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Traditional Chinese medicine composition for promoting construction of coronary collateral circulation

A technology of coronary arteries and compositions, applied in the field of traditional Chinese medicine compositions that promote the establishment of coronary artery collateral circulation, can solve problems such as liver function damage, achieve the goal of alleviating arteriosclerosis, promoting the establishment of coronary artery collateral circulation, and promoting revascularization Effect

Inactive Publication Date: 2016-07-13
SHANDONG PROVINCIAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The drugs currently used to promote the establishment of coronary artery collateral circulation are mainly statins, which may cause myolysis and liver function damage, and long-term use requires regular testing

Method used

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  • Traditional Chinese medicine composition for promoting construction of coronary collateral circulation
  • Traditional Chinese medicine composition for promoting construction of coronary collateral circulation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038]Proportions (parts by weight): 10 ginseng, 30 astragalus, 15 fleece-flower root, 10 dogwood, 10 pangolin, 2 leeches, 15 peony bark, 15 red peony, 15 zedoary, 30 gynostemma, 30 radishes, 15 schisandra, 15 dodder, atractylodes 10, Poria cocos 20, ginkgo biloba 15, epimedium 15, brown sugar 8.

[0039] Preparation:

[0040] (1) Grind the leeches into 80 mesh powders for subsequent use;

[0041] (2) Add ginseng, astragalus, Polygonum multiflorum, Cornus officinalis, Ginkgo biloba (single gauze bag) and Epimedium into 75% ethanol and extract once at 50-60°C (the amount of 75% ethanol is the total amount of the above six raw materials). 1.5 times of mass), leaching time 5 hours; then add 60% ethanol 50~60 ℃ and extract 1 time (the consumption of 60% ethanol is 1.2 times of the total mass of crude drug), leaching time 3 hours; The extract is finely filtered through a 200-mesh sieve, concentrated, dried to a moisture content of ≤10%, and then crushed to a particle size of 300-...

Embodiment 2

[0044] The clinical experiment of embodiment 2 Chinese medicine composition of the present invention

[0045] 1. Inclusion criteria

[0046] From June 2014 to June 2015, 100 patients with coronary heart disease angina pectoris and / or coronary heart disease myocardial infarction were admitted to the hospital, including 62 males and 38 females, aged 38-75 years. 100 patients were randomly divided into treatment group and control group, 50 cases each. Coronary angiography showed that 2 or more than 2 coronary arteries were narrowed or occluded by more than 75%, and all cases had complete and detailed medical history, electrocardiogram, laboratory examination and other clinical data. Exclusion criteria: patients with diabetes mellitus, severe cardiac insufficiency, malignant lesions, patients undergoing coronary artery bypass grafting, etc. who are not suitable for clinical observation of treatment effects.

[0047] 2. Treatment

[0048] Control group: basic treatments such as ...

Embodiment 3

[0061] Typical case of embodiment 3 Chinese medicine composition of the present invention

[0062] Case 1: Ma XX, male, 45 years old. She suffered from paroxysmal chest pain for 2 years and denied any history of hypertension or diabetes. The patient experienced precordial discomfort, dull pain, and fatigue during heavy physical activity, which lasted for about 10 minutes each time and relieved after rest. Half a year ago, there was an attack without obvious incentives, with dull pain in the precordial area, which lasted for about 5 minutes but accompanied by dizziness and amaurosis. Coronary angiography showed multiple lesions in multiple vessels, including 80% stenosis in the middle of the anterior descending branch; the proximal circumflex branch, The middle segment stenosis was 40% and 85% respectively; the proximal, middle and distal segments of the right coronary artery were 95%, 65% and 90% stenosis respectively. Diagnosed as coronary heart disease, exertional angina p...

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Abstract

The invention discloses a traditional Chinese medicine composition for promoting construction of coronary collateral circulation.The traditional Chinese medicine composition is prepared from ginseng, radix astragali, radix polygoni multiflori, fructus corni, squama manis, hirudo, cortex moutan, radix paeoniae rubra, rhizoma curcumae, herba gynostemmatis pentaphylli, radix ophiopogonis, fructus schisandrae chinensis, semen cuscutae, rhizoma atractylodis, poria, folium ginkgo, herba epimedii and red sugar.The traditional Chinese medicine composition can relieve arteriosclerosis, soften coronary vessels, expand arteriole and promote recanalization of blood vessels in the blocking state; the blood flow volume entering microcirculation is increased, the blood flow velocity is increased, microcirculation is improved, and revascularization of infarct myocardium is promoted; expression of vascular endothelial cell growth factors is improved, endothelial cell migration is promoted, surface integrated activity of endothelial cells is improved, proliferation of microvascular endothelial cells is promoted, a lumen structure is formed, new blood vessels are regenerated, and the effect of establishing coronary collateral circulation is achieved.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for promoting the establishment of coronary collateral circulation, which belongs to the technical field of traditional Chinese medicines. Background technique [0002] Coronary heart disease is one of the leading causes of death in humans worldwide. Coronary collateral circulation can reduce and change myocardial ischemia and myocardial infarction size, and the existence of a large number of good coronary collateral circulation has become an important factor in reducing adverse events (including fatality) caused by coronary heart disease. [0003] There are many side branches or anastomotic branches between the coronary artery and its branches. It is a potential pipeline. Under the physiological conditions of good blood supply of the coronary artery, these side branches or anastomotic branches do not participate in the circulation of the coronary artery. Only when the main coronary a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P9/00A61K35/62A61K35/36A61K31/7016
CPCA61K36/9066A61K31/7016A61K35/36A61K35/62A61K36/076A61K36/16A61K36/258A61K36/284A61K36/296A61K36/39A61K36/40A61K36/424A61K36/481A61K36/57A61K36/65A61K36/704A61K36/71A61K36/79A61K36/8968A61K2300/00
Inventor 刘继东
Owner SHANDONG PROVINCIAL HOSPITAL
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