Erythromycin thiocyanate soluble powder and preparation method thereof

A technology of erythromycin thiocyanate and erythromycin thiocyanate containing erythromycin thiocyanate, which is applied in the field of erythromycin thiocyanate soluble powder and its preparation, can solve the problems of poor taste and short half-life, and achieve low cost and batch Great effect of reducing other costs

Inactive Publication Date: 2018-07-27
JIANGXI AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a kind of erythromycin thiocyanate soluble powder, it has added flavoring agent, has adopted slow-release technology to cooperate with each other, solves the problem of bad mouthfeel, half-life period is short, strengthens the antibacterial range of medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) First mix erythromycin thiocyanate 50g, β-cyclodextrin 30g, neotame 5g, sodium saccharin 10g, citric acid 10g, sodium citrate 25g, hydroxypropyl methylcellulose 25g, polyvinylpyrrolidone K30 10g and 835g of water-soluble starch were weighed separately and placed in different containers. spare.

[0022] (2) Take 50ml of polyethylene glycol and 150ml of ethanol and heat to 60°C, add β-cyclodextrin and erythromycin thiocyanate that have been weighed in step 1, stir and dissolve evenly, add the pre-dissolved content in purified water Use 20% sodium citrate solution to bring the pH to 4.0-5.0.

[0023] (3) Take 300ml of purified water and heat it to 80°C, add sodium saccharin, neotame, citric acid, hydroxypropyl methylcellulose, polyvinylpyrrolidone k30, and water-soluble starch weighed in step 1, stir well and dissolve.

[0024] (4) Mix the solutions in step 2 and step 3 evenly, and continue stirring at a stirring speed of 300r / min for 30 minutes. The measured pH valu...

Embodiment 2

[0027] (1) First mix erythromycin thiocyanate 150g, β-cyclodextrin 50g, aspartame 15g, citric acid 15g, sodium bicarbonate 30g, sodium dihydrogen phosphate 10g, hydroxypropyl methylcellulose 25g, 15g of sodium carboxymethylcellulose and 690g of water-soluble starch were weighed respectively and placed in different containers. spare.

[0028] (2) Take 100ml of polypropylene glycol and 150ml of ethanol and heat to 60°C, add β-cyclodextrin and erythromycin thiocyanate that have been weighed in step 1, stir and dissolve evenly, add purified water to pre-dissolve the content to 20% Sodium bicarbonate solution and 20% sodium dihydrogen phosphate solution make the pH reach 4.0-5.0.

[0029] (3) Take 500ml of purified water and heat it to 80°C, add aspartame, citric acid, sodium carboxymethylcellulose, hydroxypropylmethylcellulose, and water-soluble starch weighed in step 1, stir well and dissolve.

[0030] (4) Mix the solutions in step 2 and step 3 evenly, and continue stirring at ...

Embodiment 3

[0033] (1) First add erythromycin thiocyanate 200g, β-cyclodextrin 100g, aspartame 15g, sodium saccharin 5g, citric acid 30g, sodium citrate 30g, sodium dihydrogen phosphate 5g, hydroxypropyl methyl Weigh 25g of cellulose, 50g of polyvinylpyrrolidone k30, 5g of sodium carboxymethylcellulose, and 530g of water-soluble starch, and place them in different containers for later use.

[0034] (2) Take 200ml of polypropylene glycol and 100ml of ethanol and heat to 60°C, add β-cyclodextrin and erythromycin thiocyanate that have been weighed in step 1, stir and dissolve evenly, and add 20% pre-dissolved with purified water Sodium citrate solution and 20% sodium dihydrogen phosphate solution make the pH reach 4.0-5.0.

[0035] (3) Take 500ml of purified water and heat it to 80°C, add aspartame, sodium saccharin, citric acid, sodium carboxymethylcellulose, polyvinylpyrrolidone k30, and hydroxypropylmethylcellulose weighed in step 1 , Stir the water-soluble starch evenly and dissolve it....

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PUM

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Abstract

The invention discloses erythromycin thiocyanate soluble powder and a preparation method thereof. The erythromycin thiocyanate soluble powder is characterized in that each 1000g of the erythromycin thiocyanate soluble powder is prepared from 50 to 200g of erythromycin thiocyanate, 30 to 100g of beta-cyclodextrin, 5 to 20g of corrective, 10 to 30g of acid and alkali regulator, 5 to 50g of slow-release high molecular material, 50 to 200ml of organic solvent, 40 to 500ml of purified water and the balance of water-soluble starch. The erythromycin thiocyanate soluble powder disclosed by the invention has the advantages that (1) a product can be industrially produced in a large batch and the cost is relatively low; the batch is relatively large so that various loss in a production process is reduced and the rate of finished products is effectively improved. Meanwhile, the batch is large so that other cost in a production process is reduced to the greatest extent; (2) the corrective and the slow-release molecular material are introduced into the product and are mutually matched so that the problem that the mouthfeel is not good and the half-life period is short is solved and an antibacterial range of a medicine is enhanced. The medicinal effect of the product can reach or exceed that of a similar product erythromycin thiocyanate soluble powder.

Description

technical field [0001] The invention relates to a preparation method of a veterinary drug preparation, in particular to a erythromycin thiocyanate soluble powder and a preparation method thereof. Background technique [0002] Infections such as pneumonia, sepsis, endometritis, and mastitis caused by Gram-positive pathogens such as Staphylococcus aureus, Streptococcus, and pneumococcus are common diseases in livestock and poultry production; in addition, chronic respiratory tract infections in poultry caused by Mycoplasma Mycoplasma suis pneumonia, white-headed and white-mouthed disease of fry and breeding fish such as green, grass, chain and bighead carp, bacterial gill rot disease of grass carp and herring, white skin disease of silver carp and bighead carp, and streptococcal disease of tilapia, etc. Infection is also an important disease that plagues mass production. If these diseases or infections are not prevented or treated in time, it is easy to cause the death of sic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/7048A61K47/40A61K47/32A61K47/38A61K47/18A61K47/22A61K47/12A61P31/04
CPCA61K9/145A61K9/146A61K31/7048A61P31/04
Inventor 宋德平朱斌唐玉新张帆帆叶昱雷丹袁为锋李指全
Owner JIANGXI AGRICULTURAL UNIVERSITY
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