Preparation process of single/multi-element doped sodium titanate nanorod array coating

Abstract

The invention discloses a preparation process of single / multiple-element doped sodium titanate nanorod array coatings. The preparation process is characterized by adopting a hydrothermal (HT) method to prepare different sodium titanate nanorod array coatings on the surface of pure titanium, performing hydrothermal treatment on the coatings again, and achieving single / multiple-element (Mg, Ca, Sr or Zn) doping of nanorod-like sodium titanate in the coatings. The coatings are of double-layer structures and are characterized in that inner layers adjacent to a substrate are dense nanoparticle layers; surface layers are nanorods and are orientated to be nearly perpendicular to the dense nanoparticle layers; no discontinuous interfaces exist between the coatings and the substrate; and the coatings have high bonding strength being 21.0-30.2 N, can be rapidly induced to form bonelike apatite in simulated body fluid environment, and have good biological activity. According to the invention, thepure titanium substrate is subjected to bonelike surface modification from structures and components with reference to human bone; micro-nano structures and trace elements are given to the surfaces of implants; and through synergistic effects of the micro-nano structures and the trace elements, the bone integration effect is improved.

Description

technical field

[0001] The invention belongs to the technical field of bioactivation modification of medical metal surfaces, and relates to a preparation technology of a bioactive coating on the surface of a titanium-based medical implant, in particular to the hydrothermal method of a sodium titanate nanorod array coating co-doped with various elements. Preparation technology. Background technique

[0002] Although titanium and titanium alloys have good biocompatibility, they are still biologically inert materials. It is difficult to integrate with the host bone after implantation, and it is easy to induce fibrous cysts to cause implant loosening and even failure. In order to improve the osseointegration ability of titanium-based implants, the surface of titanium-based implants needs to be modified by bioactivation. It is known that the natural bone matrix is ​​composed of fibrous collagen and nano-particle hydroxyapatite (HA), in which HA is doped with trace metal elements...

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