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Drug-loaded hyaluronic acid nanofiber composite dressing and preparation method thereof

A hyaluronic acid and nanofiber technology, applied in the field of medical materials, can solve the problems of poor antibacterial function, heat insulation, anti-fouling, poor protein adsorption, etc., achieve strong moisturizing, improve anti-protein adsorption performance, source wide effect

Inactive Publication Date: 2016-08-03
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] What the present invention aims to solve is that the existing excipients containing hyaluronic acid have poor antibacterial function and other properties, such as poor heat insulation, anti-fouling, anti-protein adsorption, etc.

Method used

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  • Drug-loaded hyaluronic acid nanofiber composite dressing and preparation method thereof
  • Drug-loaded hyaluronic acid nanofiber composite dressing and preparation method thereof
  • Drug-loaded hyaluronic acid nanofiber composite dressing and preparation method thereof

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Effect test

Embodiment 1

[0031] A drug-loaded hyaluronic acid / nanofiber hydrogel dressing, comprising a hyaluronic acid macromonomer, the hydrogel structure formed by cross-linking the hyaluronic acid macromonomers and its composition with the nanofiber layer The composite dressing, its preparation method is:

[0032] a) Preparation of drug-loaded nanogel:

[0033] First prepare the drug-loaded lysine-based hydrogel: take 1 g of Lys-4 monomer and 0.7628 g of NA monomer, and at the same time mix 10 mg of triclosan antibacterial drug, dissolve it in 2 g of N, N-dimethyl In the acetamide, 1.59 g of triethylamine was added after it was completely dissolved, and the mixed solution was fully reacted in an oil bath at 80° C. for 1 hour to obtain a lysine-based hydrogel. The hydrogel was soaked in acetone for 4 hours, and then rinsed with deionized water to remove residual chemical substances to obtain a macromolecular hydrogel. Put 0.1 g of lysine-based hydrogel in 10 mL of PBS buffer (pH=7.4, 0.1 M) conta...

Embodiment 2

[0039] A drug-loaded hyaluronic acid-based hydrogel dressing, including hyaluronic acid macromonomers, the hydrogel structure formed by cross-linking the hyaluronic acid macromonomers and its composite with nanofiber layers Dressing, its preparation method is:

[0040] a) Preparation of drug-loaded nanogel:

[0041] First prepare the drug-loaded lysine-based hydrogel: take 1 g of Lys-4 monomer and 1.1442 g of NA monomer, and at the same time mix 20 mg of levofloxacin antibacterial drug, dissolve in 2 g of N, N-dimethylacetamide at 50 ° C 1.59 g of triethylamine was added after it was completely dissolved, and the mixed solution was fully reacted in an oil bath at 80° C. for 1 hour to obtain a lysine-based hydrogel. The hydrogel was soaked in acetone for 4 h, and then rinsed with deionized water to remove residual chemical substances to obtain lysine hydrogel. Put 0.1 g of lysine hydrogel in 10 mL of PBS buffer (pH=7.4, 0.1 M) containing 1 mg of trypsin, and degrade continuou...

Embodiment 3

[0047] A drug-loaded hyaluronic acid-based hydrogel dressing, including hyaluronic acid-based macromolecules, a hydrogel structure formed by cross-linking the hyaluronic acid-based macromolecules and a composite dressing composed of a nanofiber layer, Its preparation method is:

[0048] a) Preparation of drug-loaded nanogel:

[0049] First prepare the drug-loaded arginine-based hydrogel: Take 1 g of Arg-4 monomer and 0.7628 g of NA monomer, and at the same time mix 10 mg of chlorhexidine antibacterial drug, dissolve it in 2 g of N, N-dimethyl In acetamide, 1.59 g of triethylamine was added after it was completely dissolved, and the mixed solution was fully reacted in an oil bath environment at 80° C. for 1 hour to obtain an arginine-based hydrogel. After soaking the hydrogel in acetone for 4 hours, rinse it with deionized water to remove residual chemical substances to obtain a macromolecular hydrogel. Put 0.1 g of arginine-based hydrogel in 10 mL of PBS buffer containing 1 m...

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Abstract

The invention discloses a drug-loaded hyaluronic acid / nano fiber composite dressing and a preparation method thereof. The composite dressing comprises a hydrogel layer and a nanofiber layer formed by cross-linking hyaluronic acid macromers compounded with each other, and the drug-loaded nanogel is loaded in the hydrogel layer. The preparation method includes preparation of drug-loaded nanogel; synthesis of photo-crosslinkable or chemically crosslinkable monomers of hyaluronic acid macromolecules; The hyaluronic acid-based hydrogel is prepared; the hyaluronic acid-based hydrogel is combined with the nanofiber membrane to obtain a drug-loaded hyaluronic acid / nanofiber composite dressing. The raw materials used in the present invention have good biocompatibility. By combining two different structures of hydrogel and nanofiber, the wound exudate can be absorbed and diverted, and the overall stability of the dressing can be improved at the same time, which has long-acting antibacterial properties. , Anti-protein adsorption, anti-fouling, heat insulation and other functions.

Description

technical field [0001] The invention belongs to the technical field of medical materials, in particular to a drug-loaded hyaluronic acid-based / nanofiber composite dressing and a preparation method thereof. Background technique [0002] The skin has a self-healing function, but once the wound surface reaches the deep wound level, its repair function will be seriously reduced. Therefore, people use dressings to assist wound surface repair. Dressings are divided into traditional dressings and new dressings. Traditional dressings have many disadvantages such as easy adhesion to the wound during use, causing secondary damage, poor hemostasis, easy infection, and large dressing usage. The new dressing originated from the concept of "moist therapy" proposed by Dr. Winter of the University of London in 1962. He found in animal experiments that the healing speed in a closed humid environment is twice as fast as that of a dry wound exposed to the air, thus proposing that it can be tre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/42A61L15/44
CPCA61L15/44A61L15/28A61L15/42A61L2300/404
Inventor 吴德群朱婕俞建勇
Owner DONGHUA UNIV
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