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A comprehensive functional toothpaste containing nanodiamondene

A nanodiamondene and functional technology, which is applied in the field of oral hygiene and health care, can solve the problems of uneven powder particle size, reduced drug treatment effect, and reduced original efficacy of drug ingredients, and achieves increased surface adsorption capacity and high specific surface area. , the effect of strong adsorption capacity

Active Publication Date: 2018-05-18
ZHENGZHOU ARTIFICIAL DIAMOND & PROD ENG TECH RES CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] 1. In the toothpaste containing pharmaceutical ingredients, due to the uneven particle size of the powder, it is difficult to effectively and evenly mix with other components in the toothpaste. As a result, it is difficult to fully contact with the oral tissue and reduce the actual efficacy
[0006] 2. In the toothpaste formula containing medicine, although it can be mixed evenly in the toothpaste formula, this kind of mixing is only physical mixing. In practice, it is taken away from the oral environment with the process of rapid tooth brushing and mouthwash. The short retention time in the medium can not effectively release the drug effect
These medicinal ingredients will produce a certain degree of physical and chemical reactions after being mixed with other ingredients of the toothpaste, and the original efficacy of the medicinal ingredients will be reduced due to these reactions, thereby reducing the therapeutic effect of the medicine as a whole

Method used

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  • A comprehensive functional toothpaste containing nanodiamondene
  • A comprehensive functional toothpaste containing nanodiamondene
  • A comprehensive functional toothpaste containing nanodiamondene

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1 Preparation of nanodiamondene

[0025] Prepare nanodiamondene by the following method:

[0026] (1) Preliminary crushing: Send the diamond raw material into the ball mill shaping barrel to crush and sieve out the particles above 70 mesh. The crushing time is 1-5 hours. The coarse material below 70 mesh is returned to the ball mill shaping barrel for re-crushing; The sieve machine sieves out fine materials with a mesh size of 800 mesh or more, and the vibrating time is 30 minutes to 2 hours, and the fine materials are repeatedly sieved more than once;

[0027] (2) Re-crushing: The fine material above 800 mesh screened is transported to the air flow crusher, the fine material is crushed by high-pressure airflow, and the fine powder above 8000 mesh is screened out, and the sieved residue is returned to the air flow crusher for re-crushing ;

[0028] (3) Pickling: First, put the fine powder above 8000 mesh in the mixture of concentrated sulfuric acid and conc...

Embodiment 2

[0033] A comprehensive functional toothpaste containing nano-diamantene, prepared from the following raw materials in weight percentage: 0.7% nano-diamantene (without surface functionalization treatment), 40% abrasive, 0.15% paraben %, 2% hydroxyethyl cellulose, 1.2% sodium carboxymethyl cellulose, 1.2% strontium chloride, 3.0% naringin, 0.04% compound chlorhexidine, 3.5% thickener, 0.05% sweetener , preservative 0.08%, wetting agent 22%, sodium lauryl sulfate 2.5%, and the balance is deionized water.

[0034] The above-mentioned comprehensive functional toothpaste containing nanodiamondene is prepared according to the following process:

[0035](1) Use deionized water to fully mix nanodiamondene, strontium chloride, naringin, compound chlorhexidine and some thickeners in a shaker to prevent precipitation;

[0036] (2) Dissolve friction agent, paraben, sodium carboxymethyl cellulose, sweetener and hydroxyethyl cellulose in the remaining deionized water, then add wetting agent...

Embodiment 3

[0039] The difference between Example 3 and Example 2 lies in that: Example 3 uses nanodiamondene treated with surface functionalization to prepare a comprehensive functional toothpaste. Specifically: a comprehensive functional toothpaste containing nanodiamondene, which is prepared from the following raw materials in weight percentage: 0.7% nanodiamondene after surface functionalization treatment, 40% abrasive agent, 0.15% paraben %, 2% hydroxyethyl cellulose, 1.2% sodium carboxymethyl cellulose, 1.2% strontium chloride, 3.0% naringin, 0.04% compound chlorhexidine, 3.5% thickener, 0.05% sweetener , preservative 0.08%, wetting agent 22%, sodium lauryl sulfate 2.5%, and the balance is deionized water.

[0040] The nano-diamantene is treated with surface functionalization, and the treatment process is as follows: the nano-diamantene is placed in concentrated HNO with a mass ratio of 1:2 3 / Concentrated H 2 SO 4 In the mixed solution, heat and reflux at 90°C for 24 hours and ...

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Abstract

The invention discloses a comprehensive functional toothpaste containing nano-diamondene, which belongs to the field of oral hygiene and health care. The toothpaste is prepared from the following raw materials in weight percentage: 0.5%~1% of nano-diamondene, 15%~ 50%, paraben 0.1%~0.3%, hydroxyethyl cellulose 1.5%~2.5%, carboxymethyl cellulose sodium 1%~1.5%, strontium chloride 0.6%~1.5%, pomelo peel Glycoside 1.0%~3.0%, compound chlorhexidine 0.01%~0.05%, thickener 2%~5%, sweetener 0.03%~0.1%, preservative 0.05%~0.1%, wetting agent 20%~25% %, sodium lauryl sulfate 1%~4%, and the balance is deionized water. Nano diamondene is added to the comprehensive functional toothpaste provided by the present invention, the comprehensive functional toothpaste can simultaneously treat various oral problems, the effect is obvious and the duration is long; the comprehensive functional toothpaste can replace other oral diseases to a certain extent The method reduces the maintenance cost of the oral cavity.

Description

technical field [0001] The invention belongs to the field of oral hygiene and health care, and in particular relates to a comprehensive functional toothpaste containing nano diamondene. Background technique [0002] Oral health is a mirror that reflects life and health, but modern life is fast-paced and work pressure is high. Compared with other diseases such as heart disease and high blood pressure, oral health problems are said to be ignored by people, and there are even "toothaches" among the people. It is not a disease" wrong statement. The focus of oral health is to remove food residues and dirt, control bacterial colonies, enhance physiological stimulation, and make the oral cavity and dental system have a clean and healthy environment. [0003] Toothpaste is the most important cleaning product for oral hygiene in daily life. With the continuous development of new materials and the continuous improvement of technology levels, various types of toothpaste have also com...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/19A61K8/20A61K8/60A61K8/43A61Q11/00A61P1/02
CPCA61K8/19A61K8/20A61K8/43A61K8/602A61K2800/28A61Q11/00
Inventor 郭留希赵清国何本锋刘永奇杨晋中张建华武艳强邵静茹穆小娜
Owner ZHENGZHOU ARTIFICIAL DIAMOND & PROD ENG TECH RES CENT