Nano-grade beta-tricalcium phosphate and preparation method thereof

A tricalcium phosphate, nano-scale technology, applied in chemical instruments and methods, phosphorus compounds, inorganic chemistry, etc., can solve the problems of high site and production equipment requirements, easy mixing of other substances, complex processes, etc., to achieve simple steps, Guaranteed purity and safety, good bone conduction effect

Inactive Publication Date: 2017-01-04
花沐医疗科技(上海)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the method of preparing nano-sized β-TCP mainly adopts chemical synthesis method, which has the disadvantages of complex process, high requirements for site and production equipment, and easy mixing of other substances.

Method used

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  • Nano-grade beta-tricalcium phosphate and preparation method thereof
  • Nano-grade beta-tricalcium phosphate and preparation method thereof
  • Nano-grade beta-tricalcium phosphate and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The preparation of embodiment 1 nanoscale β-tricalcium phosphate

[0047] 1) Prepare micron-sized β-TCP particles that meet the β-TCP standard for surgical implants as raw materials;

[0048] 2) Disperse micron-sized β-TCP particles in a diethylene glycol dispersion, use zirconia beads as the ball milling medium, and continuously ball mill at a speed of 1800r / min for 12 hours;

[0049] 3) Centrifuge to remove diethylene glycol dispersion;

[0050] 4) Rinse with dichloromethane, dry in vacuum, and store.

Embodiment 2

[0051] Embodiment 2 transmission electron microscopy and dynamic light scattering analysis verification

[0052]The particle size of the β-TCP particles prepared in Example 1 was observed by a H-7000 transmission electron microscope, and the acceleration voltage used was 75KV. The particle size of the prepared β-TCP particles was tested by dynamic light scattering. The Zetasizer Nano-ZS potential and particle size analyzer was used to determine the particle size and Zeta potential of polymer drugs. Particle size measurement parameters: He-Ne laser (wavelength 635nm), refractive index and viscosity are n=1.333 and η=0.933cp respectively, measurement temperature is 25°C. Potential measurement parameters: He-Ne laser (wavelength 635nm), scattering angle θ=14°, measurement temperature 25°C.

[0053] Observing the prepared nano-sized β-TCP particles by TEM, the particles are in irregular shape, and the particle size range is 20-160nm (such as figure 1 A, B). Observation by dyna...

Embodiment 3

[0054] The preparation of embodiment 3 polylactic acid / nanometer β-tricalcium phosphate composite material

[0055] 1) Weigh nano-sized β-TCP particles and PLA in proportion according to requirements, wherein the content of β-TCP is 10wt%, 30wt%, 50wt% respectively, prepare a composite solution with dichloromethane, stir and ultrasonically mix to obtain PLA / nano β-TCP complex solution, the solution is poured into a flat-bottomed glass dish, and vacuum-dried to obtain a PLA / nano β-TCP complex film;

[0056] 2) Take the PLA / nano β-TCP composite film, melt and press it at 110°C and 260MPa to form a cylindrical parison of 10×20mm (diameter of the bottom surface×height), and hot press molding (the schematic diagram of hot pressing processing is shown in image 3 As shown, wherein 1 is a composite film, and the rest are processing molds), rapid cooling, and demoulding, the rods of high-strength PLA / nanometer β-TCP composite materials of different proportions can be obtained.

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Abstract

The invention discloses nano-grade beta-tricalcium phosphate and a preparation method thereof. A zirconium oxide bead is used as a ball milling medium, and beta-TCP particles are continuously subjected to ball milling for 8 to 16 hours in a diethylene glycol dispersion solution; under the action of high-speed rotation and intensive impacting and milling effect of a ball mill, micron-grade beta-TCP crystal particles are refined into nano-grade crystal particles. According to the preparation method provided by the invention, other chemical substances are not liable to mix; the particle diameter of machined particles is changed, while chemical and crystallization properties are not changed, so that the purity and the safety of the beta-TCP are guaranteed; the nano-grade beta-tricalcium phosphate can be used as a biodegradable material of a surgical implant.

Description

technical field [0001] The invention belongs to the field of orthopedic implant materials, in particular to a preparation method of nanometer beta-tricalcium phosphate, in particular to a method for preparing nanometer beta-tricalcium phosphate by a high-energy ball milling method. Background technique [0002] Human bone is composed of inorganic matter, organic matter and water, and the inorganic matter is mainly nano-sized hydroxyapatite. β-tricalcium phosphate (β-TCP) is the most common bioactive material, its calcium / phosphorus ratio is close to that of hydroxyapatite, similar to the inorganic components of bone matrix, and its degradation rate is faster than that of hydroxyapatite. Apatite, which can be well bonded to bone tissue and has good biocompatibility, has been widely used clinically. As a biodegradable material, β-TCP can be made into a porous scaffold material alone for the repair of bone defects in various parts, or it can be combined with organic materials ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32A61L27/46A61L27/56A61L27/58
CPCC01B25/32A61L27/46A61L27/56A61L27/58A61L2430/02C01P2004/04C01P2004/62C08L67/04
Inventor 董健曹露江立波陈谦李熙雷周晓岗殷潇凡
Owner 花沐医疗科技(上海)有限公司
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