Method for rapidly screening 40 prohibited antibiotics in cosmetics

A technology for antibiotics and cosmetics, applied in the direction of measuring devices, material analysis through electromagnetic means, instruments, etc., can solve problems such as skin irritation, health hazards, microbial resistance, etc., to improve detection efficiency, reduce detection costs, and ensure accuracy sexual effect

Active Publication Date: 2015-12-23
CHINESE ACAD OF INSPECTION & QUARANTINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Quinolone antibiotics, nitrofuran antibiotics, chloramphenicol antibiotics, and nitroimidazole antibiotics are all four types of antibiotics that are easily added to cosmetics. Adding antibiotic ingredients to cosmetics can significantly improve their mite and acne removal effects. It also has a certain curative effect on foll

Method used

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  • Method for rapidly screening 40 prohibited antibiotics in cosmetics
  • Method for rapidly screening 40 prohibited antibiotics in cosmetics
  • Method for rapidly screening 40 prohibited antibiotics in cosmetics

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Embodiment 1

[0047] 1. Instruments and devices

[0048] Ion mobility spectrometer host (USA EXCELLIMS company, model GA2100, use tryptophan and citric acid to calibrate the instrument in positive and negative ion modes before use), including ion gate controller, air filter device, high-resolution ion mobility analyzer , Faraday cup detector, instrument control and data processing system; standard wall borosilicate glass blank (outer diameter 1.5mm, inner diameter 0.86mm); microelectrode drawing instrument (SUTTER Company, USA, model P-1000).

[0049] 2. Reagents and materials

[0050]Methanol, acetonitrile (U.S. Fisher Company) and formic acid (U.S. Sigma-Aldrich Company) are chromatographically pure; tryptophan and citric acid (U.S. Sigma-Aldrich, prepared with methanol to 10 μg / mL for instrument calibration); 40 banned antibiotics (nalidixic acid, flumequine, danoxacin, mabofloxacin, lomefloxacin, sparfloxacin, pazufloxacin, nafloxacin, ciprofloxacin, moxifloxacin, ofloxacin Star, difl...

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PUM

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Abstract

The invention discloses a method for rapidly screening 40 prohibited antibiotics in cosmetics. The method comprises the following steps: (1) manufacturing an in-situ spray ionization device: producing a borosilicate glass capillary and assembling an in-situ spray ionization device; (2) ion mobility spectrometry detection: dipping a metal micro electrode into a cosmetic sample, then inserting the metal micro electrode into a borosilicate glass capillary, which is filled with methanol in advance, placing the capillary on the front end of the electrospray ionization (ESI) injection port of an ion mobility spectrometry instrument, setting the parameters of the ion mobility spectrometry instrument, ionizing the sample, separating the ionized sample in a drift tube, detecting the sample by a Faraday cup detector to obtain a corresponding experiment map. If the sample detected by the ion mobility spectrometry contains prohibited antibiotics, the sample can be further detected by high performance liquid chromatography-mass spectrum (HPLC-MS) or mass spectrum. The provided method is accurate and reliable, on the basis that the detected data is precise, the detection cost is largely reduced, and the detection efficiency is improved.

Description

technical field [0001] The invention relates to a detection method, in particular to a method for quickly screening 40 prohibited antibiotics in cosmetics by ion mobility spectrometry. Background technique [0002] Antibiotics are a class of prescription drugs. Long-term use can cause adverse reactions such as contact dermatitis, manifested as erythema, edema, erosion, desquamation, exudation, itching, burning, etc. my country's "Hygienic Standards for Cosmetics" (2007 edition) stipulates that antibiotic ingredients are prohibited ingredients in cosmetics, and the European Union also stipulates that antibiotics must not be added to cosmetics. Therefore, adding antibiotics to cosmetics is a violation. [0003] Quinolone antibiotics, nitrofuran antibiotics, chloramphenicol antibiotics, and nitroimidazole antibiotics are all four types of antibiotics that are easily added to cosmetics. Adding antibiotic ingredients to cosmetics can significantly improve their mite and acne rem...

Claims

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Application Information

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IPC IPC(8): G01N27/64
Inventor 马强孟宪双白桦郭项雨
Owner CHINESE ACAD OF INSPECTION & QUARANTINE
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