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Blood lead cleaner for blood lead cleaning in vitro

A technology of blood and blood lead, which is applied in the field of biomedical instruments, can solve problems such as inability to enter red blood cell lead ions, impossibility and poor removal of lead ions, and severe blood lead poisoning, so as to overcome unclear removal principles, relieve illness, compose simple effects

Active Publication Date: 2019-01-11
NANJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, more than 95% of blood lead ions are located in red blood cells and combined with hemoglobin, which causes a major difficulty in blood lead removal
At present, the clinical treatment of blood lead poisoning can be divided into taking lead-dispelling drugs and hemoperfusion; the treatment of mild blood lead poisoning is taking small-molecule lead-dispelling drugs such as edetate disodium calcium, dimercaptopropanol, Mercaptosuccinic acid has a long treatment cycle (40-60 days), large side effects and poor therapeutic effect; the treatment method for severe blood lead poisoning is hemoperfusion, which is to use a hemoperfusion device containing adsorption resin or activated carbon to hemoperfusion. Cleaning, adsorption of toxic substances in serum
Because the size of the adsorbent in the hemoperfusion device is large and fixed inside the perfusion device, it cannot enter the red blood cells to remove the lead ions in the red blood cells. Therefore, hemoperfusion generally removes toxic substances in the serum, and it is almost impossible to remove the lead ions in the red blood cells. Finish

Method used

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  • Blood lead cleaner for blood lead cleaning in vitro

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] 1) Preparation of magnetic ferroferric oxide (Fe 3 o 4 NPs)

[0043] Weigh ferric chloride hexahydrate (1.35g, 5mmol) and fully dissolve it in 30mL of ethylene glycol solution. Sodium acetate (NaAc, 3.6 g) and polyethylene glycol-2000 (PEG-2000 1.0 g) were added with stirring. Stirring was continued for 30 min, and the solution was transferred to a high-temperature reactor at 200°C for 72 h. After natural cooling, it was washed with deionized water and ethanol solution several times, and dried in vacuum at 60 °C.

[0044] 2) Preparation of magnetic Fe3O4 / rich aminated mesoporous silica composites using polylysine as template (MMS / P NPs)

[0045] Dissolve 100 mg sodium lauroyl sarcosinate into 10 mL citric acid / sodium citrate buffer solution (0.1 M, pH 5.2) at room temperature, and add 150 μL ε-polylysine (20 wt%) to the solution. Now the solution immediately becomes an emulsion, generating polylysine / sodium lauroyl sarcosinate composite micelles.

[0046] At room ...

Embodiment 2

[0055] 1) Preparation of magnetic ferric oxide

[0056] Synthesis of ferric oxide nanoparticles (FeO) by hydrothermal method 3 o 4 NPs). The specific method is as follows: Weigh ferric chloride hexahydrate (1.35g, 5mmol) and fully dissolve it in 40mL of ethylene glycol solution. Sodium acetate (NaAc, 1.8 g) and sodium citrate trihydrate (Na 3 Cit 0.2g). Stirring was continued for 1 h, and the solution was transferred to a high-temperature reactor at 200°C for 20 h. After natural cooling, it was washed several times with deionized water and ethanol solution successively, and dried under vacuum at 60°C.

[0057] 2) Preparation of magnetic Fe3O4 / rich aminated mesoporous silica composites (MMS / H NPs) using hyperbranched polyamide (PAMAM) as template

[0058] Will Fe 3 o 4 NPs solution (3mg / mL, 50mL) was mixed with 9mL hydrazine hydrate, and then ultrasonically treated for 30 min. The mixture was transferred to a three-neck flask, and 70 mL of deionized water was added. T...

Embodiment 3

[0064] 1) Preparation of magnetic ferric oxide

[0065] Synthesis of ferric oxide nanoparticles (FeO) by hydrothermal method 3 o 4 NPs). The specific method is as follows: Weigh ferric chloride hexahydrate (1.35g, 5mmol) and fully dissolve it in 40mL of ethylene glycol solution. Sodium acetate (NaAc, 1.8 g) and sodium citrate trihydrate (Na 3 Cit 0.2g). Stirring was continued for 1 h, and the solution was transferred to a high-temperature reactor at 200°C for 20 h. After natural cooling, it was washed several times with deionized water and ethanol solution successively, and dried under vacuum at 60°C.

[0066] 2) Preparation of magnetic Fe3O4 / rich aminated mesoporous silica composites using chitosan as template

[0067] Will Fe 3 o 4 NPs solution (3mg / mL, 50mL) was mixed with 9mL hydrazine hydrate, and then ultrasonically treated for 30 min. The mixture was transferred to a three-neck flask, and 70 mL of deionized water was added. Then 90 mg TEOS was added, and stirr...

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Abstract

The invention discloses a blood lead cleaner for blood lead cleaning in vitro. The blood lead cleaner comprises the following parts: a cardiopulmonary bypass machine, an adsorbent injection device, acontact device and a magnetic separation device which are connected in turn. The adsorbent injection device is loaded with an adsorbent, and the adsorbent is composed of a magnetic ferric tetroxide / rich aminated mesoporous silica composite material with regular mesoporous channels and rich amine organic matter as a template. Compared with oral medicine, the blood lead cleaner of the invention candirectly remove lead ion in blood in a short time through external blood circulation, thereby quickly relieving the condition of blood lead poisoning patient and reducing the side effect caused by taking medicine every day. The blood lead cleaner for blood lead cleaning in vitrohas the advantages that the structure is simple; the use is convenient; the working position can be flexibly changed; theproblem that lead ions in red blood cells cannot be removed by the blood perfusion device is solved; the working efficiency is improved; and the blood lead cleaner for blood lead cleaning in vitro issuitable for widespread popularization and use, and has wide application prospect in the medical field.

Description

technical field [0001] The invention belongs to biomedical instruments, in particular to a blood lead purifying instrument for removing blood lead in vitro. Background technique [0002] Human health is greatly threatened by exposure to lead ions, which can cause severe toxic effects and diseases (such as heart disease and kidney disease, etc.). When lead ions enter the human body, they are mainly deposited in bones, soft tissues and blood. Based on today's biomedical level, it is difficult to remove lead ions deposited in human bones and soft tissues. Therefore, it is of great significance to remove trace amounts of lead ions (blood lead) in blood. However, more than 95% of blood lead ions are located in red blood cells and combined with hemoglobin, which causes a major difficulty in blood lead removal. At present, the clinical treatment of blood lead poisoning can be divided into taking lead-dispelling drugs and hemoperfusion; the treatment of mild blood lead poisoning ...

Claims

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Application Information

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IPC IPC(8): A61M1/36B01J20/10B01J20/28B01J20/30
CPCA61M1/3679B01J20/103B01J20/28009B01J20/3057
Inventor 毛春万密密沈健陈焕王琪初美琳牛倩朱天宇
Owner NANJING NORMAL UNIVERSITY
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