Preparation method of medical pure magnesium surface electrophoretic deposition carried bone growth inducing traditional Chinese medicine coating

An electrophoretic deposition and bone growth technology, which is applied in the field of preparation of medical pure magnesium surface coatings, can solve the problems of easy peeling off of the coating, loss of protective effect, low bonding strength of the coating or film and the substrate, and achieve antibacterial biological activity , excellent biological activity, excellent antibacterial effect

Inactive Publication Date: 2017-05-17
JIAMUSI UNIVERSITY
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Problems solved by technology

But when we sorted out and analyzed the research results, we found that: (1) A key problem restricting the clinical application of magnesium alloys as bone internal fixation materials is how to match the degradation rate in vivo with the bone tissue regeneration or fracture healing rate, especially Early degradation control; (2) There are few studies on the degradation products of medical magnesium alloy surface modification coatings in vivo. How does it affect cell activity and antibacterial properties? The deposition, absorption and interaction of degradation products in vivo are issues that cannot be ignored. (3) Most of the surface modification methods of medical m

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  • Preparation method of medical pure magnesium surface electrophoretic deposition carried bone growth inducing traditional Chinese medicine coating
  • Preparation method of medical pure magnesium surface electrophoretic deposition carried bone growth inducing traditional Chinese medicine coating
  • Preparation method of medical pure magnesium surface electrophoretic deposition carried bone growth inducing traditional Chinese medicine coating

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specific Embodiment approach 1

[0057] Specific Embodiment 1: This embodiment is a method for preparing a coating of traditional Chinese medicine for inducing bone growth by electrophoretic deposition on the surface of medical pure magnesium. Specifically, it is carried out according to the following steps:

[0058] 1. Pretreatment of the surface of the pure magnesium sample: use sandpaper to roughly grind the surface of the pure magnesium sample to be treated, then use acetone and distilled water to sonicate each for 25 minutes, dry it, put it in a sealed bag and seal it for later use;

[0059] 2. Configure the micro-arc oxidation electrolyte: put distilled water into the beaker, then add sodium silicate, potassium hydroxide, potassium fluoride and disodium ethylenediaminetetraacetate in sequence, and stir well after each reagent is added Then add the next reagent, after adding all the reagents, perform ultrasonic oscillation until all the reagents are completely dissolved to obtain the micro-arc oxidation e...

specific Embodiment approach 2

[0065] Specific embodiment two: the difference between this embodiment and specific embodiment one is: the concentration of sodium silicate in the micro-arc oxidation electrolyte described in step 2 is 15g / L, and the concentration of potassium hydroxide is 10g / L, The concentration of potassium fluoride is 8 g / L, and the concentration of disodium edetate is 1 g / L. Others are the same as the first embodiment.

specific Embodiment approach 3

[0066] Specific embodiment three: the difference between this embodiment and specific embodiment one is: the traditional Chinese medicine in the traditional Chinese medicine solution described in step four (2) is Eucommia chlorogenic acid, and the solvent is water. Others are the same as the first embodiment.

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Abstract

The invention discloses a preparation method of a medical pure magnesium surface electrophoretic deposition carried bone growth inducing traditional Chinese medicine coating, and relates to a preparation method of a medical pure magnesium surface coating, in order to solve the technical problems that the existing medical magnesium and magnesium alloy materials are too high in degradation rates and cause inflammatory reaction. The preparation method comprises the following steps: one, pure magnesium specimen surface pretreatment is carried out; two, a micro-arc oxidation electrolytic solution is prepared; three, ultrasound micro-arc oxidation treatment is carried out; and four, post treatment is carried out. According to the preparation method, after magnesium and magnesium alloy ultrasound micro-arc oxidation is carried out, electrophoretic deposition is carried out on a hydrophilic and hydrophobic carried purified traditional Chinese medicine coating, after assembly, the matching between a degradation rate and an osseous tissue regenerating or fracture healing rate in vivo is achieved, the surface carried purified traditional Chinese medicine coating has antibacterial and antiphlogistic properties and bone tissue regeneration inducing property; the influencing mechanism of hydrophilic and hydrophobic medicine carrying surfaces on the antibacterial property, the corrosion resistance and the degradation property of the traditional Chinese medicine coating is provided; and a magnesium bone internal fixation material has good mechanical properties of a metallic material, and has corrosion resistance, antibacterial property and excellent bioactivity.

Description

technical field [0001] The invention relates to a preparation method of a medical pure magnesium surface coating. Background technique [0002] Magnesium and magnesium alloys have become a research hotspot. Many scholars have conducted extensive research on the use of magnesium alloys in porous tissue engineering scaffolds, vascular scaffolds, and bone implant materials. The problem of mismatching fracture healing speed. How to effectively improve the problems of too fast degradation rate and poor corrosion resistance of magnesium-based metals? Only by studying the degradation mechanism of medical magnesium alloys in vivo can we find an effective way to solve the problems. [0003] Traditional Chinese medicine has a long history, rich sources, convenient materials, simple usage, remarkable curative effect, and mild side effects, so it has attracted much attention. Eucommia ulmoides was first recorded in "Shen Nong's Materia Medica", which has the functions of nourishing li...

Claims

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Application Information

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IPC IPC(8): C25D11/30C25D13/10
CPCC09D5/448C25D11/30
Inventor 王晶彦李慕勤张德秋彭书浩
Owner JIAMUSI UNIVERSITY
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