invention is made of the following raw materials in parts by weight: 5 parts of sulfadiazine, 1 part of trimethoprim, 0.3 part of sodium hydroxide, 0.06 part of suspending agent A, 0.005 parts of agent B, 0.005 parts of surfactant and 100 parts of water for injection. The addition of trimethoprim to sulfadiazine enhanced the antibacterial effect nearly tenfold. in,
[0039] The suspending agent A is prepared by mixing xanthan gum, sorbitol with a concentration of 800ppm, sodium chloride and propylene glycol in a mass ratio of 80:2:0.03:50. Suspending agent A is made of xanthan gum, sorbitol with a concentration of 800-1500ppm, sodium chloride and propylene glycol according to a certain ratio. Inhibit the initial release rate of the drug, reduce the irritation of the livestock body, and add sorbitol and propylene glycol to work together to make the xanthan gum dissolve more fully and prevent the occurrence of caking. ...
Embodiment 2
[0061] The compound sulfadiazine suspension of the present invention is made of the following raw materials in parts by weight: 30 parts of sulfadiazine, 6 parts of trimethoprim, 1.5 parts of sodium hydroxide, 0.1 part of suspending agent A, 0.03 parts of agent B, 0.03 parts of surfactant and 300 parts of water for injection. The addition of trimethoprim to sulfadiazine enhanced the antibacterial effect nearly tenfold. in,
[0062] The suspending agent A is prepared by mixing xanthan gum, sorbitol with a concentration of 1500ppm, sodium chloride and propylene glycol in a mass ratio of 150:4:0.15:60. Suspending agent A is made of xanthan gum, sorbitol with a concentration of 800-1500ppm, sodium chloride and propylene glycol according to a certain ratio. Inhibit the initial release rate of the drug, reduce the irritation of the livestock body, add sorbitol and propylene glycol to make the xanthan gum dissolve more fully, and prevent the occurrence of caking. After adding sodiu...
Embodiment 3
[0084] The compound sulfadiazine suspension of the present invention is made of the following raw materials in parts by weight: 20 parts of sulfadiazine, 4 parts of trimethoprim, 1 part of sodium hydroxide, 0.08 parts of suspending agent A, 0.015 parts of agent B, 0.009 parts of surfactant and 200 parts of water for injection. The addition of trimethoprim to sulfadiazine enhanced the antibacterial effect nearly tenfold. in,
[0085] Described suspending agent A comprises that xanthan gum, concentration are 1200ppm sorbitol, sodium chloride and propylene glycol are made by mixing 100:3:0.1:55 by mass ratio; Suspending agent A adopts xanthan gum, concentration is 800-1500ppm sorbitol, sodium chloride and propylene glycol are made according to a certain ratio. Xanthan gum is an excellent carrier for controlled release of drugs. Stimulant, the addition of sorbitol and propylene glycol works together to dissolve xanthan gum more fully and prevent caking. After adding sodium chlor...
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