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Selenium peptide nanometer self-emulsifying powder, and preparation method and application thereof

A self-emulsifying, nano-technology, applied in the directions of antidote, powder delivery, pharmaceutical formulations, etc., can solve problems such as unfavorable storage and transportation, complicated production process, capsule leakage, etc., and achieve improved oral bioavailability, stable physical and chemical properties, The effect of increasing the dissolution rate

Active Publication Date: 2016-07-27
ANHUI ZHONGGU BIOTECH CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, the common self-emulsifying preparations are mostly liquid at room temperature, which is not conducive to storage and transportation. When used, they are packaged in soft capsules or hard capsules, which makes the production process complicated, high in cost, and easy to be compatible with the capsule shell. Long-term storage may also cause capsule leakage, and there is also the disadvantage of a single dosage form

Method used

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  • Selenium peptide nanometer self-emulsifying powder, and preparation method and application thereof
  • Selenium peptide nanometer self-emulsifying powder, and preparation method and application thereof
  • Selenium peptide nanometer self-emulsifying powder, and preparation method and application thereof

Examples

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preparation example Construction

[0053] (1) Preparation of surfactant stock solution: Weigh an appropriate amount of soybean protein isolate (SPI) and dilute to 5% to 6% (wt%) with ultrapure water, stir magnetically until uniformly dispersed, and then adjust the solution to neutral , and heated to reflux to denature and inactivate SPI.

[0054] (2) Preparation of water-in-oil primary emulsion:

[0055] Maillard reaction of polypeptide-selenopolysaccharide-water solution system, the mass ratio of reaction substrate polypeptide to selenium polysaccharide is 1:1 or 1.1:1, the initial adjustment system is weakly alkaline, and the reaction temperature is controlled at 60°C to 90°C. Add a little FeCl 3 As a catalyst, reflux until the solution turns brown or reddish-brown, transfer to a 8k-14kDa dialysis bag and dialyze overnight in an atmosphere of ultrapure water, and collect the solution in the dialysis bag for later use.

[0056] Take the Millard reaction products (MRPs) solution of the above peptides and sele...

Embodiment 1

[0062] Embodiment 1 The preparation technology of a kind of selenopeptide nanometer self-emulsifying powder comprises:

[0063] (1) Take 4g soybean protein isolate and transfer it to a 100mL round bottom flask, add 56mL ultrapure water, stir magnetically at a speed of 200rpm / min at room temperature for 30min, then adjust the pH value to 7.0 with a 0.1M NaOH solution, Heating to reflux in an oil bath, keeping the temperature at 120°C for 30 minutes, cooling to room temperature and standing for 2 hours for later use, that is, the mother liquor of thermal decomposition product of soybean protein isolate (also known as SPI thermal decomposition liquid).

[0064] (2) Take 2g of polypeptide and add 80mL of ultrapure water to dissolve and adjust the pH value to 8.5, then add water to make the volume to 100mL. Take another 1g of selenium polysaccharide and 10mg of FeCl 3 Put the solid in a 100mL round-bottomed flask, add the aforementioned 2wt% polypeptide solution with a pH value of...

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Abstract

The invention discloses selenium peptide nanometer self-emulsifying powder, and a preparation method and application thereof. In a typical implementation scheme, the preparation method comprises the following steps that endogenic soy isolate protein is used as a hydrophilic and lipophilic nonionic surfactant; medium chain triglyceride with small irritation is used as an oil phase of a self-emulsifying system; selenium and polysaccharide is combined with polypeptide through maillard reaction to be used as biological active ingredients; freeze drying is performed after the milk formation; the selenium peptide nanometer self-emulsifying powder is prepared. The selenium peptide nanometer self-emulsifying powder provided by the invention has the excellent biocompatibility and bioavailability; the secondary solubility is good; the storage and the eating are convenient; the preparation process is simple; the quality is stable; the selenium peptide nanometer self-emulsifying powder is suitable for mass production.

Description

technical field [0001] The invention relates to a self-emulsifying preparation, in particular to the preparation and application of a selenopeptide nanometer self-emulsifying powder, and belongs to the field of food preparations. Background technique [0002] Selenium is an essential trace element for the human body. Certain diseases, such as cancer, tumor, and cardiovascular disease, are related to selenium deficiency in the body. However, selenium cannot be synthesized by the body and can only be taken in vitro. The main functional forms of selenium in the body are more than 30 selenoproteins, including glutathione peroxidase (GPX) family, thioredoxin reductase (TR) family, iodothyronine dehydration It is an important part of the iodothyroninedeiodinase (ID) family. Selenoprotein has physiological functions such as anti-oxidation, regulation of immunity, prevention and treatment of tumors, and scavenging free radicals. Inorganic selenium compounds are highly toxic, the m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/02A61K9/14A61K47/44A61P35/00A61P39/06A61P15/00A61P37/02A61P3/00A61K33/04
CPCA61K9/14A61K33/04A61K38/02A61K47/44A61K2300/00
Inventor 朱毅敏姚春霞丁晨毕德刘原彬
Owner ANHUI ZHONGGU BIOTECH CO LTD
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