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Mouthwash and preparation method thereof

A technology for mouthwash and purified water, applied in the field of medical and health care, can solve problems such as normal flora imbalance, mucosal ulceration, necrosis, etc., and achieve the effects of promoting proliferation, lowering blood sugar, and easy operation.

Active Publication Date: 2016-09-07
GUIZHOU YANGSHENG MEDICAL INSTR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

More and more studies have shown that long-term use of broad-spectrum antibacterial and antibacterial mouthwashes can cause an imbalance of normal bacterial flora in the oral cavity, resulting in symptoms of mucosal ulceration, demembrane and even necrosis, and in severe cases, it will lead to multiple ulcers

Method used

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  • Mouthwash and preparation method thereof
  • Mouthwash and preparation method thereof
  • Mouthwash and preparation method thereof

Examples

Experimental program
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experiment example

[0027] Adopt embodiment 1 gained mouthwash to carry out bacteriostatic experiment as experimental sample (carry out bacteriostatic experiment with embodiment 2 or embodiment 3 as experimental sample, method is identical), the bacterial strain that adopts in the bacteriostatic experiment is conventional oral pathogenic bacteria, Including: Staphylococcus aureus, Streptococcus mutans, Escherichia coli and Candida albicans.

[0028] AExperimental equipment:

[0029] Nutrient agar medium, rose bengal sodium medium, thioethanol medium, modified Martin medium, Petri dishes, beakers, Erlenmeyer flasks, inoculation loops, alcohol lamps, micropipettes, right-angled glass rods, Staphylococcus aureus, deformation Streptococcus, Escherichia coli, Candida albicans, experimental samples, reference substances, high-pressure steam sterilizer, 100mL stoppered test tube.

[0030] B experimental method:

[0031] (1) Preparation of medium:

[0032] Solid medium:

[0033] Nutrient agar medium ...

Embodiment 1

[0072] A mouthwash comprising the steps of:

[0073] (1) Weigh 0.1g of chitosan, 2g of fructooligosaccharide, 0.1g of sodium tripolyphosphate, 0.05g of aspartic acid and glutamic acid mixed in a mass ratio of 3:2, 0.1g of tea polyphenols, papain 0.05g, xylitol 1g, poloxamer 4g, purified water 92.6g;

[0074] (2) Divide the purified water into 4 parts on average by volume, get 1 / 4 volume of purified water to dissolve the chitosan, stir until the dissolution is complete, and then ultrasonically treat for 9 minutes to obtain an aqueous solution of chitosan;

[0075] (3) Add fructo-oligosaccharide in the chitosan aqueous solution, stir until dissolving completely, and filter with a filter membrane with an aperture of 0.45um to obtain filtrate A;

[0076] (4) Take another 1 / 4 volume of purified water to dissolve aspartic acid and glutamic acid, stir until the dissolution is complete, then add tea polyphenols and papain, continue stirring until the dissolution is complete, to obtai...

Embodiment 2

[0082] A mouthwash comprising the steps of:

[0083] (1) Weigh 0.5g of chitosan, 8g of xylooligosaccharide, 0.4g of sodium tripolyphosphate and potassium tripolyphosphate mixed in a mass ratio of 1:3, glutamic acid and leucine in a mass ratio of 3:1 0.2g, tea polyphenols 0.3g, papain 0.15g, xylitol 10g, sucrose ester 12g, purified water 68.45g;

[0084] (2) Divide the purified water into 4 parts on average by volume, get 1 / 4 volume of purified water to dissolve the chitosan, stir until the solution is complete, and then ultrasonically treat it for 20 minutes to obtain an aqueous solution of chitosan;

[0085] (3) Xylo-oligosaccharide is added in the chitosan aqueous solution, and after being stirred until dissolving completely, filter through a filter membrane with a pore size of 1 μm to obtain filtrate A;

[0086] (4) Take another 1 / 4 volume of purified water to dissolve glutamic acid and leucine, stir until the dissolution is complete, add tea polyphenols and papain, contin...

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Abstract

The invention discloses mouthwash and a preparation method thereof. Through being metered by the total mass of 100 percent, the mouthwash is prepared from the following raw materials in percentage by mass: 0.1 to 0.5 percent of chitosan, 2 to 8 percent of oligose, 0.1 to 0.4 percent of tripolyphosphate, 0.05 to 0.2 percent of compound amino acid, 0.1 to 0.3 percent of tea polyphenol, 0.05 to 0.15 percent of papain, 1 to 10 percent of xylitol, 4 to 12 percent of surfactants and the balance purified water. The raw materials are weighed according to the mass ratio; through the steps of dissolution, ultrasonic treatment, mixing, wet and hot sterilization and the like; the mouthwash is obtained. The mouthwash has the characteristics that the effective bacteriostasis is achieved; no toxic and side effects exist; harmlessness is realized on the normal flora in the oral cavity; the biosafety is high.

Description

technical field [0001] The invention belongs to the technical field of medical treatment and sanitation, and in particular relates to a mouthwash and a preparation method of the mouthwash. Background technique [0002] As far as the new concept of oral hygiene is concerned, only brushing teeth in the morning and evening can no longer meet the oral hygiene standards, but it is extremely unrealistic to take out toothbrush and toothpaste for oral cleaning anytime and anywhere. [0003] Mouthwash can clean the mouth, prevent dental caries and periodontitis, etc.; it is very convenient to use and can effectively resist the erosion of teeth by food and other residues; The best choice for health protection. [0004] At present, mouthwash can be roughly divided into fluoride mouthwash, anti-plaque mouthwash, anti-plaque mouthwash, anti-sensitivity mouthwash, herbal mouthwash and traditional Chinese herbal medicine mouthwash. These existing mouthwashes all belong to broad-spectrum ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/24A61K8/34A61K8/49A61K8/60A61K8/66A61Q11/00A61P1/02A61P31/04
CPCA61K8/24A61K8/345A61K8/498A61K8/60A61K8/66A61K8/736A61K2800/5922A61Q11/00
Inventor 黄昌平赵宁宁郑茂鑫杨义聂开品
Owner GUIZHOU YANGSHENG MEDICAL INSTR
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