Preparation method of medical pure magnesium surface electrophoretic deposition carried bone growth inducing traditional Chinese medicine coating

Abstract

The invention discloses a preparation method of a medical pure magnesium surface electrophoretic deposition carried bone growth inducing traditional Chinese medicine coating, and relates to a preparation method of a medical pure magnesium surface coating, in order to solve the technical problems that the existing medical magnesium and magnesium alloy materials are too high in degradation rates and cause inflammatory reaction. The preparation method comprises the following steps: one, pure magnesium specimen surface pretreatment is carried out; two, a micro-arc oxidation electrolytic solution is prepared; three, ultrasound micro-arc oxidation treatment is carried out; and four, post treatment is carried out. According to the preparation method, after magnesium and magnesium alloy ultrasound micro-arc oxidation is carried out, electrophoretic deposition is carried out on a hydrophilic and hydrophobic carried purified traditional Chinese medicine coating, after assembly, the matching between a degradation rate and an osseous tissue regenerating or fracture healing rate in vivo is achieved, the surface carried purified traditional Chinese medicine coating has antibacterial and antiphlogistic properties and bone tissue regeneration inducing property; the influencing mechanism of hydrophilic and hydrophobic medicine carrying surfaces on the antibacterial property, the corrosion resistance and the degradation property of the traditional Chinese medicine coating is provided; and a magnesium bone internal fixation material has good mechanical properties of a metallic material, and has corrosion resistance, antibacterial property and excellent bioactivity.

Description

technical field [0001] The invention relates to a preparation method of a medical pure magnesium surface coating. Background technique [0002] Magnesium and magnesium alloys have become a research hotspot. Many scholars have conducted extensive research on the use of magnesium alloys in porous tissue engineering scaffolds, vascular scaffolds, and bone implant materials. The problem of mismatching fracture healing speed. How to effectively improve the problems of too fast degradation rate and poor corrosion resistance of magnesium-based metals? Only by studying the degradation mechanism of medical magnesium alloys in vivo can we find an effective way to solve the problems. [0003] Traditional Chinese medicine has a long history, rich sources, convenient materials, simple usage, remarkable curative effect, and mild side effects, so it has attracted much attention. Eucommia ulmoides was first recorded in "Shen Nong's Materia Medica", which has the functions of nourishing li...

AI Technical Summary

Problems solved by technology

But when we sorted out and analyzed the research results, we found that: (1) A key problem restricting the clinical application of magnesium alloys as bone internal fixation materials is how to match the degradation rate in vivo with the bone tissue regeneration or fracture healing rate, especially Early degradation control; (2) There are few studies on the degradation products of medical magnesium alloy surface modification coatings in vivo. How does it affect cell activity and antibacterial properties? The deposition, absorption and interaction of degradation products in vivo are issues that cannot be ignored. (3) Most of the surface modification methods of medical magnesium alloys use a single technology, each with its advantages and disadvantages, such as the preparation of coatings on the surface of magnesium alloys or the low bonding strength between the film and the substrate, the coating is easy to fall off, and the protective effect is lost prematurely; (4 ) surface modification of medical magnesium alloys, the pharmacological mechanism of drug-loaded coatings to induce bone growth is seldom studied

[0005] Magnesium and magnesium alloys have the Achilles heel of rapid degradation and inflammatory response, which seriously hinders the development of magnesium and magnesium alloy materials in the field of clinical application

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