Titanium alloy implant composite material and preparation and application thereof

A technology of composite materials and titanium alloys, applied in the direction of electrolytic inorganic material coating, prosthesis, details involving processing steps, etc.

Inactive Publication Date: 2017-06-30
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Up to now, the preparation of this systematic, highly reducible and highly co

Method used

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  • Titanium alloy implant composite material and preparation and application thereof
  • Titanium alloy implant composite material and preparation and application thereof
  • Titanium alloy implant composite material and preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] 1. Preparation of titanium alloy implant base

[0042] (1) CT scan the patient's bone structure (GE LightSpeed ​​16-slice spiral CT) to collect damaged bone structure data, and save the data in DICOM format;

[0043] (2) Input the obtained CT scan data into the Materialise three-dimensional modeling software (MaterialiseMagics20), perform threshold division, and then use the area growth method to remove the noise of the imported image, remove redundant data, and segment the damaged bone structure area;

[0044] (3) Use Materialise three-dimensional modeling software to open calculations to obtain the three-dimensional structure data of the damaged bone structure, and then input the obtained three-dimensional data into the UG software (NX9.0) to obtain the digital three-dimensional model of the bone defect, and carry out the repair design of the bone defect;

[0045] (4) Use computer-aided software (CAD) (AutoCAD2010) to design the bone defect module according to the design of bo...

Embodiment 2

[0064] Steps (1) to (4) are the same as the conditions in Example 1;

[0065] Step (5) Change the laser power in step (5) of Example 1 to 250W, the scanning speed of 1300mm / s, the annealing temperature to 700°C, and the holding time for 7 hours;

[0066] Step (6) Change the composition of the micro-arc oxidation solution in step (6) of Example 1 to: 8g / L Na 2 SiO 3 , 10g / LNa 3 PO 4 , 8g / L NaOH, 3g / L KF, 3g / L Na 2 CO 3 , 1g / L KOH, 50mL / L absolute ethanol, the solvent is deionized water, the pH value is natural. The control parameters of micro-arc oxidation are changed to: frequency is 550Hz, micro-arc time is 15min, duty cycle is 15%, current density is 15A / cm 2 , The other conditions remain unchanged; the titanium alloy implant matrix / micro-arc oxide film layer is obtained, and the contact angle diagram is shown Figure 4 Shown.

[0067] Step (7) Change the composition of the electrochemical deposition solution in step (7) of Example 1 to: 0.042mol / L Ca(NO 3 ) 2 , 0.025mol / L NH 4 H 2...

Embodiment 3

[0073] Steps (1) to (4) are the same as the conditions in Example 1;

[0074] Step (5) Change the laser power in step (5) of Example 1 to 250W, the scanning speed is 1500mm / s, the annealing temperature is changed to 800°C, and the holding time is 8 hours;

[0075] Step (6) Change the composition of the micro-arc oxidation solution in step (6) of Example 1 to: 12g / L Na 2 SiO 3 , 12g / LNa 3 PO 4 , 10g / L NaOH, 7g / L KF, 8g / L Na 2 CO 3 , 5g / L KOH, 100mL / L absolute ethanol, deionized water as solvent, natural pH. The control parameters of micro-arc oxidation are changed to: frequency is 650Hz, micro-arc time is 30min, duty cycle is 30%, current density is 25A / cm2, and other conditions remain unchanged;

[0076] Step (7) Change the composition of the electrochemical deposition solution in step (7) of Example 1 to: 0.042mol / L Ca(NO 3 ) 2 , 0.025mol / L NH 4 H 2 PO 4 , 0.5mol / L NaNO 3 , 50mL / L absolute ethanol, 50mL / L hydrogen peroxide, 0.006mol / L alkylphenol polyoxyethylene ether OP-21, 0.0008m...

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Abstract

The invention discloses a titanium alloy implant composite material and preparation and an application thereof. The titanium alloy implant composite material is prepared by the following steps of: by taking a model manufactured from titanium alloy powder through 3D printing as a titanium alloy implant substrate, forming a micro-arc oxidation layer on the surface of the titanium alloy implant substrate through a micro-arc oxidation method; then forming a hydroxyapatite layer or a hydroxyfluorapatite layer on the surface of the micro-arc oxidation layer by means of an electrochemical deposition method; and finally, immersing the surface of the hydroxyapatite layer or the hydroxyfluorapatite layer to form a polylactic acid layer. According to the material provided by the invention, individual development of the titanium alloy implant material is realized from data acquisition of an original damaged bone structure to preparation of a final multi-coating composite material, so that the high quality titanium alloy implant composite material is obtained. A polarizing test shows that the anti-corrosive property of the material can be enhanced by 2-3 orders of magnitudes, and osteoblast cultivation shows that the titanium alloy composite material has a better osteocyte promoting ability.

Description

[0001] (1) Technical field [0002] The invention relates to a titanium alloy multilayer biocomposite material with good biocompatibility and a preparation method thereof, namely, by scanning the damaged bone structure of the human body with a multilayer spiral CT, and then processing and repairing the original data, and then passing 3D printing, micro-arc oxidation, electrochemical deposition, biopolymer layer preparation and other methods to prepare implants with titanium alloy / micro-arc oxidation film layer / hydroxyapatite (or fluorohydroxyapatite) / biopolymer layer structure Body composite materials. [0003] (2) Background technology [0004] Titanium and titanium alloy materials are widely used in the fields of artificial joints and dental implants due to their good biological activity, biomechanical properties and chemical properties. At present, the methods for preparing biomedical titanium alloys mainly include: vapor deposition, powder metallurgy, spark plasma sintering, etc...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/32A61L27/34A61L27/56A61L27/54A61L27/06C25D11/26C25D9/04G06T17/00G06T11/00G06T7/11G06T7/187G06T5/00
CPCA61L27/32A61L27/06A61L27/34A61L27/54A61L27/56A61L2300/412A61L2430/02C25D9/04C25D11/026C25D11/26G06T5/002G06T11/008G06T17/00G06T2200/08G06T2207/10081G06T2207/30008G06T2210/41C08L67/04
Inventor 金杰郑大才段和洁朱峥栩
Owner ZHEJIANG UNIV OF TECH
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