Temperature-sensitive postoperative adhesion cellulose modifying material and preparation method and application thereof

Abstract

The invention discloses a temperature-sensitive postoperative adhesion cellulose modifying material and a preparation method and application thereof. Sulfobetaines type zwitterionic monomers with anti-cell-adhesion or protein non-specificity adsorption property are grafted and co-polymerized onto a temperature-sensitive methylcellulose main chain, and a grafted copolymer aqueous solution is prepared by a low-temperature dissolution method. At the room temperature, the grafted copolymer aqueous solution is viscous liquid which is easy to inject or coat, can become hydrogel spontaneously and rapidly at the temperature of the human body, and has reversible sol-gel phase transformation characteristic. The temperature-sensitive postoperative adhesion cellulose modifying material is good in biological compatibility, and high in cell adhesion resistance and tissue adhesion resistance, is suitable for adhesion prevention of complicated surgical wounds or wound parts, and has high operation convenience and postoperative adhesion prevention effectiveness.

Description

technical field [0001] The invention belongs to the technical field of preparation of biomedical hydrogel materials, and in particular relates to a temperature-sensitive anti-postoperative adhesion cellulose modified material and a preparation method and application thereof. Background technique [0002] With the development of a large number of surgical operations, the problem of postoperative biological tissue adhesion has become increasingly prominent. Adhesions are generally abnormal structures formed by the abnormal connection between the wound site and surrounding tissues or organs caused by trauma, infection or other factors after surgery. Postoperative adhesions not only affect the effect of surgery, but also lead to serious postoperative complications, such as small bowel obstruction, pelvic adhesions in women, etc., which make the operation fail. Therefore, finding effective ways to prevent postoperative adhesions has always been an important topic in the field of...

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Problems solved by technology

Commonly used anti-adhesion barrier materials mainly contain the following three categories: one is solid film materials, such as a postoperative anti-adhesion film material disclosed in patent CN103044700A, a postoperative anti-adhesion polymer film disclosed in patent CN104436317A, etc., such materials Because it has been preformed, it is not easy to operate during the operation and it is difficult to apply to some complicated wound sites, so its application is limited; the second type is water liquid substances, such as a kind of anti-adhesion washing liquid for surgery disclosed in patent CN103271939A, this type The material has good fluidity and can be injected or applied to complex wound sites, but it is easy to lose, the barrier time is not long enough, and the effect is limited; the third is hydrogel substances, which have fluidity under certain conditions and can also be injected Or coated on complex surgical wounds or wound sites, and the barrier time is relatively long, such as the in situ cross-linkable two-component hydrogel reported by Yeo et al. (Biomaterials, 2006, 27:4698-4705; Biomaterials, 2007 ,28:3418-3426), but a certain toxic chemical cross-linking agent was used in its preparation

Considering the mechanism of preventing postoperative tissue adhesion, to successfully apply the relevant physical barrier means to prevent postoperative adhesion, the anti-adhesion barrier material should have good anti-protein non-specific adsorption or cell adhesion performance, but the above-mentioned physical barrier materials are generally Does not have this performance, resulting in unsatisfactory application effect

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