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Hydrophilicity modification method of hydroxyapatite single-crystal nanorod

A hydroxyapatite, single crystal nanotechnology, applied in the direction of single crystal growth, single crystal growth, chemical instruments and methods, etc., can solve problems such as hydrophilicity limitation, achieve stable product quality, easy process amplification, and good application Foreground effect

Inactive Publication Date: 2015-12-09
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to obtain uniform nano-scale products of hydroxyapatite, the hydrophobic oleic acid reaction system is usually used to control the synthesis, and the surface of the obtained product is a hydrophobic surface, but its hydrophilicity is limited to a certain extent, so that it can be used in the biological field limitations

Method used

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  • Hydrophilicity modification method of hydroxyapatite single-crystal nanorod

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Experimental program
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Effect test

Embodiment 1

[0023] In a 100mL flask, add the above-mentioned 800mg hydrophobic hydroxyapatite nanorods, 200mg riboflavin sodium phosphate, and 50mL acetone solution, and reflux at 60°C for 6-8h to obtain sample A; The functional group (-OH) and the chain transfer agent CTA synthesize a new chain transfer agent, the reaction conditions: 600mg product A and 108mg S-isocyanate-N-ethyl-N'-phenyldithiocarbamate (CTA ) using N,N'-dicyclohexylcarbodiimide (DCC, 1.00g) as a dehydrating agent, 4-dimethylaminopyridine (DMAP, 200mg) as a catalyst to form a new chain transfer agent, and react at room temperature for 18-24h For sample B. Finally, 100mg of sample B was used as a new chain transfer agent, 12mg of azobisisobutyronitrile (AIBN) was used as a chain initiator, 1.00g of hydrophilic polymer polyethylene glycol methacrylate (PEGMA) was used as a monomer, and tetrahydrofuran was used as a monomer. solvent, reacted for 24h under nitrogen environment, and collected samples.

[0024] After modif...

Embodiment 2

[0026] In a 100mL flask, add 800mg hydrophobic hydroxyapatite nanorods, 200mg riboflavin sodium phosphate, 50mL acetone solution, and reflux at 60°C for 6-8h to obtain sample A; Functional group (-OH) and chain transfer agent CTA to synthesize a new chain transfer agent, reaction conditions: 600mg product A and 108mg S-isocyanate-N-ethyl-N'-phenyldithiocarbamate (CTA) Use N,N'-dicyclohexylcarbodiimide (DCC, 1.00g) as a dehydrating agent, and 4-dimethylaminopyridine (DMAP, 200mg) as a catalyst to form a new chain transfer agent. The reaction at room temperature for 18-24h is recorded as Sample B. Finally, 100mg of sample B was used as a new chain transfer agent, 12mg of azobisisobutyronitrile (AIBN) was used as a chain initiator, 2.00g of hydrophilic polymer polyethylene glycol methacrylate (PEGMA) was used as a monomer, and tetrahydrofuran was used as a monomer. solvent, reacted for 24h under nitrogen environment, and collected samples.

Embodiment 3

[0028] In a 100mL flask, add 800mg hydrophobic hydroxyapatite nanorods, 200mg riboflavin sodium phosphate, 50mL acetone solution, and reflux at 60°C for 6-8h to obtain sample A; Functional group (-OH) and chain transfer agent CTA to synthesize a new chain transfer agent, reaction conditions: 600mg product A and 108mg S-isocyanate-N-ethyl-N'-phenyldithiocarbamate (CTA) Use N,N'-dicyclohexylcarbodiimide (DCC, 1.00g) as a dehydrating agent, and 4-dimethylaminopyridine (DMAP, 200mg) as a catalyst to form a new chain transfer agent. The reaction at room temperature for 18-24h is recorded as Sample B. Finally, 100mg of sample B was used as a new chain transfer agent, 12mg of azobisisobutyronitrile (AIBN) was used as a chain initiator, 1.00g of hydrophilic polymer phospholipid was used as a monomer, tetrahydrofuran was used as a solvent, and the reaction was carried out under nitrogen for 24 hours to collect samples .

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Abstract

The invention discloses a hydrophilicity modification method of a hydroxyapatite single-crystal nanorod. The hydrophilicity modification method comprises the following steps: firstly, synthesizing hydroxyapatite nanocrystalline with the surface modified by oleic acid; carrying out reflux reaction on the hydroxyapatite nanocrystalline with the surface modified by oleic acid and adenosine 5'-monophosphate sodium salt or riboflavin sodium phosphate, according to the mass ratio of 4: 1, in an acetone solvent for surface ligand exchange, so as to prepare a sample A; reacting the sample A with S-isocyanic acid-N-ethyl-N'-phenyl dithiocarbamate, so as to obtain a hydroxyapatite nanocrystalline sample B with the surface modified by a chain transfer agent; carrying out reversible addition-fragmentation chain transfer polymerization reaction on the sample B and a hydrophilic polymer. The hydrophilic nano-hydroxyapatite prepared through the method can be used in medicine carrying and substituting and cell imaging, can be used as an inorganic raw material for preparing degradable biomedical materials, such as artificial bones and bone cement, and has a good application prospect in relevant fields, such as biological materials and tissue engineering.

Description

technical field [0001] The invention relates to a method for modifying the hydrophilicity of hydroxyapatite single crystal nanorods. Background technique [0002] With the development of life sciences, people hope to obtain rich and detailed intuitive information about tissues, cells, etc., prompting the rapid development of various imaging technologies. Among them, the hydrophilicity of materials is very important, which affects the absorption of materials by cells and animals, thus restricting the application of materials. [0003] Hydroxyapatite (Ca 10 (OH) 2 (PO 4 ) 6 ,HAp) has excellent biocompatibility, osteoinductivity, non-immunogenicity, degradability and other properties, and is widely used in tissue engineering, drug and gene delivery and other biological fields. At the same time, hydroxyapatite is also a good ion-doped matrix material, which is often endowed with new physical and chemical properties by impurity ions. In order to obtain uniform nano-scale pr...

Claims

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Application Information

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IPC IPC(8): C30B29/60C30B7/00C30B33/00
Inventor 衡春宁郑晓燕张小勇范代娣惠俊峰
Owner NORTHWEST UNIV
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