Bioactive porous titanium medical implant material and preparation method

Abstract

The invention discloses a bioactive porous titanium medical implant material and a preparation method and belongs to the technical field of biomedical materials. The material comprises a base layer and a surface layer; the base layer is made of porous titanium; the surface layer includes a dense titanium oxide layer, a titanium oxide gel mediate layer and a calcium phosphate external layer. The method includes porous titanium blank preparation, blank sintering and surface chemical and electrochemical treatment. The material prepared by the method has the advantages of a three-dimensional communicated porous structure with adjustable porosity and pore size, the mechanical strength matches with the body's natural bones, the bioactivity can be improved through the bioactive layer with the three layered surface structure, the porous material with a gradient pore structure can be prepared through combination of organic foam with different pore sizes, and the material is particularly adaptive to serving as a bone defect repair or replace material of the human body load-bearing portion.

Description

technical field [0001] The invention relates to a preparation method of bioactive porous titanium medical implant material, which belongs to the field of biomedical materials. technical background [0002] The excellent mechanical properties of metal materials make them widely used in medical devices, especially orthopedic materials and devices. Titanium and titanium alloys are the most successful medical metal materials in clinical application so far. Their good biocompatibility, high mechanical strength and corrosion resistance make them a suitable choice for damaged hard tissues in the load-bearing parts of the human body, such as bones, joints, and teeth. materials of choice for replacement or repair. However, the intrinsic biological inertness of titanium and titanium alloys makes it difficult to form effective osseointegration with surrounding bone tissue, which often leads to implant loosening and chronic inflammation, eventually leading to implant failure. In addit...

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Problems solved by technology

However, the hydroxyapatite powder in the high-temperature and high-speed plasma jet is easy to melt, phase change or even decompose, which leads to the complexity of the composition of the hydroxyapatite coating, and the thermal expansion coefficient mismatch with the base metal causes the coating Easy to peel off in liquid etc.

Furthermore, the linear process of plasma spraying precludes its application on implants with irregular shapes and porous structures

In recent years, the normal temperature liquid phase nonlinear coating preparation technology has been developed rapidly. For example, the apatite coating prepared by the biomimetic mineralization deposition method is closer to the inorganic matter of human bone, the process is simple, the cost is low, and the coating composition However, there are problems such as slow coating growth rate, difficulty in controlling coating thickness and uniformity, poor adhesion between coating and substrate, etc.

In contrast, the electrochemical deposition method is a convenient and economical method, the reaction is mostly carried out at a lower temperature, the uniform thickness of the coating is adjustable, and the repeatability is good, but the prior art is applied to the coating of the porous metal surface The preparation still needs to solve the problem of the uniformity of coating deposition on the surface of the internal pores, and there is no relevant record of preparing a multi-layer structure bioactivation modified layer on the surface of porous metal

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