Up-conversion luminescent nano-sensing material for detection of arginine and application thereof in detection of the arginine
A sensing material, arginine technology, applied in the field of ratiometric luminescence upconversion nano-sensing materials, can solve the problems of biological damage, poor tissue penetration ability, etc., achieve small damage, strong tissue penetration ability, and good stability Effect
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[0030] The preparation of compound 1 adopts the following synthetic route:
[0031]
[0032] 1) Synthesis of 3-pyrrolidinyl-1-phenol (compound 6):
[0033] 3-Aminophenol (1.0913 g, 10.0 mmol), potassium carbonate (1.5203 g, 11.0 mmol) and 1,4-dibromobutane (1340 μL, 11.0 mmol) were dissolved in 10 mL of DMF. Heated to 80°C, reacted for 2 hours, and cooled to room temperature. Purified by column (developing solvent: ethyl acetate:petroleum ether=1:10) to obtain 3-pyrrolidinylphenol, yield: 58.8%.
[0034] Characterized as follows: 1 H NMR (400MHz, DMSO-d 6 , TMS): δ H 7.10(t, 1H), 6.19(t, 2H), 6.09(s, 1H), 4.86(s, 1H), 3.28(t, 4H), 2.02(t, 4H). 13 C NMR (100MHz, DMSO-d 6 ):δ C 156.55, 149.47, 130.06, 104.81, 102.57, 98.69, 47.71, and 25.44.
[0035] 2) Synthesis of 2-nitroso-5-pyrrolidine-1-phenol (compound 5):
[0036] 3-Pyrrolidinylphenol (324.6 mg, 2 mmol) was dissolved in 12 ml of concentrated hydrochloric acid (37 wt%) and 4 mL of water mixed solvent, and 4...
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