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Photothermal drive type shape memory multiscale pore nanocomposite biological scaffold and preparation method thereof

A nano-composite and bio-scaffold technology, applied in medical science, prosthesis, additive processing, etc., can solve the problems of time-consuming materials, slow printing speed, etc., and achieve low production costs, fast stimulus response, and mild preparation process conditions Effect

Active Publication Date: 2019-05-07
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it should be noted that the finer the microstructure constructed by 3D printing technology, that is, the higher the printing accuracy, the slower the printing speed, which makes it very time-consuming to construct a porous scaffold material with a microporous structure by 3D printing technology.
Therefore, it is very necessary to develop 3D printing technology to effectively, conveniently and controllably construct graphene oxide / BSMPs multi-scale porous nanocomposite bioscaffold materials with photothermal actuation shape memory, and there are few reports so far.

Method used

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  • Photothermal drive type shape memory multiscale pore nanocomposite biological scaffold and preparation method thereof
  • Photothermal drive type shape memory multiscale pore nanocomposite biological scaffold and preparation method thereof
  • Photothermal drive type shape memory multiscale pore nanocomposite biological scaffold and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0051] (1) 2 parts by mass of graphene oxide are dispersed in 20 parts by volume of dichloromethane by ultrasonic treatment in an ice-water bath, and then add 20 parts by volume of a dichloromethane solution of low molecular weight carboxy-terminated polylactic acid (PLLA) (containing 2 parts by mass PLLA) mixed. The mixed solution was placed in an ice-water bath and mechanically stirred at 500 r / min for 15 minutes under the protection of nitrogen, then volatilized in a water bath at 30°C to remove dichloromethane, and then placed in a tube furnace under nitrogen atmosphere for calcination at 200°C for 24 hours to obtain hydrophobically modified Graphene oxide.

[0052] (2) Under the action of a 200W ultrasonic machine, 20 minutes of supersonication in an ice-water bath configure 3 parts by volume of dichloromethane suspension (i.e. oil phase), wherein polylactic acid-trimethylcarbonate copolymer (lactic acid, trimethylene carbonate) The molar ratio is 70:30, the molecular we...

Embodiment 2

[0056] (1) 4 parts by mass of graphene oxide are dispersed in 40 parts by volume of dichloromethane by ultrasonic treatment in an ice-water bath, and then add 20 parts by volume of a dichloromethane solution of low molecular weight carboxy-terminated polylactic acid (PLLA) (containing 2 parts by mass PLLA) mixed. The mixed solution was placed in an ice-water bath and mechanically stirred at 500 r / min for 15 minutes under the protection of nitrogen, then volatilized in a water bath at 30°C to remove dichloromethane, and then placed in a tube furnace under nitrogen atmosphere for calcination at 200°C for 24 hours to obtain hydrophobically modified Graphene oxide.

[0057] (2) Under the action of a 200W ultrasonic machine, 20 minutes of ultrasonication in an ice-water bath is used to configure 4 parts by volume of dichloromethane suspension (ie, oil phase), wherein polylactic acid-trimethylcarbonate copolymer (molecular weight is 5 × 10 4 g / mol, wherein the mol ratio of lactic a...

Embodiment 3

[0060] (1) 2 parts by mass of graphene oxide are dispersed in 20 parts by volume of dichloromethane by ultrasonic treatment in an ice-water bath, and then add 20 parts by volume of a dichloromethane solution of low molecular weight carboxy-terminated polylactic acid (PLLA) (containing 2 parts by mass PLLA) mixed. The mixed solution was placed in an ice-water bath and mechanically stirred at 500 r / min for 15 minutes under the protection of nitrogen, then volatilized in a water bath at 30°C to remove dichloromethane, and then placed in a tube furnace under nitrogen atmosphere for calcination at 200°C for 24 hours to obtain hydrophobically modified Graphene oxide.

[0061] (2) Under the action of a 200W ultrasonic machine, ultrasonically set 5 parts by volume of dichloromethane suspension (i.e. oil phase) in an ice-water bath for 20min, in which polylactic acid-trimethylcarbonate copolymer (molecular weight 5.3×10 4 g / mol, wherein the molar ratio of lactic acid and trimethylene ...

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Abstract

The invention belongs to the technical field of intelligent materials, nanocomposite functional materials and biomedical materials and discloses a photothermal drive type shape memory multiscale porenanocomposite biological scaffold and a preparation method thereof. The method comprises the following steps: (1) performing hydrophobic modification on graphene oxide by low molecular weight carboxyl-terminated polylactic acid to obtain hydrophobic modified graphene oxide; (2) adding the hydrophobic modified graphene oxide, a biodegradable shape polymer and a rheological agent to an organic solvent to form an oil phase; adding water to the oil phase, performing mixing and emulsification to obtain a water-in-oil type viscous pickering emulsion; and (3) obtaining a 3D porous emulsion scaffold by extrusion type 3D printing with the water-in-oil type viscous pickering emulsion, and performing drying to obtain the composite biological scaffold. The scaffold consists of multiscale pores and hasthe porosity of 65%-95%; and the scaffold has good shape memory performance under two stimulations of heating and near infrared light irradiation and has good application prospects in the tissue engineering field.

Description

technical field [0001] The invention belongs to the technical field of intelligent materials, nanocomposite functional materials and biomedical materials, and in particular relates to a photothermal-driven shape-memory multi-scale hole nanocomposite biological scaffold and a preparation method thereof. Background technique [0002] Shape memory polymers (SMPs) are a class of smart polymer materials that can deform and fix into a temporary shape under specific external conditions, and return to their original shape after being properly stimulated. SMPs have the characteristics of large deformation, easy forming and processing, strong structural design, adjustable shape responsiveness, light weight and low price, and good corrosion resistance, which makes this type of material widely used in biomedicine, aerospace, smart textiles, automatics, etc. Control and other fields have a good application prospect. Among many SMPs materials, biodegradable shape memory polymers (BSMPs) ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/02A61L27/50A61L27/56A61L27/58B33Y10/00B33Y70/00
Inventor 胡洋李欣杨卓鸿周武艺张乃月胡晨
Owner SOUTH CHINA AGRI UNIV
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