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Novel tangerine-pith extract, preparation method thereof and medical application for improving action of intestinal floras

The technology of extract and citrus is applied in the field of novel citrus tangerine complex extract and its preparation method and the medical application field of improving the effect of intestinal flora, which can solve the problems such as the reduction of pectin activity, and achieve the reduction of pH value and the rapid detoxification effect. Significant, relieves constipation worries

Inactive Publication Date: 2018-05-18
杭州络通生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It adopts the method of cutting off the straight chain of pectin to reduce the molecular weight, which will lead to a decrease in the activity of pectin

Method used

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  • Novel tangerine-pith extract, preparation method thereof and medical application for improving action of intestinal floras
  • Novel tangerine-pith extract, preparation method thereof and medical application for improving action of intestinal floras
  • Novel tangerine-pith extract, preparation method thereof and medical application for improving action of intestinal floras

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Such as Figure 8 A method for preparing the citrus complex extract shown, the method comprises the following steps:

[0048] 1) Handling of raw materials

[0049] After crushing, cleaning, and drying, the citrus tangerines enter the acid extraction tank and are heated to 40-50°C. The pH is adjusted to 3.5-4.5 with acid (HCl), and the temperature is kept for 4 hours.

[0050] 2) filter

[0051] The liquid after leaching is filtered to remove the residue, the filtrate is taken into the extraction tank, and the filter residue is subjected to secondary leaching.

[0052] 3) Extraction

[0053] The leached liquid enters the extraction tank, and the extract is added to perform polymer pectin extraction, and the extracted extract enters the squeezing device to obtain polymer pectin.

[0054] 4) Recover the extract

[0055] The extract is recovered through an extraction recovery device, and the remaining part of the extract is the raw material liquid of small molecule pec...

Embodiment 2

[0063] 1.1 Materials

[0064] Obtained in Example 1, the finished product is a brown suspension. After determination, every 100ml contains small molecule pectin ≥ 2000mg, citrus flavonoids (VP) ≥ 400mg, and total solid content ≥ 4500mg.

[0065] 1.2 Animals and Grouping

[0066] 150 clean-grade (level II) Kunming male mice weighing 22-25 g were provided by the Experimental Animal Center of the Academy of Military Medical Sciences. Set up three doses of 0.2, 0.4, 0.8ml / (25g bw) (respectively equivalent to 5, 10, 20 times the recommended dose of the human body) in the experimental group, and set up a constipation model control group and a negative control group, 15 rats in each group animal.

[0067] 1.3 Method

[0068] According to the "Technical Standards for Inspection and Evaluation of Health Food" (2003 Edition), "test method for laxative function", the specific method is as follows:

[0069] 1.3.1 Small intestine motility test

[0070] Each experimental group was ora...

Embodiment 3

[0097] Example 3 Effect of small molecule pectin from citrus tangerine on intestinal mucosal barrier function

[0098] grouping of experimental mice

[0099] AC group is a blank control group, a healthy group;

[0100] AA group is the model control group, a group of patients with dysbacteriosis;

[0101] The TC group is a negative control, and the healthy group eats normally;

[0102] The TA group was a group with dysbacteriosis but was given a normal diet;

[0103] The TP group is a treatment group given to the small molecule pectin (produced by Hangzhou Luotong Biotechnology Co., Ltd.) of the citrus extract of the present invention;

[0104] 1. Indicators of short-chain fatty acids

[0105] Short-chain fatty acids (SCFA) are of great significance to human health. They can affect the transport of colonic epithelial cells, promote the metabolism, growth, and differentiation of colonic cells and small intestinal cells, and provide energy for intestinal mucosal epithelial ce...

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Abstract

The invention relates to the field of medicines, foods and health-care products, and particularly relates to a novel tangerine-pith extract, a preparation method thereof and a medical application forimproving the action of intestinal floras. The novel tangerine-pith extract comprises small-molecular pectin and tangeritin prepared by physically separating extracting liquid after high-molecular pectin is extracted from the tangerine pith; in every 100ml of the extract, the content of the small-molecular pectin is more than or equal to 2000mg, and the content of the tangeritin is more than or equal to 400mg. The invention also discloses application of the small-molecular pectin of the tangerine pith for preparing the medicines, the foods or the health-care products with the functions of moistening the intestine and facilitating feces excretion, regulating the intestinal floras or improving a barrier function of the intestinal mucosa.

Description

technical field [0001] The invention relates to the fields of medicine, food and health care products, in particular to a novel citrus extract, a preparation method thereof and a medical application for improving intestinal flora. Background technique [0002] Citrus pectin is a polysaccharide derived from plant cell walls. It can generally be used as a food additive. It has good gelling, stabilizing, emulsifying, thickening, and suspending functions. Similarly, natural citrus pectin has a large molecular weight (5-300,000 Da ), cannot be absorbed by the intestinal tract after eating and cannot make it fully function in the body. In view of this, modifying the size and structure of its molecules has the prospect of enhancing biological functions. [0003] Several main methods of pectin modification, including chemical (pH) modification, enzyme modification, thermal modification, irradiation modification, graft modification, cross-linking modification and substitution modifi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61K31/715A61P1/10A61P1/00A61P31/04A23L33/105A23L33/125
CPCA23L33/105A23L33/125A23V2002/00A61K31/715A61K31/732A61K36/752A61K2236/33A61K2236/333A61K2236/39A61K2236/53A61K2236/55A23V2200/32A23V2200/30A23V2200/308A23V2200/326A23V2250/21162A23V2250/21A23V2250/2116A23V2250/5072
Inventor 叶兴乾郭长江邓致荣高海峰洪基光于斌
Owner 杭州络通生物科技有限公司
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