Preparation method for amphiphilic segmented copolymer with pH value and temperature sensitivities

Abstract

The invention relates to a preparation method for an amphiphilic segmented copolymer with pH value and temperature sensitivities. The preparation method comprises the following steps: by adopting a reversible addition-fragmentation chain transfer polymerization process, synthesizing a macromolecular chain transfer agent namely tert-butyl polyacrylate, and subjecting the tert-butyl polyacrylate with dimethylaminoethyl methacrylate and ethylene glycol monomethyl ether methacrylate to the reversible addition-fragmentation chain transfer (RAFT) polymerization process again so as to synthesize the amphiphilic segmented copolymer P(tBA)-b-P(DMAEMA-co-PEGMA. The segmented copolymer provided by the invention can self-assemble to form micelles in an aqueous solution, and has pH value and temperature sensitivities, wherein the micelles have a critical pH value of 7 and a critical temperature of 37.5 DEG C. The preparation method provided by the invention has the advantages of high yield, relatively wide applicable monomer range, low requirements on reaction conditions, simple and convenient operation, greenness and environmental friendliness; and the amphiphilic segmented copolymer prepared by using the method provided by the invention has double pH value and temperature sensitivities and broad application prospects, and can be applied to the chemical production fields like dye adsorption, the environment protection fields like heavy metal pollution treatment, and the biomedical fields like controllable release of insoluble drugs.

Description

technical field [0001] The invention belongs to the technical field of chemical engineering and new materials, in particular to a pH- and temperature-sensitive amphiphilic multi-block copolymer P(tBA)- b -P(DMAEMA- co - PEGMA) preparation method. Background technique [0002] Environmentally responsive polymer materials refer to polymer materials that undergo some obvious physical or chemical property mutations in the case of minor external environment changes. Such materials usually undergo conformational adjustments in specific environments to respond to Responsive responses to environmental changes lead to phase structure transitions. Utilizing this characteristic of environmentally responsive polymer materials, smart materials with special responsiveness can be designed according to requirements. Amphiphilic multi-block copolymers can self-assemble in some selective solvents to form specific structures such as micelles and vesicles. Combining the advantages of the abo...

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Problems solved by technology

[0004] GTP is currently widely used in the synthesis of polymethacrylate responsive polymers, but GTP is not based on a free radical mechanism, and its synthesis is limited to methyl methacrylate monomers, while the reaction rate of NMP polymerization in CLRP Low, the range of applicable monomers is narrow; the disadvantage of ATRP polymerization is that it cannot be applied to the direct polymerization of acidic, basic, amide or halogen-containing vinyl monomers, and metal elements are used in the reaction process

Although with the continuous improvement of ATRP technology, the amount of metal elements is greatly reduced, but from the perspective of applicable environment and toxicology, the problem of using metal elements is inevitable, so the development of ATRP polymerization method is limited, especially in biological This problem is particularly prominent when applied in the medical field

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