Bioactive porous titanium medical implant material and preparation method

An implant material and bioactive technology, which is applied in the field of preparation of bioactive porous titanium medical implant materials, can solve the problem of poor bonding between the coating and the substrate, slow growth of the coating, and complex composition of the hydroxyapatite coating, etc. question

Active Publication Date: 2015-09-23
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the hydroxyapatite powder in the high-temperature and high-speed plasma jet is easy to melt, phase change or even decompose, which leads to the complexity of the composition of the hydroxyapatite coating, and the thermal expansion coefficient mismatch with the base metal causes the coating Easy to peel off in liquid etc.
Furthermore, the linear process of plasma spraying precludes its application on implants with irregular shapes and porous structures
In recent years, the normal temperature liquid phase nonlinear coating preparation technology has been developed rapidly. For example, the apatite coating prepared by the biomimetic mineralization deposition method is closer to the inorganic matter of human bone, the process is simple, the cost is l

Method used

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  • Bioactive porous titanium medical implant material and preparation method
  • Bioactive porous titanium medical implant material and preparation method
  • Bioactive porous titanium medical implant material and preparation method

Examples

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Effect test

Embodiment 1

[0064] Add 10 g of PVA into a beaker containing 150 mL of deionized water, heat and stir it evenly; then add 50 mL of absolute ethanol into the beaker, and mix evenly. Weigh a certain amount of commercially pure titanium powder (with a particle size of 38-45 microns) into the PVA solution to prepare three titanium slurries with a solid-liquid ratio of 8g / 10mL, 6g / 10mL, and 3g / 10mL. Use 40 PPI polyurethane foam (20×20×32 mm 3) impregnated into titanium slurry, after the foam pores are filled with titanium slurry, put it into a high-speed centrifuge to remove excess slurry, and then put it in a vacuum drying oven to dry. Repeat the above process for a total of 3 times in the titanium slurry with a solid-to-liquid ratio of 6g / 10mL, and repeat the above-mentioned process for a total of 3 times in a titanium slurry with a solid-to-liquid ratio of 3g / 10mL. The green body that paddles 7 times. Sinter the green body obtained in a vacuum sintering furnace, raise the temperature to 20...

Embodiment 2

[0067] Add 10 g of PVA into a beaker containing 150 mL of deionized water, heat and stir it evenly; then add 50 mL of absolute ethanol into the beaker, and mix evenly. A certain amount of commercially pure titanium powder (38-45 microns in particle size) was weighed into the PVA solution to prepare two titanium slurries with a solid-liquid ratio of 8g / 10mL and 6g / 10mL. Use 40 PPI polyurethane foam (20×20×32 mm 3 ) impregnated into titanium slurry, after the foam pores are filled with titanium slurry, put it into a high-speed centrifuge to remove excess slurry, and then put it in a vacuum drying oven to dry. The above process was repeated for a total of 3 times, and the above process was performed once in a titanium slurry with a solid-to-liquid ratio of 6g / 10mL, to obtain a green body with a total of 4 paddles. Sinter the green body obtained in a vacuum sintering furnace, raise the temperature to 200°C at 5°C / min, raise the temperature to 600°C at 2°C / min, and then hold it fo...

Embodiment 3

[0070] Add 10 g of PVA into a beaker containing 150 mL of deionized water, heat and stir it evenly; then add 50 mL of absolute ethanol into the beaker, and mix evenly. Weigh a certain amount of commercially pure titanium powder (with a particle size of 38-45 microns) into the PVA solution to prepare three titanium slurries with a solid-liquid ratio of 8g / 10mL, 6g / 10mL, and 3g / 10mL. Use 20 PPI polyurethane foam (20×20×32 mm 3 ) impregnated into titanium slurry, after the foam pores are filled with titanium slurry, put it into a high-speed centrifuge to remove excess slurry, and then put it in a vacuum drying oven to dry. Repeat the above process for a total of 3 times in the titanium slurry with a solid-to-liquid ratio of 6g / 10mL, and repeat the above-mentioned process for a total of 3 times in a titanium slurry with a solid-to-liquid ratio of 3g / 10mL. The green body that paddles 7 times. Sinter the green body obtained in a vacuum sintering furnace, raise the temperature to 2...

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Abstract

The invention discloses a bioactive porous titanium medical implant material and a preparation method and belongs to the technical field of biomedical materials. The material comprises a base layer and a surface layer; the base layer is made of porous titanium; the surface layer includes a dense titanium oxide layer, a titanium oxide gel mediate layer and a calcium phosphate external layer. The method includes porous titanium blank preparation, blank sintering and surface chemical and electrochemical treatment. The material prepared by the method has the advantages of a three-dimensional communicated porous structure with adjustable porosity and pore size, the mechanical strength matches with the body's natural bones, the bioactivity can be improved through the bioactive layer with the three layered surface structure, the porous material with a gradient pore structure can be prepared through combination of organic foam with different pore sizes, and the material is particularly adaptive to serving as a bone defect repair or replace material of the human body load-bearing portion.

Description

technical field [0001] The invention relates to a preparation method of bioactive porous titanium medical implant material, which belongs to the field of biomedical materials. technical background [0002] The excellent mechanical properties of metal materials make them widely used in medical devices, especially orthopedic materials and devices. Titanium and titanium alloys are the most successful medical metal materials in clinical application so far. Their good biocompatibility, high mechanical strength and corrosion resistance make them a suitable choice for damaged hard tissues in the load-bearing parts of the human body, such as bones, joints, and teeth. materials of choice for replacement or repair. However, the intrinsic biological inertness of titanium and titanium alloys makes it difficult to form effective osseointegration with surrounding bone tissue, which often leads to implant loosening and chronic inflammation, eventually leading to implant failure. In addit...

Claims

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Application Information

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IPC IPC(8): A61L27/06A61L27/32A61L27/56
Inventor 朱向东王春利陈宏杰肖占文张凯樊渝江张兴栋
Owner SICHUAN UNIV
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