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Composite tissue repair patch and preparation method and application thereof

A composite tissue and patch technology, which is applied in tissue regeneration, pharmaceutical formulations, prostheses, etc., can solve the problems of small porosity of composite patches and complex composite processes, and achieves a simple method, promotes regeneration, and is not easy to delaminate. Effect

Active Publication Date: 2017-05-24
MEDPRIN REGENERATIVE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the melting point of the adhesive layer material used must be much lower than the melting point of the electrospinning film material to prevent damage to the structure of the electrospinning film layer in the subsequent hot pressing process. The compounding process is more complicated, and the composite patch less porosity

Method used

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  • Composite tissue repair patch and preparation method and application thereof
  • Composite tissue repair patch and preparation method and application thereof
  • Composite tissue repair patch and preparation method and application thereof

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preparation example Construction

[0096] The present invention also provides a preparation method of the composite tissue repair patch according to the present invention, comprising:

[0097] Composite step: preparing an adhesive material solution, and compounding the nanofiber membrane and the woven mesh with the adhesive material solution to obtain the composite tissue repair patch; preferably, by freeze-drying process or coating process or casting The process is to compound the nanofiber film and the woven mesh with the adhesive material solution.

[0098] According to the method of the present invention, wherein the molecular weight of the adhesive material and / or the concentration of the adhesive material solution are adjusted so that the adhesive material solution overflows from the pores of the woven mesh and A layer of anti-adhesion solution was formed on the side opposite to the side where the nanofibrous membrane was located. Preferably, by controlling the molecular weight of the adhesive material a...

Embodiment 1

[0138]

[0139] Polylactic acid (PLLA) was dissolved in hexafluoroisopropanol solution, wherein the concentration of polylactic acid was 5% (g / mL), stirred and dissolved to obtain a uniform polymer solution. Place the polymer solution in the electrospinning syringe, adjust the rate of the micro-injection pump to 8mL / h, adjust the voltage of the high voltage generator to 15kV, adjust the receiving distance of the receiving device to 15cm, and perform electrospinning. The electrospinning was turned off after the layer thickness reached 0.15 mm, and the nanofibrous membrane was obtained.

[0140]

[0141] Weigh 20g of hydroxyethyl cellulose and dissolve it in 100mL of purified water, add 0.8g of calcium chloride, and adjust the pH of the solution to 4 with acetic acid, stir and dissolve evenly; add 0.8mL of glutaraldehyde solution (mass concentration is 25%), and control The reaction temperature is 65° C., and the modification treatment is carried out for 60 minutes; an adhes...

Embodiment 2

[0146]

[0147] Poly DL-lactic acid (PDLLA) was dissolved in hexafluoroisopropanol solution, wherein the concentration of poly DL-lactic acid was 10% (g / mL), stirred and dissolved to obtain a uniform polymer solution. Place the polymer solution in the electrospinning syringe, adjust the rate of the micro-injection pump to 7mL / h, adjust the voltage of the high-voltage generator to 20kV, adjust the receiving distance of the receiving device to 15cm, and perform electrospinning. The electrospinning was turned off after the layer thickness reached 0.2 mm, and the nanofibrous membrane was obtained.

[0148]

[0149] Weigh 10g of sodium carboxymethylcellulose and dissolve it in 100mL of purified water, add 0.5g of calcium chloride, adjust the pH of the solution to 3 with dilute hydrochloric acid, stir and dissolve evenly. Add 0.5 mL of glutaraldehyde solution (mass concentration: 25%), and control the reaction temperature at 70° C., and perform modification treatment for 40 min....

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Abstract

The invention relates to a composite tissue repair patch and a preparation method and application thereof. The composite tissue repair patch comprises a nanofiber membrane, a woven mesh and an adhesive material, wherein the adhesive material is located between the nanofiber membrane and the woven mesh; the adhesive material contains hydrophilic substances, the nanofiber membrane and the woven mesh are bonded through the adhesive material, and the adhesive material is embedded into pores of the nanofiber membrane and the woven mesh; the peel strength between the nanofiber membrane and the woven mesh is 20-75 cN / mm; the breaking strength of the composite tissue repair patch is 8-12.5 Mpa; preferably, the breaking elongation of the composite tissue repair patch is 20%-250%; more preferably, the porosity of the composite tissue repair patch is 50%-90%. The composite tissue repair patch is not likely to be layered and has the good mechanical property and soft characteristic.

Description

technical field [0001] The invention relates to a composite tissue repair patch and its preparation method and application, belonging to the field of implanted medical materials. Background technique [0002] Currently, commonly used tissue repair patches include woven mesh and electrospun nanofiber membrane. The woven mesh has good mechanical properties and can provide sufficient mechanical support. However, due to problems such as high hardness, rough surface, and easy adhesion with tissues in the woven mesh, it is difficult to obtain an ideal repair effect. [0003] Electrospun nanofibrous membrane has the characteristics of large specific surface area, high porosity and high surface energy, which can be used as a porous scaffold for cell growth and promote cell migration; it also has a three-dimensional porous structure, which is easy to transport nutrients and oxygen to benefit cells. proliferation and differentiation. Therefore, the electrospun nanofibrous membrane ...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/24A61L27/22A61L27/16A61L27/18A61L27/20A61L27/54A61L27/58A61F2/00
CPCA61L27/16A61L27/18A61L27/20A61L27/222A61L27/227A61L27/24A61L27/54A61L27/58A61F2/0063A61L2400/12A61L2430/34C08L5/08C08L1/286C08L67/04C08L23/12
Inventor 李林静邓坤学袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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