A method for surface modification of metal materials and its product and application

Abstract

The invention discloses a method for modifying the surface of a metal material. By using the two-step gas plasma immersion ion implantation technology and chemical covalent grafting, antimicrobial peptide is formed on the surface of the metal material in a covalent grafting mode. According to the method, on the one hand, the main body property of the metal material is not affected, and clinical research and application are easier to achieve; the antimicrobial peptide has the characteristics that the antimicrobial spectrum is wide, and drug resistance is not liable to occur, and the antimicrobial peptide design can be conducted aiming at specific bacteria; on the other hand, technological operation is easy and convenient, the process is simple, the reaction condition is gentle, the reactioncan be conducted at the normal temperature, the efficiency is high, the cost is low, repeatability is good, and the subsequent cleaning program is simple; and a product of the metal material with themodified surface has quite high application prospects in the field of the biomedical application

Description

technical field [0001] The invention belongs to the field of medical metal materials, and in particular relates to a method for modifying the surface of metal materials and its products and uses. Background technique [0002] With the improvement of medical level and people's increasing attention to their own health, more and more patients with trauma, spine and osteoarthritis have received operations such as metal internal fixation, orthopedics and artificial joint replacement. Traditional metal implant materials (such as stainless steel, titanium and their alloys) have good biocompatibility, comprehensive mechanical properties and corrosion resistance in biological environments, and have been widely used in clinical practice. However, postoperative infection is characterized by complexity and unpredictability. Even under the premise of strictly implementing surgical asepsis and systemic preventive anti-inflammatory treatment, postoperative infection still occurs from time ...

AI Technical Summary

Problems solved by technology

[0008] ①The clinical application of integral antibacterial metal implant materials is difficult to realize quickly;

[0009] ②Although organic antibacterial agent surface modification materials have made many progresses in the effective sustained release of drugs and the combination of coatings and matrix materials, they have limited antibacterial spectrum, poor high temperature resistance, risk of drug resistance, and poor coating firmness. Difficult to guarantee, difficult to last the effective time of the coating and other defects;

[0010] ③ The preparation process of inorganic antibacterial agent surface modification materials is relatively simple, but as a surface modification material, there are also disadvantages such as easy peeling off of the coating, difficulty in ensuring firmness, and difficulty in lasting the effective time of the coating.

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