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A kind of hemostatic patch and preparation method thereof

A kind of patch, organic solvent technology, applied in the field of pharmaceutical preparations

Active Publication Date: 2018-12-18
贵州南方刺梨数字科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the preliminary research of the patent applicant, the root or root bark of Toddalia asiatica (L.) Lam. was used as raw material, crushed, extracted with ethanol solution, and then extracted with a solvent system, and the chloroform extraction layer was absorbed by macropores High-purity anise coumarin monomer was prepared by resin and preparation of HPLC. It has been proved by pharmacological experiments that it has significant hemostatic activity. The hemostatic drug preparations are still blank

Method used

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  • A kind of hemostatic patch and preparation method thereof
  • A kind of hemostatic patch and preparation method thereof
  • A kind of hemostatic patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment one (preparation of antibacterial hemostatic patch):

[0026] (1) Using the organic solvent dispersion method, mix 15g of anise coumarin with 3.3g of joint penetration enhancer, add 85g of MASCOS10 polyacrylic acid pressure-sensitive adhesive, and add 50mL of absolute ethanol;

[0027] (2) Seal and stir with a mechanical stirrer at a speed of 800 r min for 60 minutes to mix evenly to obtain a light yellow clear viscous liquid;

[0028] (3) Ultrasonic 20min is in order to remove air bubble on the ultrasonic extractor, obtain base material;

[0029] (4) Use an adjustable patch preparation knife to evenly spread the mixed solution on the anti-adhesive layer to form a glue with a thickness of about 0.3mm;

[0030] (5) Place it at room temperature for 30 minutes, place it in a constant temperature drying oven at 60°C for 20 minutes, evaporate the organic solvent to dry, cover the surface with a backing layer to obtain a patch, and cut it into an appropriate size....

Embodiment 2

[0032] Embodiment two (penetration enhancer screening experiment):

[0033] The improved Valia-Chien diffusion cell was used to screen out a natural transdermal absorption enhancer by different penetration enhancers on the permeability of the main active ingredients in Feilongzhang blood through isolated mouse skin, and the natural transdermal absorption enhancer was combined with The reasonable compatibility of anise coumarin can promote the transdermal absorption of hemostatic drugs and enhance the hemostatic activity.

[0034] Experimental method: after the rats were anesthetized, the abdomen was depilated, shaved with a razor, the abdominal skin was removed, the subcutaneous fat was removed and washed, and the water was repeatedly absorbed with filter paper until dry, and a trial-made patch with a suitable area was pasted on the horny skin. Then fix the mouse skin on the horizontal diffusion cell, add 2.5ml of phosphate buffer solution with pH 7.4 in the receiving cell as ...

Embodiment 3

[0043] Embodiment three (HPLC method measures the content of anise coumarin in the patch):

[0044] Get the anise coumarin hemostatic patch that embodiment 1 makes and carry out HPLC measurement, please see Figure 4 .

[0045](1) Chromatographic conditions

[0046] Column Diamonsil C 18 (250mm×4.6mm, 5μm)

[0047] Mobile phase methanol: 0.75% glacial acetic acid aqueous solution = 25:75

[0048] Elution mode Isocratic elution

[0049] Flow rate 1.0mL / min Detection wavelength 320nm

[0050] Column temperature 25°C Injection volume 20μL

[0051] The HPLC chromatogram of antibacterial hemostatic patch sample is shown in above-mentioned chromatographic condition Figure 4 .

[0052] (2) Sample preparation method

[0053] Take 5 pieces of this product, accurately weigh them, cut into small strips, mix well, accurately weigh 1 piece, remove the anti-adhesive layer, put it in a 100mL volumetric flask, add an appropriate amount of absolute ethanol, extract with supernatant fo...

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Abstract

The invention belongs to the field of medical preparations and relates to an antibacterial hemostatic adhesive plaster taking pimpinellin serving as a natural active component as a main drug and a preparation method of the antibacterial hemostatic adhesive plaster. The plaster consists of a backing layer made of a backing material, a drug-loaded pressure-sensitive layer containing the pimpinellin and an adhesion resisting layer; acrylate pressure-sensitive adhesives are used as a plaster matrix; peppermint oil, azone and isopropyl myristate are jointly used to serve as a skin penetration enhancer, wherein optimal doses of the peppermint oil, the azone and the isopropyl myristate are 12 percent, 6 percent and 4 percent of the dosage of a formula separately; by using the skin penetration enhancer, the absorption of the pimpinellin serving as the active component is effectively promoted; the prepared plaster is uniform in film formation and is moderate in viscosity; the drug is quickly and completely released; meanwhile, the influence of solvent addition on the adhesiveness of the pressure-sensitive adhesive is avoided. The research on pharmacodynamics shows that the hemostatic adhesive plaster has a good hemostatic effect which is equivalent to that of Yunnan Baiyao. The antibacterial hemostatic adhesive plaster and the preparation method thereof disclosed by the invention have the advantages of simple and convenient process, convenient operation, capability of realizing industrial production and good market prospect.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a hemostatic patch with a natural active ingredient anise coumarin as the main agent and a preparation method thereof. Background technique [0002] For a long time, ethnic minorities in Southwest China have used Toddalia asiatica (L.) Lam. as a hemostatic drug in clinical practice[1], and the herbal drug Toddalia asiatica (L.) Lam. is applied to the wound with root bark powder, and the To achieve the purpose of hemostasis, but the traditional usage has a large amount of medication, the dosage is not suitable for mastering, and it is easy to cause wound infection and other problems, and its hemostatic active ingredients are not clear[2]. It has been reported in the literature that certain coumarin chemical components have hemostatic activity. Tong Ruxin et al. [3] found that the coumarin component Bergapten in Rutaceae green pepper can significantly shorten the bleeding t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K31/366A61P7/04G01N30/02
CPCA61K9/7069A61K31/366G01N30/02G01N2030/027
Inventor 刘志刚谢晓林秦晋颖
Owner 贵州南方刺梨数字科技有限公司