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Preparation capable of relieving untoward effect of anaesthetic and preparation method of preparation

A technology of adverse reactions and anesthetics, applied in the field of anesthesia, can solve problems such as difficulty in swallowing, drug resistance, bitterness of traditional Chinese medicine, etc., and achieve the effect of alleviating nausea

Inactive Publication Date: 2018-05-29
AFFILIATED YONGCHUAN HOSPITAL OF CHONGQING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the actual treatment process, abdominal distension usually occurs after abdominal surgery under sevoflurane anesthesia, accompanied by nausea, vomiting and other symptoms. This is a common adverse reaction in abdominal surgery under sevoflurane anesthesia. The conventional treatment method is only Simple postoperative gastrointestinal decompression, fasting or "Neostigmine" injection, or "Exhaust Recipe", the existing literature "Application of Improved Traditional Chinese Medicine Exhaust Recipe in Sevoflurane-anesthetized Patients After Gynecological Abdominal Surgery In "Analysis", aiming at the adverse reactions of sevoflurane anesthesia, the traditional Chinese medicine exhaust formula was improved to speed up the exhaust, but the traditional Chinese medicine tastes bitter, and some patients find it difficult to swallow
One of the most common complications after surgery is infection, which can be resolved with antibiotics, but long-term use of antibiotics can lead to resistance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment one: preparation one of macromolecule filter layer

[0039] Ⅰ Preparation of mixed solution: Dissolve 10 parts by weight of chitin completely in dimethylacetamide solution containing 8wt% lithium chloride, ultrasonically treat for 5 minutes, then add 30ml of maleic acid solution and 30ml of glyoxal solution in sequence , stirred at room temperature for 1 h to obtain a mixed solution;

[0040] II Modified carbon nanotubes: mix 85wt% ethanol water with 20 parts by weight of phthalate, use an ultrasonic disperser with a frequency of 28kHz and a power of 1000W to ultrasonically disperse for 30min, and then add acetic acid to adjust the pH=3.5-4 , and then sequentially add 20 parts by weight of carbon nanotubes, 2 parts by weight of alkyl polyglycosides, and 5 parts by weight of polyethylene glycol, and ultrasonically disperse for 30 minutes to obtain modified carbon nanotubes;

[0041] III Casting solution: Mix 30 parts by weight of polyvinylidene fluoride and 1...

Embodiment 2

[0043] Embodiment two: preparation two of macromolecule filter layer

[0044] Ⅰ Preparation of mixed solution: Dissolve 15 parts by weight of chitin completely in dimethylacetamide solution containing 8 wt% lithium chloride, and after ultrasonic treatment for 8 min, add 40 ml of maleic acid solution and 40 ml of glyoxal solution in sequence , stirred at room temperature for 1.5h to obtain a mixed solution;

[0045] II Modified carbon nanotubes: mix 85wt% ethanol water with 27 parts by weight of phthalate, use an ultrasonic disperser with a frequency of 28kHz and a power of 1000W to ultrasonically disperse for 30min, then add acetic acid to adjust the pH=4-5 , and then sequentially add 40 parts by weight of carbon nanotubes, 3 parts by weight of alkyl polyglycosides, and 6 parts by weight of polyethylene glycol, and ultrasonically disperse for 30 minutes to obtain modified carbon nanotubes;

[0046] III Casting solution: Mix 60 parts by weight of polyvinylidene fluoride and 20...

Embodiment 3

[0048] Embodiment three: preparation three of macromolecule filter layer

[0049] Ⅰ Preparation of mixed solution: Dissolve 20 parts by weight of chitin completely in dimethylacetamide solution containing 8wt% lithium chloride, ultrasonically treat for 10 minutes, then add 50ml of maleic acid solution and 50ml of glyoxal solution in sequence , after adding all of them, stir at room temperature for 2h to obtain a mixed solution;

[0050] II Modified carbon nanotubes: mix 85wt% ethanol water with 30 parts by weight of phthalate, use an ultrasonic disperser with a frequency of 28kHz and a power of 1000W to ultrasonically disperse for 30min, then add acetic acid to adjust the pH=4.5-5.5 , and then sequentially add 50 parts by weight of carbon nanotubes, 5 parts by weight of alkyl polyglycosides, and 8 parts by weight of polyethylene glycol, and ultrasonically disperse for 30 minutes to obtain modified carbon nanotubes;

[0051] III Casting solution: Mix 90 parts by weight of poly...

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Abstract

The invention discloses a preparation cable of relieving an untoward effect of an anaesthetic and a preparation method of the preparation, and relates to the technical field of anaesthetics. The preparation is prepared from the following raw materials in parts by weight: 15 to 30 parts of radix aucklandiae, 10 to 20 parts of bran, 5 to 15 parts of semen arecae, 5 to 10 parts of radix et rhizoma rhei, 5 to 10 parts of herba taraxaci extract, 10 to 20 parts of pericarpium citri reticulatae, 5 to 8 parts of fructus jujubae, 10 to 20 parts of radix scutellariae, 5 to 15 parts of rhizoma pinelliae,5 to 10 parts of radix codonopsis, 5 to 10 parts of radix linderae, 10 to 15 parts of cortex magnoliae officinalis, 10 to 15 parts of fructus aurantii immaturus, 20 to 50 parts of honey, 10 to 20 parts of corn starch, 2 to 10 parts of dextrin and 10 to 15 parts of rock candy, wherein the herba taraxaci extract is a herba taraxaci solution which is obtained by filtering out matters of which the molecular weight is greater than 40,000 by a macromolecular filter layer in a filter column. The preparation disclosed by the invention is capable of relieving the untoward effect generated after the use of the anaesthetic, and is capable of relieving symptoms of nausea, emesis, abdominal distension and the like; the added herba taraxaci extract also has anti-bacterial, anti-inflammation and anti-virus effects; the preparation is basically prepared from traditional Chinese medicines, so that the preparation is capable of effectively helping a patient get well as rapidly as possible.

Description

technical field [0001] The invention relates to the technical field of anesthesia, in particular to a preparation for alleviating adverse reactions of anesthetics and a preparation method thereof. Background technique [0002] The common anesthetic sevoflurane, also known as sevoflurane and heptafluoroisopropylmethyl ether, is a fluorine-containing inhalational anesthetic. The adverse reactions mainly include blood pressure drop, arrhythmia, nausea, and vomiting. In severe cases, it can also cause serious illness. Malignant hyperthermia, shock, anaphylactoid symptoms, rhabdomyolysis, convulsions, hepatic insufficiency, jaundice, and respiratory depression. In the actual treatment process, abdominal distension usually occurs after abdominal surgery under sevoflurane anesthesia, accompanied by nausea, vomiting and other symptoms. This is a common adverse reaction in abdominal surgery under sevoflurane anesthesia. The conventional treatment method is only Simple postoperative ...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61K9/06A61K47/46A61K47/36A61K47/26A61P1/08A61P29/00A61P31/00
CPCA61K9/06A61K36/285A61K36/288A61K36/344A61K36/539A61K36/54A61K36/575A61K36/708A61K36/725A61K36/752A61K36/8888A61K36/889A61K36/899A61K47/26A61K47/36A61K47/46A61K2236/19A61K2236/331A61K2236/333A61K2236/39A61K2236/55A61K2300/00
Inventor 税春玲
Owner AFFILIATED YONGCHUAN HOSPITAL OF CHONGQING MEDICAL UNIV
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