Preparation method of biphasic calcium phosphate composite powder synthesized by high-temperature solid-state reaction

Abstract

The invention discloses biphase calcium phosphate (BCP) composite powder synthesized by a high-temperature solid phase reaction. BCP powder is biphase composite powder prepared from hydroxyapatite (HA) and beta-tricalcium phosphate (beta-TCP), in which the molar ratio Ca / P of calcium to phosphorus is 1.5 to 1.67, wherein the value ranges of the relative mass percent of HA and beta-TCP two phases are each 1 to 99 percent; the sizes of crystalline grains of the HA and beta-TCP two phases are 20nm to 300 microns; the crystallinity is 50 to 100 percent. The invention also discloses a preparation method of the BCP composite powder synthesized by the high-temperature solid phase reaction. The BCP composite powder is prepared through the high-temperature solid phase reaction of a calcium-containing solid compound and a calcium-phosphorus solid containing compound. The BCP composite powder has the advantages that a reaction period is short; the costs of raw materials are low; the equipment investment is low; no waste gas and waste water are discharged; further, the proportion of the HA and beta-TCP two phase in the BCP powder is easily regulated and controlled at the same time; the two phases are distributed uniformly; the sizes of the crystal grains and the crystallinity are controllable; finally; the production requirement that the compression strength of BCP biphase composite ceramic is improved or a degradation speed is regulated and controlled is met.

Description

Technical field [0001] The invention relates to the technical field of bioactive materials and orthopedic implants, in particular to a method for preparing hydroxyapatite and β-tricalcium phosphate dual-phase composite powder synthesized by high-temperature solid-phase reaction. Background technique [0002] Bone transplantation is the main method to treat bone defects. Autologous bone transplantation, as the gold standard of bone transplantation, has achieved good results in clinical practice, but its sources are limited, and there are surgical complications of bone removal. The source of allogeneic demineralized bone is limited and there is immunogenicity, unstable osteoinduction, long-term absorption, and risk of infection during the perioperative period and later. Hydroxyapatite (HA) has excellent biocompatibility, can conduct bone regeneration faster, and can directly bond with bone without passing through an intermediate medium. However, the hydroxyapatite obtained by the ...

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Problems solved by technology

However, this method involves the formation of sol and gel and the calcination process of gel, which is not only complicated in process, but also has polluting gas emissions. The reaction uses ester as a raw material and requires higher cost, so it is not suitable for industrialized mass production.

[0008] (5) Calcium-deficient hydroxyapatite (CDHA) is synthesized by a liquid phase method, and then calcined at about 700°C to partially decompose it to obtain a two-phase composite powder of HA and β-TCP, but this The CDHA used in the process method is usually produced by the liquid phase method. Therefore, it not only has the inherent environmental protection problems of the liquid phase method, but also it is difficult to obtain a large range of HA / β-TCP phase ratio and stable content through the control of process parameters during the calcination process. , uniformly distributed two-phase structure, and cannot effectively control the grain size and crystallinity of each phase of HA and β-TCP

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