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A kind of composite porous sponge material and preparation method thereof

A porous and sponge technology, applied in medical science, prosthesis, tissue regeneration, etc., can solve the problems of easy deformation, weak strength, and difficulty, and achieve the effect of easy absorption and contraction, promotion of cell reproduction, and high strength

Active Publication Date: 2018-05-29
WUHAN HUAYI TONGXIN BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the other hand, collagen, hyaluronic acid, proteoglycan, glucosamine, chondroitin sulfate and other bioabsorbable natural polymers have good affinity, and it is easy to produce porous sponge materials with high porosity, but the processing performance is relatively poor. The strength is very weak, it is difficult to produce the shape we want, and it is easy to deform under pressure during culture or after transplantation in vivo

Method used

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  • A kind of composite porous sponge material and preparation method thereof
  • A kind of composite porous sponge material and preparation method thereof
  • A kind of composite porous sponge material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The sodium chloride crystalline particles are separated by sieving with a 170-mesh sieve and a 100-mesh sieve to obtain particles with a diameter of about 90 μm to 150 μm. On the other hand, 1 g of PLLA was dissolved in 5 mL of chloroform to prepare a synthetic polymer solution. Put the chloroform solution in which PLLA is dissolved into a glass test tube, add 9 g of sodium chloride crystal particles (9 times the amount of PLLA) of 90 μm to 150 μm and mix evenly. Then, the uniformly mixed PLLA-NaCl-chloroform was filled into a mold (made of polytetrachloroethylene). Use this mold to make a hollow porous sponge structure composed of bioabsorbable synthetic polymers. The mixture is tightly filled into the mold gap, dried in the atmosphere for 3-4 days, and then vacuum dried for another day. After drying, remove the solid PLLA-sodium chloride from the casting mold, and soak in distilled water to wash out the sodium chloride. Distilled water was exchanged every 2 hours f...

Embodiment 2

[0048] The sodium chloride crystalline particles are separated by sieving with a 100-mesh sieve and a 60-mesh sieve to obtain particles with a diameter of about 150 μm to 250 μm. On the other hand, 1 g of PLLA was dissolved in 5 mL of chloroform to prepare a synthetic polymer solution. Put the chloroform solution in which PLLA was dissolved into a glass test tube, add 9 g of sodium chloride crystal particles (9 times the amount of PLLA) with a particle size of 150 μm to 250 μm, and mix evenly. Then, the uniformly mixed PLLA-NaCl-chloroform was filled into a mold (made of polytetrachloroethylene). Use this mold to make a hollow porous sponge structure composed of bioabsorbable synthetic polymers. The mixture is tightly filled into the mold gap, dried in the atmosphere for 3-4 days, and then vacuum dried for another day. After drying, remove the solid PLLA-sodium chloride from the casting mold, and soak in distilled water to wash out the sodium chloride. Distilled water was e...

Embodiment 3

[0051] Bone morphogenetic protein BMP can induce mesenchymal cells to differentiate into bone, cartilage, ligament, tendon and nerve tissue to promote cartilage joint repair. Regulate calcium and phosphorus metabolism to deposit bone calcium, stimulate osteoblast proliferation, inhibit inflammatory infiltration of joint inflammation and postoperative swelling and pain after fracture. This example tries to add BMP-2 to make a composite material, and the growth factor is not limited to BMP.

[0052] The sodium chloride crystalline particles are separated by sieving with a 170-mesh sieve and a 100-mesh sieve to obtain particles with a diameter of about 90 μm to 150 μm. On the other hand, 1 g of PLLA was dissolved in 5 mL of chloroform to prepare a synthetic polymer solution. Put the chloroform solution in which PLLA is dissolved into a glass test tube, add 9 g of sodium chloride crystal particles (9 times the amount of PLLA) of 90 μm to 150 μm and mix evenly. Then, the uniforml...

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Abstract

The invention provides a composite porous sponge material, which is refined by mixing bioabsorbable synthetic macromolecules of a peripheral skeleton and a natural polymer porous substance which is cross-linked and filled inside and is higher in porosity compared with the peripheral skeleton, wherein the bioabsorbable synthetic macromolecules contain hollow parts, and the hollow parts are filled with one or more of bioabsorbable natural polymer porous materials, cell growth factors and cell differentiation control factors. Specifically, the preparation method comprises the following steps: preparing a bioabsorbable synthetic polymer porous sponge material; preparing and filling a bioabsorbable natural polymer solution; and freeze-drying the synthetic polymer porous sponge material which is filled with the natural polymer solution, and bridging, so that the composite porous sponge material is obtained. The composite material, after being freeze-dried, can form a structure that orifices are communicated in the center, so that biological cells are easy to spread and enter the orifices; and the cells, in a high-affinity environment, can rapidly adhere to walls, so that the cells can rapidly adapt to the environment to absorb nutrition and the proliferation of various cell factors can be promoted.

Description

technical field [0001] The present invention relates to the use of polymer composite materials to guide the regeneration of human organs, such as repairing the regeneration of articular cartilage and bone regeneration, specifically composite porous sponge material and its preparation method, aiming at cultivating the patient's own cells in the porous sponge material, After a period of in vitro culture, the organism is transplanted. Background technique [0002] Due to traffic accidents, sports, production labor, getting older, diseases and other reasons, organisms are often damaged and unfortunately lose tissues such as cartilage and bone. Articular cartilage injuries are also common in orthopedics departments in hospitals, because there are no blood vessels in cartilage tissue, and chondrocytes Lack of migratory ability in an avascular environment. It is difficult to regenerate cartilage after injury. In the field of orthopedic surgery, how to repair or treat traumatic and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/56A61L27/54A61L27/38A61L27/24A61L27/20A61L27/18
CPCA61L27/18A61L27/20A61L27/24A61L27/38A61L27/54A61L27/56A61L2300/414A61L2430/06C08L67/04C08L5/08
Inventor 何小明
Owner WUHAN HUAYI TONGXIN BIOLOGICAL TECH CO LTD
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