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Preparation process of single/multi-element doped sodium titanate nanorod array coating

A nanorod array and preparation process technology, which is applied in the field of bioactivation modification of medical metal surfaces, can solve the problems of inaccurate regulation of nanorod configuration parameters, and achieve the effects of high binding strength, simple composition and good biological activity.

Active Publication Date: 2020-08-18
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In previous studies, although sodium titanate nanorods were formed on the surface of titanium by hydrothermal treatment, the configuration parameters of nanorods (such as rod spacing, diameter, orientation) have not been precisely regulated. Single element or multi-element co-doping has not been reported

Method used

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  • Preparation process of single/multi-element doped sodium titanate nanorod array coating
  • Preparation process of single/multi-element doped sodium titanate nanorod array coating
  • Preparation process of single/multi-element doped sodium titanate nanorod array coating

Examples

Experimental program
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Effect test

Embodiment 1

[0034] Put the pure titanium sheet sample in a high-pressure reactor, add NaOH solution with a concentration of 0.3-2M, the filling degree of the solution is 20%, conduct hydrothermal treatment at a temperature of 100°C for 0-1.5 hours, discard the liquid in the reactor, and re- Add NaOH with a concentration of 0.5M, the filling degree of the solution is 20%, and hydrothermally treat at 220°C for 3.5 to 6 hours to obtain the sodium titanate nanorod array coating. The nanorods are nearly perpendicular to the titanium substrate, and their diameter is about 67nm, the pitch is about 72nm, and the length is about 2μm. The surface and cross-section microscopic morphology SEM and nanorod TEM of the coating refer to figure 1 (a), (b) and (c), its scratch test acoustic emission signal and scratch morphology refer to figure 2 , the bonding strength between the coating and the titanium substrate is 20.8±0.1N, and the surface SEM of the sodium titanate nanorod array coating after SBF so...

Embodiment 2

[0037] Put the pure titanium sheet sample in a high-pressure reactor, and add a NaOH solution with a concentration of 1M, the solution filling degree is 20%, hydrothermally treat it at a temperature of 100°C for 1.5 hours, discard the liquid in the reactor, and add a concentration of 0.5 NaOH solution of M, the filling degree of the solution is 20%, and the hydrothermal treatment is carried out at a temperature of 220°C for 3.5 hours to obtain the sodium titanate nanorod array coating (S72). The sodium titanate nanorod array coating (S72) was placed in an autoclave, and Mg(CH 3 COO) 2 Solution, hydrothermally treated at 100°C for 24 hours to obtain a magnesium-doped sodium titanate nanorod array coating, the nanorods are nearly perpendicular to the titanium substrate, the diameter is about 67nm, the spacing is about 72nm, and the length is about 2μm. The morphology of the nanorods did not change substantially before and after doping. Its surface and cross-sectional microscop...

Embodiment 3

[0040] Put the pure titanium sheet sample in a high-pressure reactor, and add a NaOH solution with a concentration of 1M, the solution filling degree is 20%, hydrothermally treat it at a temperature of 100°C for 1.5 hours, discard the liquid in the reactor, and add a concentration of 0.5 NaOH solution of M, the filling degree of the solution is 20%, and the hydrothermal treatment is carried out at a temperature of 220°C for 3.5 hours to obtain the sodium titanate nanorod array coating (S72). The sodium titanate nanorod array coating (S72) was placed in an autoclave, and a concentration of 0.01mM Ca(CH 3 COO) 2 The solution was hydrothermally treated at a temperature of 100°C for 24 hours to obtain a calcium-doped sodium titanate nanorod array coating. The nanorods were nearly perpendicular to the titanium substrate, with a diameter of about 67nm, a spacing of about 72nm, and a length of about 2μm. The morphology of the nanorods did not change substantially before and after do...

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Abstract

The invention discloses a preparation process of single / multiple-element doped sodium titanate nanorod array coatings. The preparation process is characterized by adopting a hydrothermal (HT) method to prepare different sodium titanate nanorod array coatings on the surface of pure titanium, performing hydrothermal treatment on the coatings again, and achieving single / multiple-element (Mg, Ca, Sr or Zn) doping of nanorod-like sodium titanate in the coatings. The coatings are of double-layer structures and are characterized in that inner layers adjacent to a substrate are dense nanoparticle layers; surface layers are nanorods and are orientated to be nearly perpendicular to the dense nanoparticle layers; no discontinuous interfaces exist between the coatings and the substrate; and the coatings have high bonding strength being 21.0-30.2 N, can be rapidly induced to form bonelike apatite in simulated body fluid environment, and have good biological activity. According to the invention, thepure titanium substrate is subjected to bonelike surface modification from structures and components with reference to human bone; micro-nano structures and trace elements are given to the surfaces of implants; and through synergistic effects of the micro-nano structures and the trace elements, the bone integration effect is improved.

Description

technical field [0001] The invention belongs to the technical field of bioactivation modification of medical metal surfaces, and relates to a preparation technology of a bioactive coating on the surface of a titanium-based medical implant, in particular to the hydrothermal method of a sodium titanate nanorod array coating co-doped with various elements. Preparation technology. Background technique [0002] Although titanium and titanium alloys have good biocompatibility, they are still biologically inert materials. It is difficult to integrate with the host bone after implantation, and it is easy to induce fibrous cysts to cause implant loosening and even failure. In order to improve the osseointegration ability of titanium-based implants, the surface of titanium-based implants needs to be modified by bioactivation. It is known that the natural bone matrix is ​​composed of fibrous collagen and nano-particle hydroxyapatite (HA), in which HA is doped with trace metal elements...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/06A61L27/30A61L27/40A61L27/54C23C22/64C23C22/83
CPCA61L27/06A61L27/306A61L27/54A61L2300/102A61L2300/412A61L2300/45A61L2400/12A61L2430/02C23C22/64C23C22/83
Inventor 憨勇余冬梅
Owner XI AN JIAOTONG UNIV
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