Method for rapidly screening 40 prohibited antibiotics in cosmetics

A technology for antibiotics and cosmetics, applied in the direction of measuring devices, material analysis through electromagnetic means, instruments, etc., can solve problems such as skin irritation, health hazards, microbial resistance, etc., to improve detection efficiency, reduce detection costs, and ensure accuracy sexual effect
CN105181784AActive Publication Date: 2015-12-23CHINESE ACAD OF INSPECTION & QUARANTINE
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
CHINESE ACAD OF INSPECTION & QUARANTINE
Publication Date
2015-12-23

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Abstract

The invention discloses a method for rapidly screening 40 prohibited antibiotics in cosmetics. The method comprises the following steps: (1) manufacturing an in-situ spray ionization device: producing a borosilicate glass capillary and assembling an in-situ spray ionization device; (2) ion mobility spectrometry detection: dipping a metal micro electrode into a cosmetic sample, then inserting the metal micro electrode into a borosilicate glass capillary, which is filled with methanol in advance, placing the capillary on the front end of the electrospray ionization (ESI) injection port of an ion mobility spectrometry instrument, setting the parameters of the ion mobility spectrometry instrument, ionizing the sample, separating the ionized sample in a drift tube, detecting the sample by a Faraday cup detector to obtain a corresponding experiment map. If the sample detected by the ion mobility spectrometry contains prohibited antibiotics, the sample can be further detected by high performance liquid chromatography-mass spectrum (HPLC-MS) or mass spectrum. The provided method is accurate and reliable, on the basis that the detected data is precise, the detection cost is largely reduced, and the detection efficiency is improved.
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Description

technical field

[0001] The invention relates to a detection method, in particular to a method for quickly screening 40 prohibited antibiotics in cosmetics by ion mobility spectrometry. Background technique

[0002] Antibiotics are a class of prescription drugs. Long-term use can cause adverse reactions such as contact dermatitis, manifested as erythema, edema, erosion, desquamation, exudation, itching, burning, etc. my country's "Hygienic Standards for Cosmetics" (2007 edition) stipulates that antibiotic ingredients are prohibited ingredients in cosmetics, and the European Union also stipulates that antibiotics must not be added to cosmetics. Therefore, adding antibiotics to cosmetics is a violation.

[0003] Quinolone antibiotics, nitrofuran antibiotics, chloramphenicol antibiotics, and nitroimidazole antibiotics are all four types of antibiotics that are easily added to cosmetics. Adding antibiotic ingredients to cosmetics can significantly improve their mite and acne rem...

Claims

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